Hemophilia

Development of an electronic health record-based Human Immunodeficiency Virus (HIV) risk prediction model for women, incorporating social determinants of health.

BACKGROUND: Human Immunodeficiency Virus (HIV) pre-exposure prophylaxis (PrEP) prevents HIV transmission but has low uptake among women. Identifying women who could benefit from PrEP remains a challenge. This study developed a women-specific model to predict HIV risk within a year using electronic health record (EHR) data and social determinants of health (SDoH).

Data-driven assessment of corrosion in reinforced concrete structures embedded in clay dominated soils.

The integration of Artificial Intelligence techniques, particularly Artificial Neural Networks (ANNs), has transformed predictive modeling in structural and durability engineering. This study investigates the use of ANN-based approaches to predict the corrosion rates of mild steel reinforcement embedded in cementitious composites subjected to clay-dominated soil environments. Key environmental par...

Comprehensive machine learning analysis of PANoptosis signatures in multiple myeloma identifies prognostic and immunotherapy biomarkers.

PANoptosis is closely associated with tumorigenesis and therapeutic response, yet its role in multiple myeloma (MM) remains unclear. This study analyz...

Artificial intelligence-driven label-free detection of chronic myeloid leukemia cells using ghost cytometry.

Early diagnosis and treatment initiation of chronic myeloid leukemia (CML) are considered to increase the rate of deep molecular response. However, th...

Predictive value of machine learning for radiation pneumonitis and checkpoint inhibitor pneumonitis in lung cancer patients: a systematic review and meta-analysis.

Some studies have developed machine learning (ML) models for the prediction of pneumonitis following immunotherapy and radiotherapy for patients with ...

Deep learning-based dipeptidyl peptidase IV inhibitor screening, experimental validation, and GaMD/LiGaMD analysis.

BACKGROUND: Dipeptidyl peptidase-4 (DPP4) is considered a crucial enzyme in type 2 diabetes (T2D) treatment, targeted by inhibitors due to its role in...

Boosting Checkpoint Blockade Immunotherapy with T Cell Membrane Redox Homeostasis Regulation and Deep Learning Enhanced NIR-II Imaging.

Immune checkpoint blockade therapy has revolutionized clinical oncotherapy by intercepting immunosuppressive pathways in tumor tissues. Nevertheless, ...

Discovery of SARS-CoV-2 papain-like protease inhibitors through machine learning and molecular simulation approaches.

The papain-like protease (PLpro), a cysteine protease found in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), plays a crucial role in v...

HEalth Record Optimization for Identifying Candidates for HIV PRe-Exposure Prophylaxis: A Community-Informed Approach to Model Development.

Electronic health record (EHR)-based models to identify individuals who may benefit from pre-exposure prophylaxis (PrEP) outperform traditional risk s...

Predicting Affinity Through Homology (PATH): Interpretable binding affinity prediction with persistent homology.

Accurate binding affinity prediction (BAP) is crucial to structure-based drug design. We present [Formula: see text], a novel, generalizable machine l...

Profiling antigen-binding affinity of B cell repertoires in tumors by deep learning predicts immune-checkpoint inhibitor treatment outcomes.

The capability to profile the landscape of antigen-binding affinities of a vast number of antibodies (B cell receptors, BCRs) will provide a powerful ...

In silico & in vitro approaches suggest osteoclastogenesis induction underlying fractures in Entrectinib-treated children.

Entrectinib, a potent, CNS-active, TRK and ROS1 inhibitor is associated with occurrence of bone fractures, particularly in pediatric patients. We emba...

Machine learning prediction of intestinal α-glucosidase inhibitors using a diverse set of ligands: a drug repurposing effort with drugBank database screening.

UNLABELLED: The global rise in diabetes mellitus (DM) poses a significant health challenge, necessitating effective therapeutic interventions. α-Gluco...

Artificial Intelligence in Hemophilia Management: Revolutionizing Patient Care and Future Directions.

Recent advancements in artificial intelligence (AI) hold significant promise for transforming hemophilia care. This review explores AI's impact on cri...

Utilizing Machine Learning to Improve Neutralization Potency of an HIV-1 Antibody Targeting the gp41 N-Heptad Repeat.

The N-heptad repeat (NHR) of the HIV-1 gp41 prehairpin intermediate (PHI) is an attractive potential vaccine target with high sequence conservation ac...

Functional connectivity alterations of the pregenual anterior cingulate cortex by ketamine and the modulation by lamotrigine.

BACKGROUND: Neuroimaging studies have linked the beneficial effects of subanaesthetic ketamine doses in psychiatric conditions characterized by chroni...

Self-Driving and Detachable Lab-Microrobots Tailor Drug Delivery for Closed-Loop Stimulation of the Antitumor Immune Cycle.

Hypoxia arises in most solid tumors with insufficient blood flow, which hinders the delivery and efficacy of therapeutic agents to tumors. In this wor...

Atomic Ga Site Enables Photonanozymes with Specific Inhibition Modes for Primary Drug Screening.

Enzyme inhibition plays a crucial role in drug discovery by governing interactions between molecules and distinct enzymatic sites, facilitating the id...

Formative evaluation of the acceptance of HIV prevention Artificial Intelligence chatbots by Black gay, bisexual, and other men who have sex with men in the Southern United States: Focus group study.

Gay, bisexual, and other men who have sex with men (MSM) account for 60% of new HIV infections among Black Americans in the Southern United States (U....

Neddylation status determines the therapeutic sensitivity of tyrosine kinase inhibitors in chronic myeloid leukemia.

BCR::ABL1-targeting tyrosine kinase inhibitors (TKIs) dominate the treatment of chronic myeloid leukemia (CML) over the past decades. In this study, w...