Latest AI and machine learning research in hepatitis for healthcare professionals.
Recent advances in 2D image generation have achieved remarkable quality,largely driven by the capacity of diffusion models and the availability of large-scale datasets. However, direct 3D generation is still constrained by the scarcity and lower fidelity of 3D datasets. In this paper, we introduce Zero-1-to-G, a novel approach that addresses this problem by enabling direct single-view generation...
Since ancient hepatitis B virus (HBV) sequencing data are scarce and incomplete, the evolutionary dynamics of HBV have long remained enigmatic. This data gap hinders a comprehensive understanding of HBV genetic variations, evolutionary trajectories, and host interactions in different historical periods, preventing insight into its long-standing co-evolutionary relationship with humans. In this stu...
Given that influenza vaccine effectiveness depends on a good antigenic match between the vaccine and circulating viruses, it is important to assess th...
Despite improved outcomes with atezolizumab plus bevacizumab (A+B) in hepatocellular carcinoma (HCC), primary refractoriness (PRef), characterised by ...
Since the emergence of SARS-CoV-2, numerous studies have investigated antibody interactions with viral variants in vitro, and several datasets have be...
Phospholipidosis is a cellular condition characterized by the excessive accumulation of phospholipids within cells, that also can be induced by medica...
The recognition of B epitopes by B cells of the immune system initiates an immune response that leads to the production of antibodies to combat bacter...
The development of personalized cancer vaccines relies heavily on accurately identifying neoepitopes capable of eliciting strong immune responses. T c...
Seasonal influenza remains a significant public health challenge through unpredictable antigenic drift, where accumulated mutations enable immune evas...
Identifying effective neoantigen sequences is essential for enhancing anti-tumor immunity. However, the vast sequence space (>109 possible peptides) a...
Accurate detection of tumors is critical for the success of oncologic surgical intervention. Along with any modality for the localization of tumors, s...
Cellular function is driven by the activity proteins in stable complexes. Protein complex assembly depends on the direct physical association of compo...
The ability to engineer enzymes for desired reactions is a cornerstone of modern biotechnology, yet identifying suitable starting proteins remains a c...
Metabolic dysfunction–associated steatotic liver disease (MASLD) often coexists with chronic hepatitis B (CHB), yet early diagnosis remains challengin...
Self-assembling protein nanoparticles are being increasingly utilized in the design of next-generation vaccines due to their ability to induce antibod...
Viral infections pose significant global health challenges, underscoring the urgent need for improved medications. Nevertheless, traditional medicinal...
Hepatitis B virus (HBV) infection causes approximately one million deaths annually and remains a major driver of hepatocellular carcinoma. Despite its...
Persistent emergence of viral variants capable of evading host immunity constitutes a significant threat to public health. This antigenic evolution fr...
Enveloped viruses must enter host cells to initiate infections through a fusion process, during which the fusion proteins undergo significant and comp...
T-cells play a key role in adaptive immunity by mounting specific responses against diverse pathogens. An effective binding between T-cell receptors (...