Hematology

Hemophilia

Latest AI and machine learning research in hemophilia for healthcare professionals.

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Factors Influencing the Binding of HIV-1 Protease Inhibitors: Insights from Machine Learning Models.

HIV-1 protease inhibitors are crucial for antiviral therapies targeting acquired immunodeficiency sy...

May 2025 40432489
Gasdermin D drives the systemic storm and mortality after trauma with hemorrhage to a greater degree in biological females than males.

Severe injury accompanied by hemorrhagic shock triggers an early release of cell constituents into t...

May 2025 40435214
Drug repurposing to identify potential FDA-approved drugs targeting three main angiogenesis receptors through a deep learning framework.

Tumor cell survival depends on the presence of oxygen and nutrients provided by existing blood vesse...

May 2025 40418485
CDKN1A and EGR1 are key genes for endoplasmic reticulum stress-induced ferroptosis in MASH.

Metabolic dysfunction-associated steatohepatitis (MASH) is a complex liver disease whose pathogenesi...

May 2025 40414463
Oral ENPP1 inhibitor designed using generative AI as next generation STING modulator for solid tumors.

Despite the STING-type-I interferon pathway playing a key role in effective anti-tumor immunity, the...

May 2025 40410143
Investigating the Mechanisms of Pazopanib-induced Hepatotoxicity: Insights from Network Toxicology, Microarray Analysis, and Machine Learning.

BACKGROUND: Pazopanib is an oral multi-kinase inhibitor that is effective in treating various tumors...

(1)
May 2025 40417760
HR-SC-an academic-developed machine learning framework to classify HRD-positive ovarian cancer patients and predict sensitivity to olaparib.

BACKGROUND: High-grade serous ovarian cancer (OC) patients with defects in the homologous recombinat...

(2)
May 2025 40393377
Investigation of the Significance of Blood Signatures on Sepsis-Induced Acute Lung Injury in Sepsis Within 24 Hours.

Sepsis is an infection-induced dysregulated cellular response that leads to multiorgan dysfunction....

(1)
May 2025 40421173
SFTSV induces liver ferroptosis through m6A-related ferritinophagy.

Severe fever with thrombocytopenia syndrome (SFTS) is a widely prevalent infectious disease caused b...

May 2025 40340535
Dual-Mode Detection of Trypsin and Screening of Trypsin Inhibitors on the Basis of a Colorimetric/Fluorescence Sensing Probe.

Trypsin is a specific and reliable diagnostic biomarker of pancreatic function and pathological chan...

May 2025 40351095
Efficacy and Safety of rVIII-SingleChain in Surgical Prophylaxis.

INTRODUCTION: RVIII-SingleChain is a B-domain-truncated factor VIII construct with a covalent bond b...

May 2025 40347118
HIV-1 suppression and rare dolutegravir resistance in antiretroviral-experienced people with HIV in Liberia.

BACKGROUND: Increasingly, persons with HIV in Liberia are receiving antiretroviral therapy containin...

May 2025 40346187
Study on the effect and mechanism of PM on the expression of alzheimer's-like lesions related proteins in SH-SY5Y cells.

Fine particulate matter (PM) is recognized as one of the most harmful environmental pollutants to hu...

May 2025 40348349
Biocatalytic production of a monoamine oxidase B/catechol-O-methyltransferase inhibitor from piperine by engineered P450 BM3.

The single-step biotransformation of the natural compound piperine into a known dual inhibitor of mo...

May 2025 40339650
Comprehensive analysis of Syzygium cumini L. pomace extract as an α-amylase inhibitor: In vitro inhibition, kinetics, and computational studies.

Type 2 diabetes mellitus (T2DM) is a widespread metabolic disorder characterized by impaired regulat...

(3)
May 2025 40339502
A cascade nanoreactor based on metal azolate framework integrated natural enzyme for α-glucosidase activity assay and inhibitor screening.

Enzyme cascades have attracted widespread attention owing to the exceptional specificity and efficie...

May 2025 40344727
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