Identifying and Reporting Dependent Adult abuse

Artificial intelligence in prior authorization and coverage decisions: A systematic review of methods, evidence gaps, and future implications for patient access.

BACKGROUND: Prior authorization (PA) is intended to support appropriate use and spending of services and medications, yet 1 in 6 insured adults report PA-related problems linked to delayed care, worse access, and higher financial burden. As artificial intelligence (AI) expands in utilization management and other pharmacy benefit operations, evidence guiding responsible AI use in PA remains fragmen...

Evaluating the Accuracy, Empathy, and Readability of Generative AI Versus Registered Nurses in Discharge Planning: A Vignette-Based Study.

AIM: To compare the multidimensional performance of discharge instructions generated by generative AI (GPT-4) versus those created by clinical registered nurses across three dimensions-accuracy, empathy and readability-and to explore the impact of patient. DESIGN: A prospective, double-blind, vignette-based cross-sectional study. METHODS: Five standardized multidisciplinary discharge scenarios wer...

Beyond maximum grade: key regulatory considerations in adverse event reporting.

The therapeutic landscape of haematological malignancies has evolved rapidly with the introduction of targeted therapies, immunotherapies, and cell-ba...

AI-Assisted Sonography for the Diagnosis of Thyroid Nodules.

PURPOSE: To evaluate the diagnostic accuracy, clinical utility, and workflow integration of artificial intelligence (AI)-assisted sonography for the a...

Impact of AI-Triaged Worklists and AI-Assisted Report Generation on Radiology Turnaround Times: Prospective Real-World Study.

BACKGROUND: Radiology departments frequently manage large, heterogeneous worklists using first-in, first-out (FIFO) reporting workflows. This approach...

Smartphone-Based Fundus Imaging in Global Eye Care: Closing the Gap.

Smartphone-based fundus imaging (SBFI) is an emerging approach with potential relevance for global ophthalmic care, including in low- and middle-incom...

Machine learning for monitoring and assessment of potentially toxic elements in soils: a synthesis of spatial validation, explainability, and uncertainty.

Potentially toxic elements (PTEs) in soils pose persistent risks to ecosystems, groundwater, and food systems, creating a need for reliable spatial as...

Diagnostic Performance of Machine Learning Models for Predicting Bloodstream Infections in Large Cohorts: A Systematic Review and Meta-analysis.

INTRODUCTION: Machine learning (ML) models have been increasingly applied to support the diagnosis of bloodstream infections (BSI), particularly throu...

Machine learning prediction models for diabetic kidney disease: A systematic review and meta-analysis.

BACKGROUND: Machine learning (ML) has emerged as a promising tool for predicting diabetic kidney disease (DKD), yet the performance and clinical utili...

Towards grey-zone reliability in CA19-9 nanobiosensing: an AI-integrated molecular interface design-to-decision framework.

Mildly elevated CA19-9 levels (typically 37-300 U mL-1) define a diagnostic grey zone that fuels both patient anxiety and overdiagnosis, yet many nano...

Comparison of Machine Learning-Based Reporting with Surgeon Reporting of Postoperative Complication in Cardiothoracic Morbidity and Mortality Conferences.

BACKGROUND: Traditional morbidity and mortality (M&M) conferences incompletely capture postoperative complications, potentially limiting quality impro...

Improvement of Clinical Practice Guideline Appraisal by Human Experts and AI Agents by Using Structured Guidance: Systematic Review, Meta-Analysis, and Validation Study.

BACKGROUND: Rehabilitation clinical practice guidelines (CPGs) have increased rapidly, but inconsistent methodological quality limits their implementa...

Generative Artificial Intelligence Performance on University-Level Human Anatomy Examinations: A Structured Narrative Review and Proposed MATRIX-Anatomy Framework.

Generative artificial intelligence (GenAI) can perform strongly on written anatomy examinations, but whether such scores represent anatomical competen...

Systems pharmacology reveals type I interferon and myeloid-like B cell reprogramming as candidate druggable axes in antiphospholipid syndrome.

Antiphospholipid syndrome (APS) lacks disease-modifying targeted therapies, and its molecular heterogeneity remains poorly characterized. We employed ...

Two-dimensional to three-dimensional knee reconstruction from radiographs and fluoroscopy: A systematic review of methods and accuracy (1995-2025).

Three-dimensional reconstruction of the knee plays an important role in orthopedic surgery and clinical decision-making, enabling precise implant plan...

Ethical and Regulatory Issues in Governing AI-Enabled Software as a Medical Device: A Scoping Review.

PURPOSE: Artificial intelligence (AI)-enabled software as a medical device (SaMD) is increasingly used across clinical specialties, but its governance...

AI for tumour proportion scoring of programmed death-ligand 1 immunohistochemistry in non-small cell lung cancer: a review of commercial and non-commercial tools.

Programmed death-ligand 1 (PD-L1) expression, commonly quantified as tumour proportion score (TPS), is a key biomarker guiding immunotherapy in non-sm...

Super-resolution MRI and 2.5D deep learning for intratumoral-peritumoral radiomics in preoperative prediction of rectal cancer perineural invasion.

OBJECTIVES: Preoperative prediction of perineural invasion (PNI) in rectal cancer (RC) is challenging due to limited MRI resolution and the neglect of...

Performance of AI Chatbots in Providing EFP S3-Level Guideline-Based Information for Stage IV Periodontitis.

Benchmarking AI chatbots using structured questions derived from the EFP S3-level guideline for stage IV periodontitis showed high clarity but variabl...

MRI Evaluation of Axial Spondyloarthritis: From Early Diagnosis to Therapeutic Response Assessment.

Magnetic resonance imaging (MRI) has reshaped the evaluation of axial spondyloarthritis (axSpA), which comprises radiographic axSpA (historically anky...