Latest AI and machine learning research in genetics for healthcare professionals.
Viruses, during their lifecycle, are continuously dependent on host machinery for their survival. Sometimes this dependency leads to uncontrolled cell proliferation in the host, accounting for 12% of virus-associated cancers. Since early times, viruses have been known to produce proteins and dysregulate host proteins, but what is new to the field is the addition of a circular regulatory RNA called...
Our current industrial, agricultural, and medical practices exploit the extraordinary biodiversity generated through billions of years of natural evolution. Despite their high fitness in native habitats, biomolecules and organisms are often not optimally suited for industrial and medical use. Synthetic evolution leverages technologies such as DNA synthesis, CRISPR-Cas engineering, and synthetic bi...
CRISPR-Cas12a (Cpf1) offers distinct advantages for genome editing due to its flexible, T-rich PAM recognition. However, variable cleavage efficiency-...
Tumour organoids have emerged as important tools in brain tumour research, addressing long-standing limitations of conventional two-dimensional cultur...
BACKGROUND: Protein language models (PLMs) have revolutionized protein fitness prediction, yet their application to rapidly evolving viral pathogens i...
Hypoxia is a hallmark of oral squamous cell carcinoma (OSCC) and plays a critical role in driving tumor progression. However, the mechanisms by which ...
Vasoactive intestinal peptide (VIP) plays a multifaceted role in cancer biology, yet its prognostic and immunological implications in melanoma remain ...
Aortic dissection (AD) is a vascular surgical disease that seriously threatens human health. Due to a high misdiagnosis rate and unclear pathogenesis,...
Gene expression programs are widely conserved across grasses despite rapid evolutionary turnover of cis-regulatory element (CRE) sequences, yet the me...
ETHNOPHARMACOLOGICAL RELEVANCE: Taohong Siwu Decoction (TSD), originating from the Qing Dynasty medical text Gynecology Ice Mirror, is a representativ...
Animal pathogenic microorganisms destabilize livestock economies and jeopardize human health through zoonotic transmission and foodborne illness. Trad...
Dysregulated lipid metabolism drives atherosclerosis (AS). Yacon, an Andean lipid-modulating tuber, exerts anti-AS potential, but mechanisms remain un...
Johne's disease (JD) is a chronic wasting disease of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP). For decades, JD manage...
The convergence of artificial intelligence (AI) and microbial biosensor technology is transforming pathogen detection, environmental surveillance, ant...
Pseudomonas aeruginosa is a leading cause of nosocomial infections, particularly in individuals with a compromised immune system. Due to its strong ad...
BACKGROUND AND OBJECTIVE: Neoadjuvant immune-checkpoint inhibitors (ICIs) in muscle-invasive bladder cancer (MIBC) were tested in patient's ineligible...
Microorganisms play significant roles in gastric cancer (GC) progression. However, it is unknown whether circulating microbiome DNA (cmDNA) possesses ...
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by profound clinical and molecular heterogeneity...
BACKGROUND: Mesenchymal stem cells (MSCs) secretome have shown promise in the treatment of alopecia areata (AA). However, the key therapeutic genes re...
BACKGROUND: Despite recent advances, Primary Sclerosing Cholangitis (PSC)-a chronic obstructive biliary disease-still lacks effective therapies to pre...