Hemophilia

Discovery and development of small-molecule inhibitors targeting cytotoxic T lymphocyte associated protein 4 to enhance cancer immunotherapy and reduce side effects.

The immune system plays crucial role to fight against cancer. Still, cancer cells have evolved mecha...

AI-driven discovery and validation of a GIPC1 PDZ domain inhibitor for pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) remains highly aggressive, with a five-year survival rate un...

Mechanisms, management and prevention of anorectal sexually transmitted infections.

Anorectal bacterial sexually transmitted infections, predominantly chlamydia, gonorrhoea and syphili...

Machine learning-powered qualitative structure properties relationship models for prediction of corrosion inhibition efficiencies of triazoles.

The development of a holistic theoretical framework that can predict the corrosion inhibition effici...

Machine learning approaches to predict early cardiac immune-related adverse events in patients receiving immune checkpoint inhibitors.

PURPOSE: Immune checkpoint inhibitor (ICI)-induced cardiac immune-related adverse events (cardiac ir...

Artificial intelligence in immune checkpoint inhibitor research: A bibliometric analysis of the landscape.

This bibliometric analysis examines the transformative role of artificial intelligence (AI) in immun...

Targeted radionuclide-drug conjugates: Current status and perspectives.

Radionuclide drug conjugates (RDCs) are emerging molecular platforms for diagnostic imaging, targete...

Novel biomarkers for the differential diagnosis of paediatric MYH9-related diseases and immune thrombocytopenia revealed by plasma proteomics.

Differentiating myosin heavy chain 9 (MYH9)-related disease (MYH9-RD) from immune thrombocytopenia (...

DINCH Exposure Contributes to Osteoarthritis Pathogenesis via TSPO-Mediated Chondrotoxicity: Evidence from In Silico Prediction to Experimental Validation.

Diisononyl cyclohexane-1,2-dicarboxylate (DINCH), a widely used plasticizer substitute, has been wid...

Retinal Pigment Epithelium and Microglia Transplantation in Age-related Macular Degeneration.

Age-related macular degeneration (AMD) remains a leading cause of irreversible blindness worldwide, ...

Verbenol acts as a low-entropy pan-inhibitor of quorum sensing to attenuate Pseudomonas aeruginosa virulence and resolve pulmonary inflammation.

The rise of multidrug-resistant Pseudomonas aeruginosa necessitates urgent anti-virulence strategies...

SOHO State of the Art Updates and Next Questions | Predictive Markers for Ruxolitinib in Myelofibrosis.

Myelofibrosis (MF) is a biologically heterogeneous myeloproliferative neoplasm characterized by cons...

Global genomic surveillance of β-lactam resistance in Escherichia coli across human, animal, and environmental reservoirs.

BACKGROUND: Escherichia coli poses a global health threat from increasing β-lactam resistance. This ...

Integrated spatially guided transcriptomics and multiplex imaging identify a high-risk CD163+/CD11c-subgroup in diffuse large B-cell lymphoma.

Emerging data identify infiltrating immune cells in diffuse large B‑cell lymphoma (DLBCL) as prognos...

Can artificial intelligence lead the next frontier of hemophilia management and care?

Real-World Evidence-Based Study on Treatment-Free Remission in Chronic Myeloid Leukemia.

BACKGROUND: Treatment-free remission (TFR) has become a treatment goal for chronic myeloid leukemia ...

Mapping Non-Homologous Pocket Compatibilities to Identify Hidden Drug-Target Relationships: A Pocket Hopping Framework.

Predicting small molecule-protein interactions across nonhomologous proteins remains challenging bec...

Recent developments in the therapeutic management of acid-related gastrointestinal diseases.

INTRODUCTION: Acid-related gastrointestinal diseases, particularly gastroesophageal reflux disease (...

Activation of sigma non-opioid intracellular receptor 1 (S1R) receptor inhibits plexin domain containing 2 (Plxdc2) driven microglial inflammation to ameliorate depressive-like behaviours in mice.

BACKGROUND AND PURPOSE: Microglia are central regulators of neuroinflammation in depression. Drivers...

Disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis after failure of biologic or targeted synthetic therapy: a systematic review and network meta-analysis.

RATIONALE: After inadequate response to first-line biologic or targeted synthetic (b/ts) disease-mod...

A machine learning-driven multitask framework for antibiotic resistance prediction in Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae bloodstream infections among hematological malignancy patients.

BACKGROUND: Inappropriate empirical antimicrobial therapy (IEAT) significantly increases mortality i...