Geriatrics

Construction and verification of multimodal model for prognosis in elderly patients with aneurysmal subarachnoid hemorrhage.

OBJECTIVE: This study aimed to construct and validate an individualized prediction model for poor prognosis in elderly patients with Aneurysmal subarachnoid hemorrhage (aSAH) based on multimodal indicators such as clinical, imaging, and laboratory data. METHODS: We retrospectively enrolled 241 consecutive patients with aSAH from January 2017 to December 2020 as the training set. An independent tem...

The geographic digital divide among dementia caregivers in the U.S.: a cross-sectional study.

BACKGROUND: Digital health tools, particularly patient portals, can support caregiving, but there is limited understanding of how sociodemographic and geographic factors influence digital health engagement among U.S. caregivers, especially dementia caregivers. Dementia caregiving involves complex coordination, medication management, and frequent healthcare interactions. Therefore, access to online...

Benign-by-design chemistry: Reinventing ligand-based drug design at the edge of AI.

Ligand-based drug design (LBDD) has long driven therapeutic innovation; however, its traditional potency-centered paradigm often oversimplifies biolog...

Disproportionately Elevated Sulcal Index (DESI): An automatically driven index representing disproportionate subarachnoid space enlargement in brain MRI scans.

INTRODUCTION: Idiopathic normal pressure hydrocephalus (iNPH) is frequently underdiagnosed due to non-specific symptoms and the risks of invasive test...

Opportunistic screening for osteoporosis using chest X-rays and deep learning: A systematic review and meta-analysis.

PURPOSE: To evaluate the diagnostic performance of deep learning (DL) algorithms applied to chest radiographs (CXR) for detecting osteoporosis and ass...

Effectiveness of Virtual Reality-Based Simulation Using the Nintendo Wii Balance Board for Assessing the Risk of Falls in Young and Older Adults.

INTRODUCTION: Falls severely affect older adults and are emerging as a global health and financial burden for public health care systems. Multiple stu...

Top five Alzheimer Disease trial eligibility criteria favor men compared to women in a clinic-based cohort.

BACKGROUND: Less women participate in Alzheimer Disease (AD) trials compared to their estimated representation in the global dementia population. OBJE...

Risk classification of oral potentially malignant disorders (OPMDs) using explainable machine learning through a community-based cross-sectional study in rural India.

BACKGROUND: Oral cancer is a major public health problem among the population of India. In rural setting whereby there is exposure to high-risk factor...

Opportunistic CT Fatty Muscle Fraction for Outcome Prediction in Patients Undergoing Transcatheter Mitral Valve Edge-to-Edge Repair.

BACKGROUND: Frailty is a risk factor for adverse outcomes in patients undergoing mitral valve transcatheter edge-to-edge repair (M-TEER) and is interr...

The Last Mile Problem: A Critical Assessment of Physics-Based and AI Tools for Small Molecule Binding Prediction in Virtual Screening.

Docking-based virtual screening (VS) is essential for hit finding in the initial stage of drug or probe discovery. However, it remains prone to high f...

Osteoarthritis and dementia: contrasting disorders driven by mutual pathways of autophagy, mTOR, GLP-1, AMPK, wnt, and WISP1.

INTRODUCTION: Increased global lifespan is paralleled by a rise in non-communicable diseases with osteoarthritis and dementia, including Alzheimer's d...

Incremental diagnostic value of multiregional single-slice CT muscle areas over L3 for sarcopenia: a deep learning-based segmentation study.

OBJECTIVE: To compare the diagnostic performance of multiregional CT-based muscle assessment with conventional single-level (L3) evaluation. MATERIALS...

Evaluation of large language models and retrieval-augmented generation for clinical reasoning in pediatric myopia: a 50-case real-world study.

To evaluate the clinical reasoning ability of large language models (LLMs) and retrieval-augmented generation (RAG) systems in pediatric myopia manage...

Deep learning for automated diagnosis and differentiation of otitis media on temporal bone CT.

BACKGROUND: The accurate diagnosis of otitis media (OM) has long been a challenge for clinicians (especially for less experienced clinicians) due to t...

Integration of glymphatic system function and hippocampal radiomics for diagnosis and conversion prediction of Alzheimer's disease.

BACKGROUND: Glymphatic system (GS) function and hippocampal microstructural changes are promising imaging markers of Alzheimer's disease (AD). This st...

Smartphone-based lightweight AI system for real-time multiple anterior segment disease screening: development and real-world validation.

BACKGROUND: Anterior segment diseases are a major global cause of preventable blindness, especially in regions with limited access to specialized opht...

End-of-surgery prediction of postoperative infectious complications from intraoperative vital-sign dynamics.

Infections after surgery remain a leading cause of morbidity and mortality, yet reliable risk stratification at the end of surgery is limited. Intraop...

TEAMSTER: End-to-end pipeline for generation, processing, and automated quantitative image analysis of 3D tumour spheroids for nanobiology.

Three-dimensional (3D) tumour spheroids are widely used as physiologically relevant in vitro models to study tumour biology, therapeutic responses, an...

Aging in the city: Linking neighborhood features with whole-brain structural and micro-structural changes during aging.

The association between the physical living environment and brain structural changes in older adults remains considerably unexplored despite its poten...

Multi-omics identification of aging-related diagnostic genes and therapeutic targets in renal fibrosis.

BACKGROUND: Renal fibrosis is a pathological hallmark of progressive chronic kidney disease, partly driven by aging-related molecular alterations. How...