Hemophilia

Artificial intelligence enabled interpretation of ECG images to predict hematopoietic cell transplantation toxicity.

Artificial intelligence (AI)-enabled interpretation of electrocardiogram (ECG) images (AI-ECGs) can ...

Machine learning and radiomics for predicting efficacy of programmed cell death protein 1 inhibitor for small cell lung cancer: A multicenter cohort study.

An ensemble machine learning model generates a focused screening library for the identification of CDK8 inhibitors.

The identification of an effective inhibitor is an important starting step in drug development. Unfo...

Predicting gastric cancer tumor mutational burden from histopathological images using multimodal deep learning.

Tumor mutational burden (TMB) is a significant predictive biomarker for selecting patients that may ...

Clinical Validation of Artificial Intelligence-Powered PD-L1 Tumor Proportion Score Interpretation for Immune Checkpoint Inhibitor Response Prediction in Non-Small Cell Lung Cancer.

PURPOSE: Evaluation of PD-L1 tumor proportion score (TPS) by pathologists has been very impactful bu...

AI serves up target and inhibitor for lung fibrosis.

Identification and Characterization of Immune Checkpoint Inhibitor-Induced Toxicities From Electronic Health Records Using Natural Language Processing.

PURPOSE: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, yet their use is ...

Elevated tissue factor pathway inhibitor is associated with intracerebral haemorrhage of unknown cause in young adults.

CLINICAL RATIONALE FOR STUDY: We have reported that intracerebral haemorrhage (ICH) of unknown cause...

Predicting Immune Checkpoint Inhibitor-Related Pneumonitis via Computed Tomography and Whole-Lung Analysis Deep Learning.

BACKGROUND: Immune checkpoint inhibitor-related pneumonitis (ICI-P) is a fatal adverse event of immu...

Inhibition of choline kinase as an antiamoebic approach in Entamoeba histolytica infection.

Entamoeba histolytica is the parasite responsible for amoebiasis, which can result in amoebic coliti...

[Advancements in virtual screening techniques for study of enzyme inhibitor compounds].

Enzymes are closely associated with the onset and progression of numerous diseases, making enzymes a...

Extended Venous Thromboembolism Prophylaxis after Robotic Staging for Endometrial Cancer.

OBJECTIVES: Our objectives were to estimate the incidence of venous thromboembolism (VTE) after robo...

Mesoscopic structural analysis via deep learning processing, with a special reference to in vitro alteration in collagen fibre induced by a gap junction inhibitor.

Dense connective tissue, including the ligament, tendon, fascia and cornea, is formed by regularly a...

SPLDExtraTrees: robust machine learning approach for predicting kinase inhibitor resistance.

Drug resistance is a major threat to the global health and a significant concern throughout the clin...

Low Risk of Venous Thromboembolism After Robot-assisted Radical Prostatectomy Through Systemic Image Assessment: A Prospective Study.

BACKGROUND/AIM: The aim of the study was to evaluate the risk of venous thromboembolism (VTE) after ...

[Bridge between Total Synthesis of Bioactive Natural Products and Development of Drug Leads].

Although natural products are rich sources for drug discovery, only a small percentage of natural pr...

Study on the differentially expressed genes and signaling pathways in dermatomyositis using integrated bioinformatics method.

Dermatomyositis is a common connective tissue disease. The occurrence and development of dermatomyos...

Successful Resuscitation of a Young Girl Who Drank Rivastigmine With Respiratory Failure.

Rivastigmine is a non-competitive reversible inhibitor of acetylcholinesterase which is approved as ...

Anticoagulant treatment in elderly patients with atrial fibrillation: a position paper.

Atrial fibrillation (AF) is common in the elderly. The treatment of this condition is based on antic...

[Endogenous nocciceptin/orphanin FQ affect ischemic arrhythmias in rats through Raf kinase inhibitor protein].

OBJECTIVE: To investigate whether endogenous nociceptin/orphanin FQ (N/OFQ) can inhibit arrhythmia a...

Machine learning-based predictors for immune checkpoint inhibitor therapy of non-small-cell lung cancer.