HIV/AIDS

Motion-Steered Noise Management in Hearing Aids Reduces Listening Effort and Stress Indexed by Pupil Size and Heart Rate.

OBJECTIVES: Head and body movements influence real-world hearing outcomes, yet they are often overlooked in clinical evaluations of hearing aids. This reduces ecological validity and limits assessments of motion-based features. To overcome this, the present study introduces a novel experimental approach that incorporates natural human behavior during listening, utilizing virtual reality (VR) in an...

KIMMDY: a biomolecular reaction emulator.

Molecular simulations have become indispensable in biological research. Their accuracy continues to improve, but directly modelling biochemical reactions - central to all life processes - remains computationally challenging. Here, we present a biomolecular reaction emulator that models reactions across conformational ensembles using kinetic Monte Carlo. Our method, KIMMDY, is capable of handling d...

Phenotypic prediction of missense variants via deep contrastive learning.

Missense variants (MVs) influence clinical phenotypes, but our understanding of their phenotypic consequences remains constrained. Existing computatio...

Assessing ChatGPT's capability in understanding and reporting antiretroviral therapy drug-drug interactions (ACCURATE-DDI).

OBJECTIVES: Artificial intelligence tools are transforming access to medication information. However, their ability to accurately identify antiretrovi...

Digital Monitoring of Pre-Exposure Prophylaxis Users Through Electronic Patient-Reported Outcome Measures and Electronic Patient-Reported Experience Measures: Multicenter Prospective Study on Feasibility, Safety, and Predictive Modeling of Digital Engagement.

BACKGROUND: Digital health tools integrating electronic patient-reported outcome and experience measures (ePROMs/ePREMs) enable longitudinal monitorin...

Web-Based Personalized Machine Learning Recommendations to Enhance Shared Decision-Making in Prostate-Specific Antigen Screening: Randomized Controlled Trial.

BACKGROUND: Prostate‑specific antigen (PSA) screening involves complex trade‑offs between early detection and the risks of overdiagnosis. For older ad...

Restoring auditory discrimination in noise: mismatch negativity evidence for a deep neural network-based denoising system in hearing aids.

BACKGROUND: Understanding speech in noise is a primary challenge for individuals with sensorineural hearing loss (SNHL). While deep neural network (DN...

Multidimensional Trends and AI-Based Forecasts of HIV Incidence in Korea, 1985-2024.

Investigating the potential risk of nicotine exposure on glioblastoma: Integrating Mendelian randomization and network toxicology analysis.

OBJECTIVE: To investigate the potential risk of nicotine exposure on glioblastoma multiforme (GBM). METHODS: A two-sample Mendelian randomization (MR)...

Identification and validation of KLRB1-related biomarkers in rheumatoid arthritis.

BACKGROUND: Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disorder. KLRB1 (killer cell lectin like receptor B1), which is intricatel...

Selective reuse of prior ensemble data improves the latest air temperature forecast over North America.

Accurate subseasonal to seasonal (S2S) weather forecasts are critical for managing risks to society, yet improving forecast skill remains challenging....

Machine-Learning Source Apportionment of Particulate Pollution Aids Urban Emission Regulations.

Reducing urban particulate pollution is essential for improving air quality and reducing health risks. Achieving this objective requires accurate iden...

Parent Questions About Childhood Hearing Loss: An Evaluation of ChatGPT Response Accuracy, Completeness, and Repeatability.

PURPOSE: We aimed to assess the responses to parent questions about childhood hearing loss that were generated by two generative artificial intelligen...

Assessing predictive accuracy of 2D digital templating in fluoroscopy-guided direct anterior approach total hip arthroplasty.

INTRODUCTION: Preoperative 2D digital templating aids surgical planning in total hip arthroplasty (THA). We evaluated template accuracy by comparing p...

SDS-CRISPR for Single-Nucleotide Variant Detection.

The CRISPR-Cas12a system offers a promising platform for simple and sensitive nucleic acid diagnostics, including tumor-associated variant detection a...

Fifteen Years of WRTDS for Advancing Water-Quality Science: A Review of Methodological Developments and Global Applications.

Contamination by nutrients, major ions, and metals poses a major threat to global water sustainability. Understanding how these pollutants vary across...

Comparative evaluation of feature selection methods for HRV-based survival modeling in HIV-positive ICU patients: a retrospective study.

Enthusiasm and hesitation: a structural topic modelling analysis of long-acting injectable PrEP perceptions among Dutch-speaking MSM.

BACKGROUND: Long-acting injectable PrEP (LA-PrEP) is a novel HIV prevention modality recently approved in Europe, offering an important addition to HI...

Circulating Immune Profiles in ACTH-Dependent Cushing's Syndrome.

OBJECTIVE: ACTH-dependent Cushing's syndrome (CS) causes profound immune dysfunction and severe infections. This study aimed to characterize immune ce...

CRISPR-Cas9 and next-generation gene editing strategies for therapeutic intervention of neurodegenerative pathways in Alzheimer's disease: a state-of-the-art review.

Alzheimer's disease (AD) is a progressive and multifactorial neurodegenerative disorder and the leading cause of dementia worldwide, characterized by ...