Hematology

Hemophilia

Latest AI and machine learning research in hemophilia for healthcare professionals.

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Showing 484-504 of 4,162 articles
Identification of predictive subphenotypes for clinical outcomes using real world data and machine learning.

Predicting treatment response is an important problem in real-world applications, where the heteroge...

May 2025 40355420
Blood-brain barrier crossing biopolymer targeting c-Myc and anti-PD-1 activate primary brain lymphoma immunity: Artificial intelligence analysis.

Primary Central Nervous System Lymphoma is an aggressive central nervous system neoplasm with poor r...

May 2025 40088978
Clinical characteristics, outcomes, and predictive modeling of patients diagnosed with immune checkpoint inhibitor therapy-related pneumonitis.

PURPOSE: The aim of this study is to better characterize the clinical characteristics and outcomes o...

May 2025 40343491
Discovery of hematopoietic progenitor kinase 1 inhibitors using machine learning-based screening and free energy perturbation.

Hematopoietic progenitor kinase 1 (HPK1) is a key negative regulator of T-cell receptor (TCR) signal...

May 2025 38198294
Molecular Determinants of Orthosteric-allosteric Dual Inhibition of PfHT1 by Computational Assessment

To overcome antimalarial drug resistance, carbohydrate derivatives as selective PfHT1 inhibitor ha...

Predicting Targeted Therapy Resistance in Non-Small Cell Lung Cancer Using Multimodal Machine Learning

Lung cancer is the primary cause of cancer death globally, with non-small cell lung cancer (NSCLC)...

ProtoBERT-LoRA: Parameter-Efficient Prototypical Finetuning for Immunotherapy Study Identification

Identifying immune checkpoint inhibitor (ICI) studies in genomic repositories like Gene Expression...

Machine Learning-Based Discovery of a Novel Noncovalent MurA Inhibitor as an Antibacterial Agent.

The bacterial cell wall is crucial for maintaining the integrity of bacterial cells. UDP-N-acetylglu...

Mar 2025 40077992
COX-2 Inhibitor Prediction With KNIME: A Codeless Automated Machine Learning-Based Virtual Screening Workflow.

Cyclooxygenase-2 (COX-2) is an enzyme that plays a crucial role in inflammation by converting arachi...

Jan 2025 39797538
Transcriptomic profiling and machine learning uncover gene signatures of psoriasis endotypes and disease severity

Despite increased understanding of psoriasis pathogenesis, molecular classification of clinical phen...

Structure-based Generation of a Secondary Nucleation Inhibitor in α-Synuclein Aggregation Using a Conditional Diffusion Model

The process of α-synuclein aggregation results in the formation of amyloid fibrils, which accumulate...

Transcriptional Signatures of Field Cancerization in Gastric Cancer

The high rate of local recurrence in gastric adenocarcinoma (GA) suggests that carcinogenesis is not...

In Silico Design of APOE ɛ4 Interaction Inhibitor Peptides for Alzheimer’s Disease

Protein-protein interactions (PPIs) are essential for cellular functions, and their aberrant formati...

Discovery of RdRp Thumb-1 as a novel broad-spectrum antiviral family of targets and MDL-001 as a potent broad-spectrum inhibitor thereof

Multiple positive-sense, single-stranded RNA (+ssRNA) viruses cause human diseases, ranging from mil...

Single-cell lineage trajectory defines CDK inhibitor-sensitive cells-of-origin in esophageal squamous cell cancer

Understanding the cells of origin is essential for overcoming therapy resistance in esophageal squam...

A General Transformer-Based Multi-Task Learning Framework for Predicting Interaction Types between Enzyme and Small Molecule

Predicting enzyme–small molecule interactions is critical for drug discovery and generally understan...

AlphaMissense pathogenicity scores predict response to immunotherapy and enhances the predictive capability of tumor mutation burden

Tumor Mutational Burden (TMB) is a widely used biomarker for selecting cancer patients for immune ch...

Design of Allosteric Inhibitors for Mutant EGFR by Combined use of Machine Learning and Molecular Dynamics Simulations

The non-small cell lung cancer (NSCLC)-associated Epidermal Growth Factor Receptor (EGFR) mutant L85...

A Machine Learning–3D Microvessel Platform Identifies Kinase Targets Restoring Blood-Brain-Barrier Endothelial Integrity

Disruption of the brain endothelial barrier is a hallmark of traumatic brain injury (TBI), and contr...

Subtype-Specific Dependencies and Drug Vulnerabilities Enable Precision Therapeutics in Head and Neck Cancer

Molecular heterogeneity in head and neck squamous cell carcinoma (HNSCC) is well recognized, yet exi...

Electronic Health Record-Based Prediction Models to Inform Decisions about HIV Pre-exposure Prophylaxis: A Systematic Review

Several clinical prediction models have been developed using electronic health records data to help ...

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