GERD

Machine Learning Enables Rapid Prediction of Acid-Reducing Agent Drug Interactions: A Streamlined Complement to PBPK Modeling.

pH-dependent drug-drug interactions (DDIs) commonly occur when acid-reducing agents (ARAs) are co-administered with weakly basic drugs. Although physiologically based pharmacokinetic (PBPK) modeling effectively evaluates such DDIs, its use is limited by reliance on costly commercial software. This study developed a PBPK-informed machine learning model to support early assessment of pH-dependent DD...

Contrastive Learning-Powered Ultrafast Genome-Wide Virtual Screening: The Rise of DrugCLIP.

Virtual screening (VS) stands as a cornerstone of early-stage drug discovery, yet long-standing hurdles-including prohibitive computational cost and limited cross-target generalization-have long restricted its genome-wide application, especially with the rapid expansion of AlphaFold-predicted protein structures. Over the past 2 years, contrastive learning has emerged as a genuinely transformative ...

Engineering selective amyloid precursor protein inhibitors by machine learning and deep mutational scanning.

Deep mutational scanning (DMS) has proven effective for mapping protein-protein interactions (PPIs), but it cannot provide complete coverage of the mu...

Building Trustworthy Artificial Intelligence for Gastrointestinal Endoscopy.

Applications of Artificial Intelligence in Cancer Diagnosis and Treatment.

Driven by changes in lifestyle and environmental factors, the global incidence of cancer is steadily increasing, which has established it as a leading...

E3 Ubiquitin Ligase MDM2 Promotes Growth and CD8+ T Cell Dysfunction in Gastric Cancer Through Degradation of SST.

AIM: To figure out the role and molecular mechanism of SST in the progression of GC. METHODS: GC microarray data GSE118916 were downloaded from the GE...

Artificial intelligence tools for the assessment and management of dysphagia: a scoping review.

OBJECTIVES: To explore the existing artificial intelligence (AI) tools used in the assessment and management of dysphagia. DESIGN: Scoping review. DAT...

Toxic effects and mechanisms of methyl 4-hydroxybenzoate in allergic rhinitis: a multi-omics and toxicology study.

PURPOSE: Exogenous chemical exposure is closely associated with allergic rhinitis (AR). Methyl 4-hydroxybenzoate (MeP), a widely used preservative, po...

Explainable artificial intelligence in tricuspid regurgitation: decoding prognosis or encoding measurement?

Benefit of Linked-Color Imaging in Artificial Intelligence-Assisted Diagnosis of Early Gastric Cancer: A Pilot Study With Propensity Score Adjustment.

BACKGROUND AND AIMS: Artificial intelligence (AI)-assisted endoscopy represents a promising approach for lesion detection, yet frequent false-positive...

DINCH induces intestinal toxicity through "ROS-ENO1-PA-lipid peroxidation" axis: An integrated approach combining network toxicology and experimental validation.

Cyclohexane-1,2-dicarboxylic acid diisononyl ester (DINCH), as a "green" alternative to phthalates, has been widely used in consumer products and indu...

Screening of potential targets of (2S)-2'-methoxykurarinone against sepsis and in vivo verification in zebrafish model.

OBJECTIVE: To screen the potential core targets of (2S)-2'-Methoxykurarinone, a dimethyldihydroflavonoid derived from Sophora flavescens, against seps...

Measurement-Informed Deep Learning for Real-Time Monitoring of Hydrodynamic Drying Dynamics in Inkjet-Printed Display Pixels via Low-Resolution Imaging.

Real-time monitoring of drying dynamics is critical for ensuring high-quality thin-film fabrication in inkjet printing. Here, we present a classificat...

Recent progress in clinical and molecular biological research in rectal serrated lesions.

Colorectal cancer ranks among the most common malignancies worldwide. Rectal serrated lesions represent a significant precancerous condition, accounti...

Retinal Pigment Epithelium and Microglia Transplantation in Age-related Macular Degeneration.

Age-related macular degeneration (AMD) remains a leading cause of irreversible blindness worldwide, characterized by the progressive breakdown of the ...

Intelligent recognition and segmentation of anatomical structures in spinal endoscopy: a deep learning approach with 1000 annotated images.

BACKGROUND: Accurate intraoperative identification of anatomical structures is critical for ensuring the safety and efficacy of spinal endoscopic surg...

Integrative Transcriptomic Analysis Identifies a Key Candidate Gene Bridging Inflammation and DNA Repair in Endometriosis.

BACKGROUND: Endometriosis is a chronic, estrogen-dependent inflammatory disorder characterized by the ectopic implantation of endometrial-like tissue....

Mapping the global landscape of robot-assisted hernia surgery research: a bibliometric analysis.

To characterize the worldwide body of literature on robot-assisted hernia surgery through bibliometric and scientometric approaches, and to clarify it...

Generating Patient Documents from Electronic Health Records Using Generative Artificial Intelligence: A Feasibility Study in a Japanese Cancer Center.

OBJECTIVE: Clinical documentation consumes substantial clinician time, potentially detracting from patient care. Generative artificial intelligence (A...

Mitochondria-localized protein-encoding genes and programmed cell death-related genes reveal potential molecular perturbations underlying spontaneous preterm birth.

BACKGROUND: Multiple programmed cell death (PCD) modalities, including apoptosis, autophagy, and ferroptosis, are closely implicated in spontaneous pr...