HIV/AIDS

Toward High-Throughput Predictive Modeling of Protein Binding/Unbinding Kinetics.

One of the unaddressed challenges in drug discovery is that drug potency determined in vitro is not a reliable indicator of drug activity in vivo. Accumulated evidence suggests that in vivo activity is more strongly correlated with the binding/unbinding kinetics than the equilibrium thermodynamics of protein-ligand interactions (PLIs). However, existing experimental and computational techniques ar...

Metastatic liver tumour segmentation with a neural network-guided 3D deformable model.

The segmentation of liver tumours in CT images is useful for the diagnosis and treatment of liver cancer. Furthermore, an accurate assessment of tumour volume aids in the diagnosis and evaluation of treatment response. Currently, segmentation is performed manually by an expert, and because of the time required, a rough estimate of tumour volume is often done instead. We propose a semi-automatic se...

Paraconsistents artificial neural networks applied to the study of mutational patterns of the F subtype of the viral strains of HIV-1 to antiretroviral therapy.

The high variability of HIV-1 as well as the lack of efficient repair mechanisms during the stages of viral replication, contribute to the rapid emerg...

Hierarchical Clustering Multi-Task Learning for Joint Human Action Grouping and Recognition.

This paper proposes a hierarchical clustering multi-task learning (HC-MTL) method for joint human action grouping and recognition. Specifically, we fo...

A Q-backpropagated time delay neural network for diagnosing severity of gait disturbances in Parkinson's disease.

Parkinson's disease (PD) is a movement disorder that affects the patient's nervous system and health-care applications mostly uses wearable sensors to...

An Expanded Analysis of Pharmacogenetics Determinants of Efavirenz Response that Includes 3'-UTR Single Nucleotide Polymorphisms among Black South African HIV/AIDS Patients.

INTRODUCTION: Efavirenz (EFV) is a non-nucleoside reverse transcriptase inhibitor prescribed as part of first-line highly active antiretroviral therap...

Lopinavir Resistance Classification with Imbalanced Data Using Probabilistic Neural Networks.

Resistance to antiretroviral drugs has been a major obstacle for long-lasting treatment of HIV-infected patients. The development of models to predict...

Machine learning based sample extraction for automatic speech recognition using dialectal Assamese speech.

Automatic Speaker Recognition (ASR) and related issues are continuously evolving as inseparable elements of Human Computer Interaction (HCI). With ass...

Efavirenz pharmacogenetics in a cohort of Italian patients.

The pharmacogenetics and pharmacokinetics of efavirenz (EFV) have been widely studied, although data in the Italian population are limited. Single nuc...

Progressive Multifocal Leukoencephalopathy with Negative JC Virus PCR following Treatment of Follicular Lymphoma: Implications for Biologics in the Era of Targeted Cancer Therapy.

Anticancer therapy predisposes patients to infections by the immunosuppression that results from treatment. Although 85% of patients with progressive ...

Intestinal helminth infections amongst HIV-infected adults in Mthatha General Hospital, South Africa.

BACKGROUND: In South Africa, studies on the prevalence of intestinal helminth co-infection amongst HIV-infected patients as well as possible interacti...

Use of Dried Plasma Spots for HIV-1 Viral Load Determination and Drug Resistance Genotyping in Mexican Patients.

Monitoring antiretroviral therapy using measurements of viral load (VL) and the genotyping of resistance mutations is not routinely performed in low- ...

A Matter of Perspective: Comparison of the Characteristics of Persons with HIV Infection in the United States from the HIV Outpatient Study, Medical Monitoring Project, and National HIV Surveillance System.

Comparative analyses of the characteristics of persons living with HIV infection (PLWH) in the United States (US) captured in surveillance and other o...

The Prevalence of HIV in Cancer Patients at the Surgical Oncology Unit of Donka University Hospital of Conakry (Guinea).

Aim. To determine the prevalence of HIV infection among patients seen at the surgical oncology unit of Donka (Conakry, Guinea). Method. We conducted a...

Classification of radiology reports for falls in an HIV study cohort.

OBJECTIVE: To identify patients in a human immunodeficiency virus (HIV) study cohort who have fallen by applying supervised machine learning methods t...

Measurement of viral load by the automated Abbott real-time HIV-1 assay using dried blood spots collected and processed in Malawi and Mozambique.

BACKGROUND: The use of dried blood spots (DBS) for HIV-1 viral load quantification can greatly improve access to viral monitoring for HIV-infected pat...

Characterization of the first-in-class T-cell-engaging bispecific single-chain antibody for targeted immunotherapy of solid tumors expressing the oncofetal protein claudin 6.

The fetal tight junction molecule claudin 6 (CLDN6) is virtually absent from any normal tissue, whereas it is aberrantly and frequently expressed in v...

Ligand-Based Virtual Screening in a Search for Novel Anti-HIV-1 Chemotypes.

In a search for new anti-HIV-1 chemotypes, we developed a multistep ligand-based virtual screening (VS) protocol combining machine learning (ML) metho...

Accurate pan-specific prediction of peptide-MHC class II binding affinity with improved binding core identification.

A key event in the generation of a cellular response against malicious organisms through the endocytic pathway is binding of peptidic antigens by majo...

Identification of dual-tropic HIV-1 using evolved neural networks.

Blocking the binding of the envelope HIV-1 protein to immune cells is a popular concept for development of anti-HIV therapeutics. R5 HIV-1 binds CCR5,...