Hematology

Hemophilia

Latest AI and machine learning research in hemophilia for healthcare professionals.

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History Dependence in a Chemical Reaction Network Enables Dynamic Switching.

This work describes an enzymatic autocatalytic network capable of dynamic switching under out-of-equ...

Mar 2022 35257479
TIMP-1: A Circulating Biomarker for Pulmonary Hypertension Diagnosis Among Chronic Obstructive Pulmonary Disease Patients.

Pulmonary hypertension (PH) is a common complication of chronic obstructive pulmonary disease (COPD)...

Feb 2022 35284430
A novel graph convolutional neural network for predicting interaction sites on protein kinase inhibitors in phosphorylation.

Protein kinase-inhibitor interactions are key to the phosphorylation of proteins involved in cell pr...

Jan 2022 34997142
Artificial intelligence-based identification of octenidine as a Bcl-xL inhibitor.

Apoptosis plays an essential role in maintaining cellular homeostasis and preventing cancer progress...

Dec 2021 34953212
Elevated Levels of Urinary Biomarkers TIMP-2 and IGFBP-7 Predict Acute Kidney Injury in Neonates after Congenital Heart Surgery.

 This article investigated the utility of urine biomarkers tissue inhibitor of metalloproteinase-2 ...

Dec 2021 35734207
Machine Learning-Based HIV Risk Estimation Using Incidence Rate Ratios.

HIV/AIDS is an ongoing global pandemic, with an estimated 39 million infected worldwide. Early detec...

Dec 2021 36304038
A computer-aided drug design approach to discover tumour suppressor p53 protein activators for colorectal cancer therapy.

Colorectal cancer (CRC) is the third most detected cancer and the second foremost cause of cancer de...

Nov 2021 34861473
Discovery of Pyrazolo[3,4-]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation.

Alterations of discoidin domain receptor1 (DDR1) may lead to increased production of inflammatory cy...

Nov 2021 34821145
SUBA-Itraconazole for Primary Antifungal Prophylaxis After Allogeneic Hematopoietic Cell Transplantation.

BACKGROUND: Itraconazole (ITZ) is an effective agent when used as primary invasive fungal disease (I...

Nov 2021 35559121
Detecting immunotherapy-sensitive subtype in gastric cancer using histologic image-based deep learning.

Immune checkpoint inhibitor (ICI) therapy is widely used but effective only in a subset of gastric c...

Nov 2021 34811485
Deep learning-driven scaffold hopping in the discovery of Akt kinase inhibitors.

Scaffold hopping has been widely used in drug discovery and is a topic of high interest. Here a deep...

Oct 2021 34560776
Stem-cell based, machine learning approach for optimizing natural killer cell-based personalized immunotherapy for high-grade ovarian cancer.

Advanced high-grade serous ovarian cancer continues to be a therapeutic challenge for those affected...

Oct 2021 34582617
Kinase Inhibitor Scaffold Hopping with Deep Learning Approaches.

The protein kinase family contains many promising drug targets. Many kinase inhibitors target the AT...

Sep 2021 34586824
Domain Adaptation-Based Deep Learning for Automated Tumor Cell (TC) Scoring and Survival Analysis on PD-L1 Stained Tissue Images.

We report the ability of two deep learning-based decision systems to stratify non-small cell lung ca...

Aug 2021 34003747
CYPlebrity: Machine learning models for the prediction of inhibitors of cytochrome P450 enzymes.

The vast majority of approved drugs are metabolized by the five major cytochrome P450 (CYP) isozymes...

Aug 2021 34488021
Artificial Inteligence-Based Decision for the Prediction of Cardioembolism in Patients with Chagas Disease and Ischemic Stroke.

BACKGROUND: Chagas disease (CD) and ischemic stroke (IS) have a close, but poorly understood, associ...

Aug 2021 34399284
Interpretable deep recommender system model for prediction of kinase inhibitor efficacy across cancer cell lines.

Computational models for drug sensitivity prediction have the potential to significantly improve per...

Aug 2021 34362938
Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy.

For an emerging disease like COVID-19, systems immunology tools may quickly identify and quantitativ...

Aug 2021 34350827
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