Ophthalmology

Glaucoma

Latest AI and machine learning research in glaucoma for healthcare professionals.

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Predicting visual function before glaucoma onset from baseline optical coherence tomography scans using deep learning

Background: The visual field (VF) test results of many eyes with glaucoma progress despite treatment. This suggests that some eyes are either untreated or that the management of intraocular pressure (IOP) does not influence the outcome. In this work, we explore whether future VF parameters can be predicted from a baseline optical coherence retinal nerve fibre layer (OCT-RNFL) scan using a deep lea...

Unseen Insights: An AI-Powered Exploration of Secure Patient Messages in Ophthalmology

Objective To characterize the clinical and administrative concerns communicated through secure ophthalmology messaging and to assess differences in message content across patient sociodemographic groups. Design Cross-sectional study of de-identified, patient-initiated secure messages sent between June 2014 and July 2024. Participants Patients with ophthalmic conditions who initiated secure electro...

Robust Uncertainty Estimation under Distribution Shift via Difference Reconstruction

Estimating uncertainty in deep learning models is critical for reliable decision-making in high-stakes applications such as medical imaging. Prior res...

Jan 27 2026 2601.19341v1
Fair-Eye Net: A Fair, Trustworthy, Multimodal Integrated Glaucoma Full Chain AI System

Glaucoma is a top cause of irreversible blindness globally, making early detection and longitudinal follow-up pivotal to preventing permanent vision l...

Jan 26 2026 2601.18464v1
Population-Scale Analysis of Frequency-Dependent Calcium Dynamics in Retinal Ganglion Cells Under Electric Field Stimulation

Electric field (EF) stimulation is an emerging neuromodulatory strategy for promoting the repair and functional recovery of degenerated neural network...

Camera-Agnostic Autonomous Diagnosis of Glaucomatous Optic Neuropathy using Macular Fundus Imaging and Machine Learning

Abstract Purpose: Glaucoma, a leading cause of irreversible vision loss, often remains undiagnosed due to its asymptomatic progression and the limitat...

Vision-Language Models vs Autonomous AI Agents for Anterior Capsular Radial Folds: A Diagnostic Study

ImportanceVision-language models (VLMs) enable generalist multimodal reasoning, but their ability to resolve brief, low-contrast cues in surgical vide...

F^2TTA: Free-Form Test-Time Adaptation on Cross-Domain Medical Image Classification via Image-Level Disentangled Prompt Tuning

Test-Time Adaptation (TTA) has emerged as a promising solution for adapting a source model to unseen medical sites using unlabeled test data, due to...

Evaluating Large Language Models for Multimodal Simulated Ophthalmic Decision-Making in Diabetic Retinopathy and Glaucoma Screening

Large language models (LLMs) can simulate clinical reasoning based on natural language prompts, but their utility in ophthalmology is largely unexpl...

Early Glaucoma Detection using Deep Learning with Multiple Datasets of Fundus Images

Glaucoma is a leading cause of irreversible blindness, but early detection can significantly improve treatment outcomes. Traditional diagnostic meth...

MedChat: A Multi-Agent Framework for Multimodal Diagnosis with Large Language Models

The integration of deep learning-based glaucoma detection with large language models (LLMs) presents an automated strategy to mitigate ophthalmologi...

Robust Uncertainty-Informed Glaucoma Classification Under Data Shift.

PURPOSE: Standard deep learning (DL) models often suffer significant performance degradation on out-of-distribution (OOD) data, where test data differ...

Jun 2 2025 40455037
Eye-Tracking Algorithm for Early Glaucoma Detection: Analysis of Saccadic Eye Movements in Primary Open-Angle Glaucoma.

Glaucoma remains a leading cause of irreversible blindness worldwide, with early detection crucial for preventing vision loss. This study developed an...

Jun 1 2025 40417430
An Attention Infused Deep Learning System with Grad-CAM Visualization for Early Screening of Glaucoma

This research work reveals the eye opening wisdom of the hybrid labyrinthine deep learning models synergy born out of combining a trailblazing convo...

A deep learning model integrating domain-specific features for enhanced glaucoma diagnosis.

Glaucoma is a group of serious eye diseases that can cause incurable blindness. Despite the critical need for early detection, over 60% of cases remai...

May 23 2025 40410768
RetinaLogos: Fine-Grained Synthesis of High-Resolution Retinal Images Through Captions

The scarcity of high-quality, labelled retinal imaging data, which presents a significant challenge in the development of machine learning models fo...

Accelerated Biological Aging in Exfoliation Glaucoma Assessed by Fundus-Derived Predicted Age and Advanced Glycation End Products.

Glaucoma is an age-related neurodegenerative disease characterized by progressive optic nerve damage. Accelerated biological aging, assessed using pre...

May 15 2025 40429867
Automated Early-Stage Glaucoma Detection Using a Robust Concatenated AI Model.

Glaucoma is a leading cause of irreversible blindness worldwide; therefore, detection of this disease in its early stage is crucial. However, previous...

May 13 2025 40428135
Interpreting Deep Learning Studies in Glaucoma: Unresolved Challenges.

Deep learning algorithms as tools for automated image classification have recently experienced rapid growth in imaging-dependent medical specialties, ...

May 13 2025 34383718
Ethics of Artificial Intelligence in Medicine and Ophthalmology.

BACKGROUND: This review explores the bioethical implementation of artificial intelligence (AI) in medicine and in ophthalmology. AI, which was first i...

May 13 2025 34383720
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