Latest AI and machine learning research in genetics for healthcare professionals.
BACKGROUND/OBJECTIVES: Circadian rhythm disruption is increasingly implicated in tumor progression and therapy resistance. However, its prognostic value and impact on the tumor immune microenvironment in lung adenocarcinoma (LUAD) remain unclear. This study aimed to develop a robust circadian rhythm-based gene signature to improve risk stratification and inform personalized therapeutic strategies ...
DNA-based Boolean logic gates represent a transformative platform in molecular computation, providing a bridge between biological processes. The field has advanced toward sophisticated designs incorporating spatiotemporal control. Distinguished by features such as massive parallelism, biocompatibility, energy efficiency, and programmability, DNA computing enables operations beyond the scope of sil...
Triple-negative breast cancer (TNBC) is a biologically aggressive subtype of breast cancer marked by high heterogeneity and poor prognosis. Copper met...
Gene-by-gene differential expression analysis is a widely used supervised approach for interpreting single-cell RNA-sequencing (scRNA-seq) data. Howev...
Aging is a complex biological process characterized by progressive functional decline, driving the incidence of age-related diseases such as neurodege...
Rice (Oryza sativa) is an important staple food, feeding more than half of the global population. A feasible improvement of rice yield is necessary to...
Crown rust (CR), caused by Puccinia coronata f. sp. avenae, is a major constraint to oat (Avena sativa L.) production in the southern United States. W...
OBJECTIVE: Home healthcare (HHC) clinical notes contain critical infection indicators that clinicians need in structured "indicator + context" pairs. ...
The growing size of genome-wide polymorphism data in animal and plant breeding has raised concerns regarding computational load and time, particularly...
Microglial cells are key players in maintaining brain homeostasis and responding to pathological conditions. Their multifaceted roles in health and di...
The identification of anti-CRISPR proteins (Acrs) is crucial for understanding the regulation of CRISPR-Cas systems and their application in gene edit...
Soft-tissue tumors are rare mesenchymal neoplasms characterized by extensive morphologic and genetic heterogeneity. Advances in molecular pathology ha...
Systemic therapies for advanced hepatocellular carcinoma (HCC) have expanded considerably with the advent of tyrosine kinase inhibitors, immune checkp...
Radiation resistance in bacteria is a critical trait with implications for biotechnology, medicine and environmental science. Deinococcus species poss...
OBJECTIVE: Pancreatic cancer (PC) poses a significant threat to patient quality of life. Ferroptosis, a novel form of non-apoptotic cell death, is imp...
Atherosclerosis (AS) is a chronic inflammatory vascular disorder in which endoplasmic reticulum stress (ERS) plays a crucial regulatory role. However,...
This study presents a novel three-zone fibers-based sequencing batch biofilm reactor designed to achieve simultaneous nitrification, denitrification, ...
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) are associated with poor 5-year survival and substantial treatment-related morbidity. Neoadj...
The growth rate of pigs is a key factor that determines production efficiency and economic benefits. Nevertheless, the regulatory mechanisms underlyin...
BACKGROUND: Zinc finger proteins (ZFPs) play important roles following ischemic stroke (IS), but systematic investigations into their potential as bio...