Latest AI and machine learning research in hepatitis for healthcare professionals.
There have been several attempts to develop machine learning (ML) models to identify human infecting viruses from their genomic sequences, with varying degrees of success. Direct comparison between models is problematic, because these models are typically trained and evaluated on different datasets having different baseline, outcome, and features. In this paper we present a standardized dataset of...
T-cell immunogenicity, the ability of peptide fragments to elicit T-cell responses, is a critical determinant of the safety and efficacy of protein therapeutics and vaccines. While deep learning shows promise for in silico prediction, the scarcity of comprehensive immunogenicity data is a major challenge. We present T-SCAPE, a novel multi-domain deep learning framework that leverages adversarial d...
Herpes simplex viruses (HSV-1 and HSV-2) are widespread human pathogens, most commonly causing oral and genital lesions. These DNA viruses use recombi...
The striatal direct and indirect pathways constitute the core for basal ganglia function in action control. Although both striatal D1- and D2-spiny pr...
Identifying promising therapeutic targets from thousands of genes in transcriptomic studies remains a major bottleneck in biomedical research. While l...
Extracellular vesicles (EVs) are lipid-delineated nanoparticles that are produced by most cell types. EVs contain complex molecular cargoes that can h...
Analysis and interpretation of omics data largely benefit from the use of prior knowledge. However, this knowledge is fragmented across resources and ...
Multiple positive-sense, single-stranded RNA (+ssRNA) viruses cause human diseases, ranging from mild colds to deadly pandemics. These viruses share a...
Epstein–Barr virus (EBV) is strongly implicated in Multiple Sclerosis (MS), but how its influence varies across MS clinical types remains unclear. We ...
Antibodies play a central role in neutralizing pathogens through direct interference with viral entry and recruitment of effector immune cells. Howeve...
Understanding RNA structures is essential for exploring its diverse cellular roles. Chemical modification-based RNA structure probing remains a key ap...
Single-cell RNA sequencing has transformed our understanding of cellular diversity, yet current singlecell foundation models (scFMs) remain limited in...
Neglected Tropical Diseases (NTDs) continue to be a global health concern, affecting millions worldwide. Arboviruses such as Chikungunya virus (CHIKV)...
DNA:protein interactions involving large structural deformations of DNA underpin essential biological processes. Although correlative evidence suggest...
Understanding the spatiotemporal dynamics of T-cell clones is a critical challenge in immunology and immunotherapy, with direct implications for cance...
Seasonal influenza viruses undergo continuous antigenic drift due to mutations in the hemagglutinin (HA) protein, rendering vaccines ineffective and p...
A target-specific bait dispenser is required for oral bait vaccination of the endangered Tasmanian devil (Sarcophilus harrisii) against the deadly dev...
Preclinical models are used extensively to study diseases and potential therapeutic treatments. Complex in vitro platforms incorporating human cellula...
Messenger ribonucleic acid (mRNA) vaccines represent a major advancement in synthetic biology, yet their efficacy remains limited by how efficiently t...
Signal peptides are short amino acid sequences attached to the N-termini of mature proteins. They play determinant roles in protein expression as well...