Latest AI and machine learning research in hepatitis for healthcare professionals.
BACKGROUND: Emerging zoonotic poxviruses such as lumpy skin disease virus (LSDV) and monkeypox pose significant threats to animal and human health, yet validated antiviral targets remain scarce. Variola virus, the causative agent of smallpox, also belongs to the Poxviridae family, emphasizing the importance of preparedness against potential re-emergence. METHODS: We developed an AI-Enabled structu...
The rapid growth of RNA therapeutics and artificial intelligence (AI) has transformed antiviral drug discovery and created an urgent need for interdisciplinary training that links computational methods with authentic virology research. Despite this, undergraduate and postgraduate curricula rarely provide students with opportunities to contribute directly to an active AI-driven drug design research...
BACKGROUND: Parkinson's disease (PD) still lacks therapies that can simultaneously improve symptoms and slow neurodegenerative progression, making the...
BACKGROUND: Robust forecasting of hepatitis B trends is important for long-term surveillance and public health planning in China. However, evidence re...
Metabolic reprogramming is a core hallmark of cancer, yet how it contributes to the clinical heterogeneity of lung adenocarcinoma (LUAD) remains poorl...
Single-stranded RNA viruses co-assemble their capsid with the genome, and variations in capsid structures can have significant functional relevance. I...
Coxsackievirus B3 is a primary cause of viral myocarditis, with ≈20% of cases progressing to dilated cardiomyopathy. Despite its clinical significance...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), enters host cells via intera...
BACKGROUND: Electronic consultations (e-consults) improve specialist access but burden providers. We developed LiVersa, a customized large language mo...
Invasive candidiasis represents a critical global health challenge, causing approximately 6.5 million bloodstream infections annually with mortality r...
Chronic liver disease (CLD) affects millions worldwide, yet accurately staging its progression without liver biopsy remains a major clinical challenge...
Accurately detecting patterns of interest across a large number of images presents a significant challenge in data analysis for high-throughput analyt...
Modeling and predicting viral mutations before they emerge plays a crucial role in pandemic preparedness, enabling the early identification of emergin...
Autoimmune Hepatitis (AIH) is a liver disease with a wide clinical spectrum, driven by an abnormal immune response against the liver parenchyma. Chall...
ETHNOPHARMACOLOGICAL RELEVANCE: Hypericum perforatum L. has been used for centuries in traditional medicine, with core therapeutic applications includ...
Liver transplant (LT) is a life-saving treatment for patients with cirrhosis and/or hepatocellular carcinoma (HCC), but organ shortages and suboptimal...
Conventional immune checkpoint inhibitors (ICIs) remain largely ineffective in microsatellite-stable metastatic colorectal cancer (MSS mCRC), where lo...
INTRODUCTION: Highly attenuated poxviruses serve as potent viral vectors, oncolytic agents, and therapeutic vaccines. They can accommodate and stably ...
Direct photodisappearance rate constant (kd) is a key parameter determining the persistence of chemical pollutants in surface waters. High-throughput ...