HIV/AIDS

Stage-specific ROMO1 in rheumatoid arthritis: predictive immune insights into the MIF pathway and HLA-DR/IL2RA axis via integrated GWAS, transcriptomic, single-cell, and spatial profiling.

Emerging evidence links reactive oxygen species modulator 1 (ROMO1), a key mitochondrial ROS regulator, to rheumatoid arthritis (RA) pathogenesis. However, its exact mechanism remains elusive given the conflicting evidence about its specific function. We used a four-level integrative framework combining multi-omics data and literature‑supported mechanistic inference. At the genetic level, Mendelia...

From Biomedical Datasets to Fairness-Aware Recommendations: An Integrated Data Orchestration Pipeline for Binary Clinical Predictions.

Many problems in biomedicine can be posed as binary classification. When they are addressed using artificial intelligence methods, though, average performance alone does not show whether a dataset is artificial intelligence ready, whether the endpoint is clinically valid, or whether errors are unevenly distributed across patient subgroups. This article presents the Fairness-Aware Data Orchestratio...

Integrative bioinformatic analysis delineates a mitochondrial-hematopoietic gene signature for diagnosis and immune characterization in myelodysplastic syndromes.

OBJECTIVE: This study aimed to develop a mitochondrial and hematopoiesis-related differentially expressed genes (MH-related DEGs) signature for Myelod...

Large Language Models Versus Multidisciplinary Tumor Board Decisions in Thyroid Cancer.

OBJECTIVES: Large language models (LLMs) are increasingly proposed as clinical decision-support tools; however, their agreement with real-world multid...

Identification of Bacteria and Viruses by Pyrolysis-Gas Chromatography-Ion Mobility Spectrometry.

Rapid and reliable detection of biological agents is crucial in both military and civilian contexts. Here, we present a promising field-deployable app...

Explainable multi-backbone deep feature fusion based wheelchair detection with disability-aware accessibility monitoring in smart urban environments.

BACKGROUND: Reliable identification of wheelchair users in public environments is an important enabling technology for assistive systems that aids ind...

Plant uORF-pep database: A multi-evidence integrative resource for upstream open reading frames and their encoded peptides in plants.

Upstream open reading frames (uORFs) in 5' untranslated regions regulate downstream translation, and many encode functional peptides. Despite their im...

Soluble protein analog selection engine (SPASE): An automated AI-powered server to improve protein engineering workflows.

The design of proteins with desired biophysical properties, such as high solubility and low aggregation propensity, is crucial for various biotechnolo...

Silencing SLC52A2 promotes tertiary lymphoid structure formation and inhibits IL-17 pathway to ameliorate melanoma progression.

Tertiary lymphoid structure (TLS) correlates with improved prognosis in melanoma. The role of solute carrier family 52 member A2 (SLC52A2) in mediatin...

Unveiling the immuno-inflammatory endotype of sepsis-associated acute kidney injury: a machine learning-based approach.

BACKGROUND: Sepsis-associated acute kidney injury (SA-AKI) is a frequent and high-mortality complication in critically ill patients. Current diagnosti...

Machine learning-assisted design of a dendritic cell nanovaccine inducing twin immunity against monkeypox.

The global emergence of monkeypox virus (MPXV) has created an urgent need for effective vaccines that induce robust immune responses. Here, we report ...

A Retrospective Comparative Study of Concordance Between Artificial Intelligence Remedy Suggestion and Synthesis Repertory Results in Urinary Tract Infection Cases.

BACKGROUND: Homeopathic prescribing traditionally relies on detailed case taking, repertorization, and consultation of the materia medica to identify ...

Cutaneous lymphomas - an update.

Primary cutaneous lymphomas (CL) and lymphoproliferative disorders (LPD) are heterogeneous T- and B-cell neoplasms defined by integrated clinical, his...

Naïve adaptive immune receptor repertoires in celiac disease assessed by machine learning; impact of the HLA-DQ2.5 allotype on the TCR repertoire.

The adaptive immune receptor repertoire (AIRR) - the collection of an individual's B-cell and T-cell receptors (BCRs and TCRs, respectively) - encodes...

PAC-Net: A physics-guided multimodal hybrid network for antibody-antigen interaction prediction.

The precise prediction of Antibody-Antigen Interaction (AAI) is a pivotal task for accelerating antibody drug discovery and virtual screening. To addr...

The Imaging Compass: Navigating Reperfusion in Acute Ischemic Stroke.

The management of acute ischemic stroke has shifted from rigid time-based protocols to imaging-driven, tissue-based reperfusion strategies. Non-contra...

Ensuring pragmatic and equitable paths forward for hepatitis B virus infection eradication in Latin America.

INTRODUCTION: Latin America occupies a paradoxical position in hepatitis B virus (HBV) elimination: aggregate prevalence is low, yet the region remain...

Improving outdoor navigation for people with blindness using an AI-driven smartphone application and personalized audio guidance.

Globally, 340 million people have blindness or moderate-to-severe visual impairment (BVI), which limits independent outdoor navigation and negatively ...

3D interactive radiology reports: referring physicians' acceptance of artificial intelligence varies across practice settings.

INTRODUCTION: A 3D interactive report is a state-of-the-art artificial intelligence (AI) tool that integrates a patient's imaging history into an intu...

Breast tumor detection in ultrasound images using adaptive hierarchical pruning of non-tumor regions.

BACKGROUND: The development of deep learning techniques has greatly improved tumor detection and analysis in breast ultrasound images. Despite their i...