Infectious Disease

Latest AI and machine learning research in infectious disease for healthcare professionals.

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Respiratory Exposure to Agriculture Dust Extract Alters Gut Commensal Species and Key Metabolites in Mice.

Exposure to agricultural dust containing antimicrobial-resistant pathogens poses significant health risks for workers in animal agriculture production. Beyond causing severe airway inflammation, pollutants are linked to intestinal diseases. Swine farm dust is rich in ultrafine particles, gram-positive and gram-negative bacteria, and bacterial components such as lipopolysaccharides (LPS; endotoxins...

May 8 2025 40344252

Interferon gamma-induced hub genes and key pathways: A study based on biological network analysis and experimental validation.

By performing a biological network analysis, we identified some hub genes, which were up- or down-regulated in the breast cancer (BC) cell line after treatment with IFN-γ. Moreover, several pathways including cytokine-cytokine receptor interaction, TNF signaling pathway, NOD-like receptor signaling pathway, and NF-κB signaling pathway were detected that their activation leads to the antiproliferat...

May 8 2025 40348089
Simultaneous initiation of dolutegravir-based antiretroviral therapy and once-weekly rifapentine and isoniazid for tuberculosis prevention in antiretroviral-naive people with HIV: an open-label, non-randomised, phase 1/2 trial.

BACKGROUND: Tuberculosis preventive treatment with 3 months of once-weekly isoniazid (900 mg) and rifapentine (900 mg; 3HP) is a recommended option fo...

May 8 2025 40349709
Classification of image-enhanced endoscopy in colon tumors.

Colorectal cancer accounts for 10% of global cancer cases in each year, making accurate evaluation and resection crucial. Imaging-enhanced endoscopy h...

May 8 2025 40336268
Deep learning-assisted analysis of single-particle tracking for automated correlation between diffusion and function.

Subcellular diffusion in living systems reflects cellular processes and interactions. Recent advances in optical microscopy allow the tracking of this...

May 8 2025 40341204
Multimodal interpretable data-driven models for early prediction of multidrug resistance using multivariate time series.

Electronic Health Records (EHRs) serve as a comprehensive repository of multimodal patient health data, combining static demographic attributes with d...

May 7 2025 40352427
A Review of Cross-Species Transmission Mechanisms of Influenza Viruses.

The cross-species transmission of influenza viruses represents a critical link in the pandemic of zoonotic diseases. This mechanism involves multi-lev...

May 7 2025 40431540
A sulfated fucopyranosyl-glucosamino-glucopyranose from marine heterotrophic Bacillus tequilensis regulates inflammatory cytokines in lipopolysaccharide-stimulated human monocyte THP-1 cells.

Marine macroalga or seaweed-associated bacterial exopolysaccharides, particularly (1 → 3)-linked β-glucans, possess potential ability to reduce inflam...

May 7 2025 40345301
Leafing a mark on immunity: Quercetin-3-O-D-glucopyranoside and quercetin-3-O-(2″,6″-digalloyl)-β-D-galactopyranoside-rich Melia azedarach L. extract's immunoinflammatory effects on an sRBC-immunized BALB/c model.

Melia azedarach L. (Meliaceae) (MA) leaves are traditionally used for inflammatory disorders, yet their immunomodulatory effects on lymphocytes remain...

May 7 2025 40345340
Development and Clinical Evaluation of a Mpox Antigen-detecting Rapid Diagnostic Test.

To address the global emergence of mpox after the 2022 epidemic, a rapid and accurate diagnostic tool is needed at the point of care to identify indiv...

May 7 2025 40345596
Technical validation of a multiplex real-time PCR for combined detection of Rift Valley fever, chikungunya, Zika and dengue viruses.

Several arthropod-borne (arbo)-viruses have overlapping symptoms, insect vectors and geographical occurrence. With little known about the importance o...

May 7 2025 40345597
Lifestyle modification programme for people living with HIV with metabolic dysfunction-associated steatotic liver disease: a randomised controlled trial.

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major cause of chronic liver disease among people living with HIV, a...

May 7 2025 40347962
Infodemic Versus Viral Information Spread: Key Differences and Open Challenges.

As we move beyond the COVID-19 pandemic, the risk of future infodemics remains significant, driven by emerging health crises and the increasing influe...

May 7 2025 40334284
Artificial Intelligence-augmented public health interventions in India.

The adoption and scaling of technology in public health settings in the Global South have traditionally been challenging. The introduction of artifici...

May 7 2025 40443397
Interpretable machine learning for early predicting the risk of ventilator-associated pneumonia in ischemic stroke patients in the intensive care unit.

BACKGROUND: The incidence of ventilator-associated pneumonia (VAP) in ischemic stroke (IS) patients is linked to a variety of detrimental outcomes. Cu...

May 7 2025 40401025
Challenges on the implementation of wastewater-based epidemiology as a prediction tool: the paradigm of SARS-CoV-2.

Wastewater Based Epidemiology (WBE) has been identified as a tool for monitoring and predicting patterns of SARS-CoV-2 in communities. Several factors...

May 6 2025 40334465
The antibacterial activity of Cornus mas L. against uropathogenic Escherichia coli strains producing extended-spectrum β-lactamase.

The emergence of uropathogenic Escherichia coli strains that produce ESBLs is a major global health issue. The purpose of this work is to examine the ...

May 6 2025 40339621
Evaluation of the Efficacy of Step-down Therapy with Oral Minocycline for Complicated Pyelonephritis Caused by Extended-Spectrum β-Lactamase-Producing Enterobacterales: A Retrospective Cohort Study.

BACKGROUND: Extended-spectrum β-lactamase-producing Enterobacterales (ESBL-E) infections present significant treatment challenges owing to limited ora...

May 6 2025 40339646
Machine Learning for Personalised Risk Assessment of HIV, Syphilis, Gonorrhoea, and Chlamydia: A Systematic Review and Meta-analysis.

BACKGROUND: Machine learning (ML) shows promise for sexually transmitted infection (STI) risk prediction, but systematic evidence of its effectiveness...

May 6 2025 40339784
Comparative Analysis of Machine Learning Models for Predicting Hospital- and Community-Associated Urinary Tract Infections Using Demographic, Hospital, and Socioeconomic Predictors.

BACKGROUND: Urinary tract infections (UTI) are among the most common infections encountered in both community and healthcare settings. Differentiating...

May 6 2025 40339918
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