HRT

Teriparatide for the rapid resolution of delayed healing of atypical fractures associated with long-term bisphosphonate use.

Bisphosphonates (BPs) are the most widely used drugs to treat osteoporosis. However, recent reports associated to long-term BPs use with atypical low-impact fractures and prodromal pain. It is estimated that 26% of the cases of atypical fractures associated with the long-term use of BPs show delayed healing or nonunion. Teriparatide [PTH1-34] (TPTD) is an anabolic drug shown to be effective in sti...

Exposure to Aroclor-1254 impairs spindle assembly during mouse oocyte maturation.

Polychlorinated biphenyls (PCBs), as typical environmental estrogen disruptors, are a structurally-related group of halogenated aromatic hydrocarbons that are composed of 209 isomers and present as a mixture in the environment. PCBs congener with different numbers and positions of chlorine atoms substituted on the biphenyl moiety. Aroclor-1254 is a mixture of more than 60 PCB congeners. Previous s...

CYP19A1 Genetic Polymorphisms rs4646 and Osteoporosis in Patients Treated with Aromatase Inhibitor-Based Adjuvant Therapy.

OBJECTIVE: Third-generation aromatase inhibitors (AI) are potent suppressors of aromatase activity. The aim of this study was to measure the incidence...

Machine learning reveals sex-specific 17β-estradiol-responsive expression patterns in white perch (Morone americana) plasma proteins.

With growing abundance and awareness of endocrine disrupting compounds (EDCs) in the environment, there is a need for accurate and reliable detection ...

Population pharmacokinetic/pharmacodynamic assessment of pharmacological effect of a selective estrogen receptor β agonist on total testosterone in healthy men.

BACKGROUND: LY500307 is a highly selective estrogen receptor β (ERβ) agonist, which loses its selectivity at high dose and leads to undesirable suppre...

Effect of uterine size on fertility of lactating dairy cows.

There are multiple reasons for reduced fertility in lactating dairy cows. We hypothesized that one cause of reduced fertility could be the overall siz...

Effects of xenoestrogens in human M1 and M2 macrophage migration, cytokine release, and estrogen-related signaling pathways.

Bisphenol A (BPA), bis(2-ethylhexyl)phthalate (DEHP) and di(n-butyl)phthalate (DBP) are environmental estrogens that have been associated with a wide ...

Efficient prediction of progesterone receptor interactome using a support vector machine model.

Protein-protein interaction (PPI) is essential for almost all cellular processes and identification of PPI is a crucial task for biomedical researcher...

Prediction and quantifying parameter importance in simultaneous anaerobic sulfide and nitrate removal process using artificial neural network.

The present investigation deals with the prediction of the performance of simultaneous anaerobic sulfide and nitrate removal in an upflow anaerobic sl...

Auditable CT Phenotyping Through Report-derived Radiological Observations

Medical image foundation models can predict clinical phenotypes from computed tomography (CT), but strong performance leaves open whether they read di...

Development of a Deep Learning Model for Opportunistic Screening of Osteoporosis using Chest Radiographs

Purpose Prevention and early detection of osteoporosis remains a global challenge, more so in regions like the Philippines where screening barriers ex...

Machine Learning Models for Osteoporosis Prediction: A Systematic Review and Meta-Analysis

Purpose The application of machine learning (ML) to osteoporosis prediction has expanded rapidly, yet no comprehensive meta-analysis has synthesized t...

Generative AI Models Reveal Dynamic Views of Aging (DyViA) Phenotypes in Healthy Individuals

Background and objectives: In recent years, the need to develop analytical strategies for healthy aging has assumed great importance. In this study, w...

Decoding the regulatory genetic architecture of endometriosis using AlphaGenome

Background Endometriosis is a complex, estrogen-dependent disease with a strong genetic component. Although genome-wide association studies (GWAS) hav...

Retention, not flux: endpoint confounding caps computational prediction of peptide skin penetration, with a delivery-aware reframing

Bioactive peptides are now central to cosmetic and dermatological actives, yet predicting whether a given sequence will reach its site of action in sk...

Smart AI-Powered Machine Learning Risk Assessment for Early Osteoporosis Detection for Women Bone Health

Osteoporosis is often called a silent disease because it progresses without symptoms until a fracture occurs, posing a serious, yet frequently overloo...

Distinct afferent signatures onto anterior and posterior VMHvl subdomains and their progesterone receptor-expressing neurons

Female sexual behavior is fundamentally coupled to reproductive state, requiring the dynamic and coordinated regulation of sexual receptivity and reje...

Estimating bone marrow adiposity from head MRI and identifying its genetic architecture

Bone marrow adiposity changes radically through the lifespan, but this phenomenon is poorly characterised and understood in humans. Large datasets of ...

Characterization of menopause onset and associated disease risks using large-scale electronic health records

Menopause affects over one billion women worldwide, yet remains poorly characterized at scale. We apply an ICD-10-based phenotyping algorithm to elect...

Opportunistic Bone-Loss Screening from Routine Knee Radiographs Using a Multi-Task Deep Learning Framework with Sensitivity-Constrained Threshold Optimization

Background: Osteoporosis and osteopenia are often undiagnosed until fragility fractures occur. Dual-energy X-ray absorptiometry (DXA) is the reference...