Infectious Disease

HIV/AIDS

Latest AI and machine learning research in hiv/aids for healthcare professionals.

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Bayesian Approximate Kernel Regression with Variable Selection.

Nonlinear kernel regression models are often used in statistics and machine learning because they are more accurate than linear models. Variable selection for kernel regression models is a challenge partly because, unlike the linear regression setting, there is no clear concept of an effect size for regression coefficients. In this paper, we propose a novel framework that provides an effect size a...

Jun 19 2018 30799887

Visualizing convolutional neural network protein-ligand scoring.

Protein-ligand scoring is an important step in a structure-based drug design pipeline. Selecting a correct binding pose and predicting the binding affinity of a protein-ligand complex enables effective virtual screening. Machine learning techniques can make use of the increasing amounts of structural data that are becoming publicly available. Convolutional neural network (CNN) scoring functions in...

Jun 18 2018 29940506
Marginal Structural Models with Counterfactual Effect Modifiers.

UNLABELLED: In health and social sciences, research questions often involve systematic assessment of the modification of treatment causal effect by pa...

Jun 8 2018 29883322
Utilization of a robotic mount to determine the force required to cut palatal tissue.

Determination of the material properties of soft tissue is a growing area of interest that aids in the development of new surgical tools and surgical ...

Jun 6 2018 30031950
Intelligent Network DisRuption Analysis (INDRA): A targeted strategy for efficient interruption of hepatitis C transmissions.

Hepatitis C virus (HCV) infection is a global public health problem. The implementation of public health interventions (PHI) to control HCV infection ...

May 31 2018 29860098
Sarcopenia: Beyond Muscle Atrophy and into the New Frontiers of Opportunistic Imaging, Precision Medicine, and Machine Learning.

As populations continue to age worldwide, the impact of sarcopenia on public health will continue to grow. The clinically relevant and increasingly co...

May 23 2018 29791959
ProLego: tool for extracting and visualizing topological modules in protein structures.

BACKGROUND: In protein design, correct use of topology is among the initial and most critical feature. Meticulous selection of backbone topology aids ...

May 4 2018 29728050
Computational Strategies for Dissecting the High-Dimensional Complexity of Adaptive Immune Repertoires.

The adaptive immune system recognizes antigens an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interr...

Feb 21 2018 29515569
Role of α-fetoprotein in differentiation of regulatory T lymphocytes.

The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4 lymphocytes with different proli...

Jan 4 2018 29299806
Changes in Sleep-Wake Behavior Due to Lotus () Seed and Hwang Jeong () Extracts.

We evaluated the sleep enhancement activity of the medicinal herbs valerian (), jujube (), lotus seed (), , , and baekbokryung (), which can relieve i...

Dec 31 2017 29333381
Effects of wear particles of polyether-ether-ketone and cobalt-chromium-molybdenum on CD4- and CD8-T-cell responses.

T-cells, second only to macrophages, are often considered as the potential cells involved in debris-related failure of arthroplasty. Here, we assessed...

Dec 29 2017 29541407
Depression and alcohol use disorder at antiretroviral therapy initiation led to disengagement from care in South Africa.

We sought to assess mental health at the time of antiretroviral therapy (ART) initiation and subsequent retention in care over a six-month follow-up p...

Dec 27 2017 29281681
HHV-8-associated haemophagocytic lymphohistiocytosis in a patient with advanced AIDS.

We present a patient with advanced AIDS admitted with recurrent shock of unclear aetiology, fevers, altered mental status and refractory cytopenias. H...

Dec 22 2017 29275390
Effects of docosahexaenoic acid on locomotor activity in ethanol-treated HIV-1 transgenic rats.

Binge drinking affects the onset and progression of human immunodeficiency virus (HIV)-associated neurological disorders. The HIV-1 transgenic (HIV-1T...

Dec 19 2017 29260441
Evaluation of a Urine-Based Rapid Molecular Diagnostic Test with Potential to Be Used at Point-of-Care for Pulmonary Tuberculosis: Cape Town Cohort.

Tuberculosis (TB) diagnosis among sputum-scarce patients is time consuming. Thus, a nonsputum diagnostic alternative is urgently needed. The Mycobacte...

Dec 18 2017 29269279
The right combination - treatment outcomes among HIV-positive patients initiating first-line fixed-dose antiretroviral therapy in a public sector HIV clinic in Johannesburg, South Africa.

BACKGROUND: Long-term antiretroviral therapy (ART) adherence is critical for achieving optimal HIV treatment outcomes. Fixed-dose combination (FDC) si...

Dec 18 2017 29296098
UPLC-MS/MS method for the simultaneous quantification of sofosbuvir, sofosbuvir metabolite (GS-331007) and daclatasvir in plasma of HIV/HCV co-infected patients.

Direct-acting antiviral agents (DAAs) represent the major advance in hepatitis C virus (HCV) infection treatment leading to extremely high eradication...

Dec 12 2017 29276983
What Is the most Important for Elite Control: Genetic Background of Patient, Genetic Background of Partner, both or neither? Description of Complete Natural History within a Couple of MSM.

BACKGROUND: We describe a homosexual man who strongly controlled HIV-1 for ten years despite lack of protective genetic background.

Dec 7 2017 29273355
In silico toxicity profiling of natural product compound libraries from African flora with anti-malarial and anti-HIV properties.

This paper describes an analysis of the diversity and chemical toxicity assessment of three chemical libraries of compounds from African flora (the p-...

Dec 6 2017 29277258
Modeling Anti-HIV-1 HSPC-Based Gene Therapy in Humanized Mice Previously Infected with HIV-1.

Investigations of anti-HIV-1 human hematopoietic stem/progenitor cell (HSPC)-based gene therapy have been performed by HIV-1 challenge after the engra...

Dec 1 2017 29322065
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