Infectious Disease

Hepatitis

Latest AI and machine learning research in hepatitis for healthcare professionals.

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irAE-GPT: Leveraging large language models to identify immune-related adverse events in electronic health records and clinical trial datasets

Large language models (LLMs) have emerged as transformative technologies, revolutionizing natural language understanding and generation across various domains, including medicine. In this study, we investigated the capabilities, limitations, and generalizability of Generative Pre-trained Transformer (GPT) models in analyzing unstructured patient notes from large healthcare datasets to identify imm...

Mining Social Media Data for Influenza Vaccine Effectiveness Using a Large Language Model and Chain-of-Thought Prompting

Influenza vaccine effectiveness (VE) estimation plays a critical role in public health decision-making by quantifying the real-world impact of vaccination campaigns and guiding policy adjustments. Current approaches to VE estimation are constrained by limited population representation, selection bias, and delayed reporting. To address some of these gaps, we propose leveraging large language models...

A simple feed forward neural network to predict the 2025 outbreak of measles in the USA

Measles is a highly contagious viral disease associated with a variety of severe complications. Since 1963, widespread usage of a highly effective vac...

AI portal tract detection and characterisation for a regional analysis of steatosis and inflammation in MASLD, MASH, and AIH

Annotation of liver biopsies, for disease staging is increasingly aided by digital pathology, however existing systems do not quantify inflammation an...

Mapping Inequities in Global Vaccine Sentiment Research

Negative public sentiment towards vaccination (PSV) poses significant challenges to the effectiveness of immunization programs, with dramatic effects ...

Diagnostic accuracy of a high-throughput multiplex immunoassay for the detection of Mpox virus infection and MVA-BN vaccination up to two years after exposure

Mpox, caused by mpox virus (MPXV), has gained global attention following the 2022 Clade IIb outbreak and the emergence of two novel Clade I lineages i...

Evaluation of the Bangkok Health Research and Ethics Interest Group: reflecting on the experiences of group members, researchers and facilitators participating in an urban community advisory board in Thailand

The Mahidol Oxford Tropical Medicine Research Unit (MORU), headquartered in Bangkok, conducts research on tropical medicine and global health. MORU wo...

Assessment and Prediction of Clinical Outcomes for ICU-Admitted Patients Diagnosed with Hepatitis: Integrating Sociodemographic and Comorbidity Data

Hepatitis, a disease characterized by inflammation of the liver, is a leading global health challenge that contributes to over 1.3 million deaths annu...

Omics Integration Uncovers Mechanisms Associated with HIV Viral Load and Potential Therapeutic Insights

While antiretroviral therapy (ART) has significantly improved disease prognosis in people with HIV (PWH), understanding the biological mechanisms unde...

Direct causal variable discovery leveraging the invariance principle: application in biomedical studies

Accurate identification of direct causal (parental) variables for a target is of primary interest in many applications, especially in biomedical scien...

Automating Handwritten Vaccination Record Transcription with Generative Multimodal AI Models: A Proof of Concept Study from The Gambia

Handwritten home-based vaccination records (HBRs) are a vital source of immunization data, yet manual transcription in household surveys is time-consu...

Predicting Short-Term Mortality in Severe Cirrhosis: An Interpretable Machine Learning Model Integrating Routine Clinical Indicators

The critical need for precise risk stratification in severe liver cirrhosis is underscored by its substantial 30-day mortality rates, demanding reliab...

Comparative Analysis of Long COVID and Post-Vaccination Syndrome: A Cross-Sectional Study of Clinical Symptoms and Machine Learning-Based Differentiation

Long COVID is a well-documented post-viral syndrome, while post-vaccination syndrome (PVS) remains poorly characterized. Understanding their similarit...

Human breast cancer is linked to Epstein-Barr virus because it targets stem cells: bioinformatic chromosome correlations

Breast cancer originates from rare “cancer stem cells”. Stem cells are especially susceptible to becoming cancerous because they readily become differ...

Machine Learning-Based Reconstruction of 2D MRI for Quantitative Morphometry in Epilepsy

Structural neuroimaging analyses require ‘research quality’ images, acquired with costly MRI acquisitions. Isotropic (3D-T1) images are desirable for ...

Spatial Distribution and Associated Factors Influencing 2024 Measles-Rubella Vaccination Campaign Coverage among Children Aged 9–59 Months in Mainland Tanzania

Globally, measles remains a major cause of child mortality, and rubella is the leading cause of birth defects among all infectious diseases. In Mainla...

Integration of Gene Expression and Digital Histology to Predict Treatment-Specific Responses in Breast Cancer

Deep learning models applied to digital histology can predict gene expression signatures (GES) and offer a low-cost, rapidly available alternative to ...

From Sequences to Strategies: Early Detection of New SARS-CoV-2 Variants via Genetic Distance to Reduce Hospitalizations

The COVID-19 pandemic highlighted the critical need for robust methods to monitor viral evolution and detect emerging variants of concern (VOCs). Trad...

Candidate Correlates of Protection in the HVTN505 HIV-1 Vaccine Efficacy Trial Identified by Positive-Unlabeled Learning

With a goal of unveiling mechanisms by which vaccines can provide protection against HIV-1 acquisition, several studies have explored correlates of ri...

Machine Learning-Driven Identification of Serotype-Independent Pneumococcal Vaccine Candidates using samples from Human Infection Challenge Studies

Identifying conserved, immunogenic proteins that confer protection against Streptococcus pneumoniae colonisation could enable development of serotype-...

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