Hemophilia

FOXK1 induced upregulation of KIF20A promotes hepatocellular carcinoma progression via Wnt/β-Catenin/EMT signaling.

Liver cancer ranks sixth in incidence and third in mortality worldwide, with hepatocellular carcinoma (HCC) accounting for 90% of cases. Kinesin family genes (KIFs) have been implicated in HCC progression, but their specific roles remain unclear. Here, using multiple transcriptomic datasets and machine learning, we systematically screened KIF genes in HCC and identified nine key differentially exp...

In silico discovery and biological evaluation of a novel selective HDAC8 inhibitor featuring 1H-pyrazolo[3,4-b]pyridine scaffold.

Histone deacetylase 8 (HDAC8), a pivotal epigenetic regulator orchestrating chromatin remodeling and transcriptional control, has emerged as a compelling anticancer target owing to its frequent dysregulation in malignancies. The development of isoform-selective inhibitors, however, confronts substantial challenges because of the pronounced structural conservation across HDAC isoforms. This study d...

Optimization and External Validation of a Deep Learning Model for Segmentation and Quantification of Traumatic Brain Injury Lesions on Head Computed Tomography.

Current methods for radiological classification in traumatic brain injury (TBI), such as the Marshall and Rotterdam score, provide an incomplete descr...

Stacked ensemble learning and in-silico profiling reveal dual DPP-IV and SGLT2 inhibitors from Moringa oleifera metabolites.

Diabetes mellitus (DM) is a growing global health challenge, particularly in low-resource settings where access to effective therapies remains limited...

The 487-gene expression profile test guides systemic therapy selection to improve outcomes for patients with atopic dermatitis: Results from a prospective trial.

BACKGROUND: Current atopic dermatitis (AD) therapy selection does not account for molecular drivers of disease, contributing to inadequate disease con...

Discovery of a novel compound against BmNPV using virtual screening based on the protein structure of the viral whole genome.

Currently, effective antiviral drugs against Bombyx mori nucleopolyhedrovirus (BmNPV) are still lacking, which has caused significant economic damage ...

Automating classification of treatment responses to combined targeted therapy and immunotherapy in HCC.

Tyrosine kinase inhibitor (TKI) combined with immunotherapy regimens are now widely used for treating advanced hepatocellular carcinoma (HCC), but the...

Machine Learning and Computer Simulation Disentangle the Fuzzy Inhibitor Binding by Hsp90.

Heat shock protein 90 (Hsp90) is a key cancer drug target, yet the highly flexible N-terminal ATP-binding pocket yields seemingly conflicting crystall...

Predicting vesicoureteral reflux outcomes using artificial intelligence: A critical appraisal using APPRAISE-AI.

Vesicoureteral reflux (VUR) is a common congenital urinary tract anomaly in children, associated with recurrent urinary tract infections (UTIs) and lo...

Biochar for next-generation anaerobic digestion: Global trends, multi-mechanism enhancement, and AI-driven prospects.

Biochar-enhanced anaerobic digestion is widely recognized as a promising strategy for converting organic waste into renewable energy. This article pre...

Screening for novel chemical scaffolds targeting PCNA identifies the Hsp90alpha inhibitor SNX-2112.

Proliferating cell nuclear antigen (PCNA) protein is an emerging therapeutic target for several diseases including cancers, and certain viral infectio...

Interpretable machine learning rationalizes carbonic anhydrase inhibition via conformal and counterfactual prediction.

Human carbonic anhydrase (hCA) isoforms IX and XII are promising anticancer targets. Yet, their selective inhibition remains elusive due to close simi...

A systems approach identifies MERTK as a therapeutic vulnerability in ZFTA-RELA-driven ependymomas.

Ependymomas (EPN) are rare central nervous system tumors that account for approximately 10% of intracranial tumors in children and 4% in adults. Despi...

Advances in the postoperative care of the liver transplant recipient.

PURPOSE OF REVIEW: Survival rates following liver transplantation now exceed 90% at one year. However, the patient group undergoing liver transplantat...

Xanthine oxidase inhibitors for gout: Applications and novel drug development.

Hyperuricemia is a well-established direct trigger of gouty arthritis. Xanthine oxidase (XO), the rate-limiting enzyme in uric acid production, repres...

Synergistic impact of Gram-negative bacterial co-infection on invasive pulmonary aspergillosis in non-neutropenic patients: a machine learning-based risk stratification approach.

BACKGROUND: Invasive pulmonary aspergillosis (IPA) is increasingly recognized in non-neutropenic patients, where coexisting bacterial infections, part...

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1-Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation.

Hypertrophic scars (HS) are fibroproliferative lesions arising from aberrant wound healing, their high incidence is countered by a lack of effective i...

AlphaMissense pathogenicity scores predict response to immunotherapy and enhances the predictive capability of tumor mutation burden.

Tumor Mutational Burden (TMB) is a widely used biomarker for selecting cancer patients for immune checkpoint inhibitor (ICI) therapy. However, TMB alo...

Evaluation of an Artificial Intelligence Conversational Chatbot to Enhance HIV Preexposure Prophylaxis Uptake: Development and Usability Internal Testing.

BACKGROUND: The HIV epidemic in the United States disproportionately impacts gay, bisexual, and other men who have sex with men (MSM). Despite the eff...

Treating autism with Bumetanide: Identification of responders using Q-Finder machine learning algorithm.

Bumetanide, a specific NKCC1 co-transporter inhibitor, restores deficient GABAergic inhibition implicated in various brain disorders, including Autism...