Infectious Disease

Exploring Emotional Attachment to Socially Assistive Robots: A Qualitative Study Among Older Adults.

Socially assistive robots (SARs) show potential to alleviate loneliness among older adults but raise...

Retraction notice to Letter in reference to "Using machine learning for personalized prediction of longitudinal COVID-19 vaccine responses in transplant recipients" [AJT Volume 25, Issue 5, May 2025, Pages 1138-1139].

Cross-tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease.

INTRODUCTION: Apolipoprotein E (APOE) ε4 is the strongest genetic risk factor for late-onset Alzheim...

An Interpretable Machine Learning Approach to Ecologically Characterize Soil Carbon and Structure From Multi-Kingdom Microbiome, Texture and Climate.

Soil physical structure is a critical determinant of agricultural landscape resilience, yet standard...

Artificial intelligence-assisted design of MAGE-A4 ×CD16 T-cell receptor-like natural killer cell engagers.

The cancer-testis antigen MAGE-A4 is an attractive immunotherapy target due to its high expression i...

Integrating Microfluidics Chips into Vector-Borne Disease Surveillance: Technological Breakthroughs and Persistent Hurdles.

BACKGROUND: Vector-borne diseases (VBDs), such as malaria, dengue, and Zika virus infections, remain...

GANs in Peptide Drug Discovery: From De Novo Design to Multi-Property Optimization and Clinical Translation.

Peptide drugs are vital for treating intractable diseases, yet traditional discovery is limited by h...

A cross-species drug-discovery platform to accelerate the identification of lifespan-extending interventions.

We develop an integrated, high-throughput platform to evaluate pharmacological lifespan-extending in...

Redundancy-aware AI-guided discovery and experimental validation of antimicrobial peptides for infected wound treatment.

Artificial intelligence (AI) is accelerating antimicrobial peptide (AMP) discovery, but prediction-c...

Early-Life Exposure to Organophosphorus Pesticide Mixtures and Impaired Neonatal Neurodevelopment: A Cohort Study Integrating Comprehensive Multi-Omics and Machine Learning.

Early-life exposure to low-dose organophosphorus pesticide (OPP) mixtures and their impact on neonat...

Prospective economic evaluation of a predictive artificial intelligence model for sepsis: Effects on hospital costs and return on investment.

Early sepsis detection is essential for improving outcomes and reducing costs, but traditional rule-...

A data-driven approach to hepatitis C forecasting using machine learning and epidemiological models.

The hepatitis C virus is a significant global health concern and a major cause of chronic liver dise...

Artificial intelligence in Latin American hepatology: current evidence, implementation barriers, and strategic priorities.

Chronic liver diseases are an increasing cause of morbidity and mortality in Latin America, driven b...

Identification of RING finger protein-related biomarkers in sepsis based on explainable machine learning: A comprehensive analysis.

OBJECTIVE: To systematically identify RING finger protein (RNF) biomarkers with diagnostic value in ...

Development of a machine-learning risk stratification tool for vasoactive medication need after two-bolus fluid resuscitation in pediatric suspected sepsis.

BACKGROUND: Timely vasopressor initiation is critical in fluid-refractory pediatric septic shock, ye...

Discovery of two novel small-molecule series with potent SARS-CoV-2 inhibition via putative nsp13 open-state trapping.

We report the discovery of 31 SARS-CoV-2 inhibitors identified across two computational-to-experimen...

Unveiling the immuno-inflammatory endotype of sepsis-associated acute kidney injury: a machine learning-based approach.

BACKGROUND: Sepsis-associated acute kidney injury (SA-AKI) is a frequent and high-mortality complica...

Microphysiological immune-on-chip systems: engineering human immunity for precision immunotherapy, vaccine development, and autoimmune disease modelling.

Microphysiological immune-on-chip systems have emerged as transformative biomedical microdevices cap...

Infection with Western equine encephalitis virus causes severe regional glial reactivity and neurodegeneration in the hippocampus with progressive accumulation of amyloid-β.

Encephalitic alphaviruses such as Western equine encephalitis virus (WEEV) result in significant mor...

Antibiotic Resistance in Helicobacter pylori: Pathogenic Mechanisms and Eradication Barriers.

Antibiotic resistance in Helicobacter pylori is an important factor in the ineffectiveness of eradic...

Machine learning-driven drug repurposing and computational validation for Nipah virus.

The recurring Nipah virus outbreaks and the lack of effective antiviral therapies, emphasize the urg...