Latest AI and machine learning research in genetics for healthcare professionals.
The retinoblastoma (RB1) gene is a critical tumor suppressor that regulates cell cycle progression and genomic stability. Although RB1 alterations have been reported in hepatocellular carcinoma (HCC), the biological and clinical consequences of biallelic RB1 inactivation (RB1-Bi) remain poorly defined. We performed a comprehensive allele-specific genomic analysis of HCC patients from the TCGA-LIHC...
NRF2 is a master regulator of redox and metabolic homeostasis that protects normal tissues from stress but is frequently hijacked by cancers to sustain survival and therapy resistance. Although NRF2 is dispensable for normal tissue function, its role in maintaining cancer cells within the native tumor microenvironment has remained undefined. Here, we uncover an essential and previously unrecognize...
Epilepsy comprises a highly heterogeneous group of neurological disorders unified by a persistent predisposition to recurrent seizures, yet driven by ...
AIMS: Early detection and intervention are crucial for effective management of periodontitis. Our study aims to identify diagnostic biomarkers for per...
The Piezo1 channel is a mechanosensitive, non-selective cation channel that converts mechanical forces into electrochemical signals, playing pivotal r...
Based on the principles of engineering reconstruction and programmable design, synthetic biology is driving a paradigm shift in biomedical diagnosis a...
Nowadays, enzyme engineering has moved from traditional structure-based mutagenesis and directed evolution to data-intensive, AI-assisted design parad...
Frontotemporal dementia is commonly caused by loss-of-function mutations in the progranulin gene. Potential therapies for this disorder have entered c...
Antimicrobial resistance (AMR) represents one of the most pressing threats to global public health, undermining the effectiveness of modern antimicrob...
OBJECTIVES: To disentangle the molecular heterogeneity of knee osteoarthritis (OA) through the classification and characterization of transcriptomic c...
To enable rapid and accurate prediction of lignocellulosic pretreatment performance using deep eutectic solvents (DESs), an improved Whale Optimizatio...
Hematopoietic stem cell (HSC) aging underlies age-related immune decline, anemia and increased risk of hematologic malignancies, including clonal hema...
Tau protein aggregates adopt distinct conformations across tauopathies, yet the protein interactions engaged by disease-specific polymorphs remain poo...
Cerebral small vessel disease (CSVD) is a major contributor to stroke and dementia, and it endangers the health of older individuals (>50 years old). ...
SASH1 is a signal adaptor protein involved in cell growth, apoptosis, and immune regulation, and has been increasingly studied in tumor and immune cel...
How do recurrent neural networks (RNNs) internally represent elapsed time to initiate responses after learned delays? To address this question, we tra...
Heavy metal contamination is a major environmental concern due to its persistence, bioaccumulation, and long-term impacts on ecosystems and human heal...
RNA-binding proteins (RBPs) are essential across biology, from viruses to complex multicellular organisms. They regulate gene expression and cellular ...
Antimicrobial resistance poses a growing global health threat, yet large-scale surveillance and risk evaluation remain constrained by the cost and acc...
OBJECTIVES: To compare the ability of different machine learning models to predict the risk of side effects in patients with breast cancer undergoing ...