Infectious Disease

Hepatitis

Latest AI and machine learning research in hepatitis for healthcare professionals.

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Artificial Intelligence Evaluation of Stool Quality Guides Management of Hepatic Encephalopathy Using a Smartphone App.

Lactulose-based hepatic encephalopathy treatment requires bowel movements/day titration, which is improved with Bristol stool scale (BSS) incorporation. Dieta app evaluates artificial intelligence (AI)-based BSS (AI-BSS) with stool images. Initially, controls (N = 13) and cirrhosis patients on lactulose/not on lactulose (n = 33) were trained on the app. They entered self-reported BSS (self-BSS) wi...

Dec 28 2023 38153339

Direct Detection of 4-Dimensions of SARS-CoV-2: Infection (vRNA), Infectivity (Antigen), Binding Antibody, and Functional Neutralizing Antibody in Saliva.

We developed a 4-parameter clinical assay using Electric Field Induced Release and Measurement (EFIRM) technology to simultaneously assess SARS-CoV-2 RNA (vRNA), nucleocapsid antigen, host binding (BAb) and neutralizing antibody (NAb) levels from a drop of saliva with performance that equals or surpasses current EUA-approved tests. The vRNA and antigen assays achieved lower limit of detection (LOD...

Dec 28 2023 38234820
Regulatory effects of mangiferin on LPS-induced inflammatory responses and intestinal flora imbalance during sepsis.

Studies suggest that mangiferin (MAF) has good therapeutic effects on chronic bronchitis and hepatitis. Also, it is one of the antiviral ingredients i...

Dec 27 2023 38455195
Mpox (formerly monkeypox): pathogenesis, prevention, and treatment.

In 2022, a global outbreak of Mpox (formerly monkeypox) occurred in various countries across Europe and America and rapidly spread to more than 100 co...

Dec 27 2023 38148355
Anti-Dengue: A Machine Learning-Assisted Prediction of Small Molecule Antivirals against Dengue Virus and Implications in Drug Repurposing.

Dengue outbreaks persist in global tropical regions, lacking approved antivirals, necessitating critical therapeutic development against the virus. In...

Dec 27 2023 38257744
potently inhibits the activity of SARS-CoV-2 3CL protease.

The ongoing coronavirus infectious disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) still urgently r...

Dec 26 2023 38371528
CryoVirusDB: A Labeled Cryo-EM Image Dataset for AI-Driven Virus Particle Picking.

With the advancements in instrumentation, image processing algorithms, and computational capabilities, single-particle electron cryo-microscopy (cryo-...

Dec 26 2023 38234823
Identification of oral therapeutics using an AI platform against the virus responsible for COVID-19, SARS-CoV-2.

This study introduces a sophisticated computational pipeline, , designed for the discovery of antiviral drugs based on their interactions within the ...

Dec 22 2023 38186640
Integrated Bioinformatics and Validation Reveal and Its Related Molecules as Potential Identifying Genes in Liver Cirrhosis.

Liver cirrhosis remains a significant global public health concern, with liver transplantation standing as the foremost effective treatment currently ...

Dec 21 2023 38275754
Humoral Immune Responses after an Omicron-Adapted Booster BNT162b2 Vaccination in Patients with Lymphoid Malignancies.

To accommodate waning COVID-19 vaccine immunity to emerging SARS-CoV-2 variants, variant-adapted mRNA vaccines have been introduced. Here, we examine ...

Dec 20 2023 38275946
Epidemiological and viral studies of rabies in Bali, Indonesia.

BACKGROUND AND AIM: Rabies has been endemic in Bali since 2009, and cases has recently increased. Unfortunately, there is a lack of available vaccines...

Dec 20 2023 38328353
Exploring the joint potential of inflammation, immunity, and receptor-based biomarkers for evaluating ME/CFS progression.

BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition with no identified diagnostic biomarkers t...

Dec 20 2023 38187396
Machine learning and experimental screening of chromatin regulator signatures and potential drugs in hepatitis B related hepatocellular carcinoma.

Many evidences have confirmed that chromatin regulator factors (CRs) are involved in the progression of cancer, but its potential mechanism of affecti...

Dec 18 2023 38111163
Drug Repositioning Based on Deep Sparse Autoencoder and Drug-Disease Similarity.

Drug repositioning is critical to drug development. Previous drug repositioning methods mainly constructed drug-disease heterogeneous networks to extr...

Dec 16 2023 38103130
EFFICIENT ESTIMATION OF THE MAXIMAL ASSOCIATION BETWEEN MULTIPLE PREDICTORS AND A SURVIVAL OUTCOME.

This paper develops a new approach to post-selection inference for screening high-dimensional predictors of survival outcomes. Post-selection inferenc...

Dec 14 2023 38405375
Bloody Lips - Gluing Bleeding Lower Lip Spider Angioma in Decompensated Cirrhosis.

Spider angiomas are dilated vascular channels in the skin. They have a central arteriole with surrounding vascular channels resembling legs of a spide...

Dec 9 2023 38261889
Optimizing Signal Management in a Vaccine Adverse Event Reporting System: A Proof-of-Concept with COVID-19 Vaccines Using Signs, Symptoms, and Natural Language Processing.

INTRODUCTION: The Vaccine Adverse Event Reporting System (VAERS) has already been challenged by an extreme increase in the number of individual case s...

Dec 7 2023 38062261
Effects of Transcranial Direct Current Stimulation on Cognitive Deficits in Depression: A Systematic Review.

BACKGROUND: Major depressive disorder is the leading cause of mental health-related burden globally and up to one-third of major depressive disorder p...

Dec 1 2023 38765850
Development of a sensitive direct competitive chemiluminescent enzyme immunoassay for gentamicin based on the construction of a specific single-chain variable fragment-alkaline phosphatase fusion protein.

A sensitive chemiluminescent enzyme immunoassay (CLEIA) was established for the determination of gentamicin (GEN) residue levels in animal tissue. Thi...

Nov 30 2023 38283367
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