HIV/AIDS

Identification of the oxidation stress-related gene signatures and functional verification of MINK1 in prostate cancer cells.

BACKGROUND: A major challenge facing prostate cancer (PCa) cells is oxidative stress, yet the precise role and underlying mechanisms remain inadequately elucidated. The study sought to investigate the association between oxidative stress and PCa prognosis, as well as to identify potential regulatory pathways involved. METHODS: Oxidative stress-related genes and data were sourced from the Genecards...

A systematic trust management system for RPL based IoT networks using machine learning.

As IoT networks continue to evolve, concerns about their security risks are growing. Several security gaps still exist within IoT systems like Blackhole, Decreased Rank, Version Number, and Flooding attacks. During these attacks the intruder cheat legitimate nodes. Hence, affecting trustworthiness. One potential solution is the Trust Management System (TMS). TMS evaluates the trustworthiness of no...

Advances in Antiviral Drug Development Targeting Viral Proteases.

Viral proteases are critical targets in antiviral drug development due to their essential role in the viral lifecycle and high conservation across vir...

Efficacy evaluation of artificial intelligence in radiological imaging diagnosis based on randomized controlled trials: a scoping review.

OBJECTIVE: Artificial intelligence (AI) demonstrates significant potential in medical imaging diagnosis, yet its real-world clinical value requires va...

Deep learning & PSO-based optimisation of data centre energy costs using renewable sources.

In this research work, an energy management framework for a data centre powered by a combination of solar and grid energy is proposed. A service-level...

Carotid inflammation on FDG-PET is associated with lower cognitive performance in people with treated HIV infection.

OBJECTIVES: Carotid atherosclerosis is an established risk factor for cognitive impairment. FDG-PET detects subtle inflammatory changes in the arteria...

Informed Consent Disclosures and Minimum Requirements in AI Clinical Trials: Cross-Sectional Analysis.

BACKGROUND: The integration of artificial intelligence (AI) into clinical research challenges traditional informed consent (IC) frameworks due to the ...

Artificial Intelligence in Dental Practice: Current Trends and Future Perspectives.

The significance of artificial intelligence (AI) in several facets of dental care is highlighted in this paper. These days, AI is becoming more widely...

Theoretical and Psychological Mechanisms of Perceptual-Motor Learning in AI Bots-Assisted Art Education.

The integration of Artificial Intelligence (AI) into art education presents a complex shift in perceptual-motor learning, yet the psychological mechan...

Key molecular mechanisms of mitochondrial metabolic pathways in specific cell subpopulations of pancreatic cancer based on scRNA-seq and bulk RNA-seq.

BACKGROUND: Pancreatic cancer (PC) is a highly malignant tumor with increasing incidence, mortality, and a low five-year survival rate. Mitochondrial ...

Deep learning enables rabies virus detection and antibody quantification in cell culture.

Rabies remains a major neglected disease, causing tens of thousands of deaths annually in endemic regions. Cell culture-based assays are central to ra...

Machine learning reveals X chromosome transcriptional signatures that classify systemic lupus erythematosus in females.

BACKGROUND: Systemic lupus erythematosus (SLE) has a significant female bias; however, it remains unclear whether X-chromosomal dysregulation increase...

From companion technologies to social care infrastructure: A multi-level perspective on loneliness-related support in dementia care in an era of artificial intelligence (AI).

Loneliness and social isolation are important psychosocial concerns in dementia care, but they are difficult to address through pharmacological treatm...

Tree-Guided Graph Neural Networks with Multilevel Optimization for Protein-Protein Interaction Prediction.

Predicting human-virus protein-protein interactions (PPI) is crucial for revealing viral infection and disease development. Graph neural networks serv...

Operationalizing Digital Health Equity in Artificial Intelligence-Enabled Patient Decision Aids for Older Adults: Mixed Methods Study.

BACKGROUND: Artificial intelligence-enabled patient decision aids (AI-PDAs) hold promise for supporting older adults with chronic diseases in accessin...

Evaluation of a Digital Intervention for Monitoring and Improving Medication Adherence Among Real-World e-Consumers of HIV Preexposure Prophylaxis in China: Protocol for a Randomized Controlled Trial.

BACKGROUND: Preexposure prophylaxis (PrEP) is a key biomedical HIV prevention strategy that relies heavily on adherence for optimal effectiveness. In ...

Identification and validation of biomarkers associated with mitochondria and glycometabolism in gestational diabetes mellitus.

Gestational diabetes mellitus (GDM) can elevate the likelihood of developing high blood pressure during pregnancy. It is one of the most common compli...

Automated Identification of Surgical Site Infections From Electronic Medical Records: Retrospective Observational Predictive Modeling Study.

BACKGROUND: Surgical site infections (SSIs) affect 160,000 to 300,000 patients annually, increasing postoperative mortality, causing significant compl...

Diagnosing lung disorder and optimal classification using dense convolution (Dc)-CapsNet technique.

Lung carcinoma is regarded as lung cancer and is the usual form of cancers worldwide. It cannot be diagnosed easily until it spreads and is regarded a...

Rational design of an optimized ferritin nanoparticle vaccine targeting both SARS-CoV-2 and MERS-CoV.

BACKGROUND: Coronaviruses including SARS-CoV-2 and MERS-CoV remain threats to global health. Ferritin nanoparticle-based vaccines are promising platfo...