Hematology

Integrative Metabolomic and Lipidomic Signatures of SARS-CoV-2 VOCs: Correlations with Hematological and Biochemical Markers.

In the present study, we investigated biochemical, hematological, lipidomic, and metabolomic alterations associated with different SAR-CoV-2 variants of concern (VOCs), such as WT, α, β, γ, and δ, as well as their impact on COVID-19 severity. Across the first and second waves in India, a machine learning approach was used in 3134 COVID-19 patients, and nine critical biochemical and hematological p...

Fidaxomicin Reduces Collagen Expression in Intestinal Fibroblasts Via Platelet-Derived Growth Factor Receptor Beta and Glycogen Synthase Kinase-3 Beta Inhibition.

INTRODUCTION: About 30%-50% of patients with Crohn's disease (CD) eventually develop intestinal strictures, with intestinal fibrosis being a major component of them. There is currently no approved medication to treat fibrotic strictures.

Investigation of the Significance of Blood Signatures on Sepsis-Induced Acute Lung Injury in Sepsis Within 24 Hours.

Sepsis is an infection-induced dysregulated cellular response that leads to multiorgan dysfunction. As a time-sensitive condition, sepsis requires pr...

Predicting the risk of postoperative gastrointestinal bleeding in patients with Type A aortic dissection based on an interpretable machine learning model.

BACKGROUND: Gastrointestinal bleeding (GIB) is a common complication following Type A aortic dissection (TAAD) surgery, significantly impacting progno...

Development and validation of a multiple myeloma diagnostic model based on systemic lupus erythematosus-associated genes and identification of specific genes.

BACKGROUND: Monoclonal immunoglobulins are commonly found in multiple myeloma (MM), a prevalent hematologic malignancy that is currently incurable. In...

Infrared and Raman spectroscopy of blood plasma for rapid endometrial cancer detection.

BACKGROUND: Endometrial cancer (EC) is the 6th most common cancer among women worldwide. No effective non-invasive screening methods or approved blood...

Advancements in Hematologic Malignancy Detection: A Comprehensive Survey of Methodologies and Emerging Trends.

The investigation and diagnosis of hematologic malignancy using blood cell image analysis are major and emerging subjects that lie at the intersection...

Artificial Intelligence and Data Science Methods for Automatic Detection of White Blood Cells in Images.

Data scieQuerynce (DS) methods and artificial intelligence (AI) are critical in today's healthcare services operations. This study focuses on evaluati...

AI-Driven Automated Blood Cell Anomaly Detection: Enhancing Diagnostics and Telehealth in Hematology.

Hematology plays a critical role in diagnosing and managing a wide range of blood-related disorders. The manual interpretation of blood smear images, ...

The future of critical care: AI-powered mortality prediction for acute variceal gastrointestinal bleeding and acute non-variceal gastrointestinal bleeding patients.

BACKGROUND: Acute upper gastrointestinal bleeding (AUGIB) is one of the most common critical diseases encountered in the intensive care unit (ICU), wi...

Stromal vascular fraction in canine osteoarthritis: advantages, applications, and insights for veterinary practitioners.

Canine osteoarthritis (OA) stands as a prevalent and excruciating joint condition that represents a promising application of stromal vascular fraction...

Development and evaluation of a direct disk diffusion, rapid antimicrobial susceptibility testing method from blood culture positive for Gram-negative bacilli using rapid molecular testing and microbiology laboratory automation.

Rapid antimicrobial susceptibility testing (RAST) using disk diffusion (DD) from positive blood cultures (BC) can aid initiation of effective antimicr...

Direct evaluation of antiplatelet therapy in coronary artery disease by comprehensive image-based profiling of circulating platelets.

Coronary artery disease (CAD) is a leading cause of death globally. Antiplatelet therapy remains crucial in preventing and treating CAD-associated thr...

A novel model for predicting immunotherapy response and prognosis in NSCLC patients.

BACKGROUND: How to screen beneficiary populations has always been a clinical challenge in the treatment of non-small-cell lung cancer (NSCLC) with imm...

SFTSV induces liver ferroptosis through m6A-related ferritinophagy.

Severe fever with thrombocytopenia syndrome (SFTS) is a widely prevalent infectious disease caused by severe fever with thrombocytopenia syndrome viru...

Identification of nanoparticle infiltration in human breast milk: Chemical profiles and trajectory pathways.

Breast milk is crucial for infant health, offering essential nutrients and immune protection. However, despite increasing exposure risks from nanopart...

Impact of body mass index on D-dimer diagnostic utility for deep vein thrombosis in patients with cancer: a single-center retrospective analysis.

BACKGROUND: Deep vein thrombosis (DVT) is a common complication in cancer patients associated with significant morbidity and mortality. D-dimer is a w...

Jumping on the moon as a potential exercise countermeasure.

The Moon's gravitational field strength (17% Earth's gravity) may facilitate the use of bodyweight jumping as an exercise countermeasure against muscu...

From Multi-Omics to Visualization and Beyond: Bridging Micro and Macro Insights in CAR-T Cell Therapy.

Chimeric antigen receptor T (CAR-T) cell therapies, a cornerstone of immunotherapy, have demonstrated remarkable efficacy in treating hematological ma...

Sex-specific associations between exposure to metal mixtures and mitochondrial DNA copy number: A repeated-measures study.

Few repeated-measures studies with multiple time points have evaluated the sex-specific association between mitochondrial DNA copy number (mtDNAcn) an...