Infectious Disease

Associations of indoor bacterial, metabolomic, and other chemical exposures with allergic rhinitis in school-aged children.

BACKGROUND: The indoor environment has been implicated as a critical factor in the development of allergic diseases. However, the interplay among indoor microbiota, metabolites, and other environmental chemicals in relation to childhood allergic rhinitis (AR) remains underexplored, particularly in subtropical regions. This study investigates the joint associations of multi-omics profiles in classr...

Artificial intelligence-based prediction of diseases among homeless populations in Bogotá: Implications for targeted interventions.

BACKGROUND: The homeless population in Bogotá exhibits complex social and health vulnerabilities, with a high prevalence of chronic and communicable diseases such as hypertension, diabetes, tuberculosis, HIV/AIDS, and cancer. These conditions hinder epidemiological surveillance and timely public health decision-making, particularly in contexts of social exclusion. OBJECTIVE: To develop and evaluat...

Application value and challenges associated with plasma cell-free DNA metagenomic sequencing technology in the diagnosis of infections in patients with hematological disorders.

In patients with hematological disorders, the high risk of complex infections caused by immune dysfunction and intensive therapies poses a major chall...

Cyanobacteria as biochemical treasure troves: unveiling bioactive metabolites for pharmaceutical and global sustainability.

Cyanobacteria, among the most ancient and versatile microorganisms on Earth, thrive across different aquatic ecosystems, ranging from freshwater to ma...

[A two-stage model for predicting postoperative pulmonary infection in esophageal cancer patients].

Postoperative pulmonary infection (PPI) after esophageal cancer surgery occurs frequently and severely impairs patients' prognosis. Most existing pred...

[Research on electrical impedance tomography for pediatric pneumonia based on an improved radial basis function neural network].

In the diagnosis of pediatric pneumonia, the weak conductivity contrast of lung tissues leads to limited image resolution in electrical impedance tomo...

Quercetin derivatives from Camellia sinensis for the discovery of anticancer compound against P-glycoprotein-mediated multidrug resistance: a computational approach.

Cancer is an ongoing severe health complication and public health concern. Efforts have been made to overcome this; however, the emergence of multidru...

Integrative network toxicology, multiomics, and machine learning elucidate zearalenone-induced developmental toxicity mechanisms in zebrafish (Danio rerio).

Zearalenone (ZEN) is a naturally occurring environmental contaminant that is produced by fungi. Developing animals are particularly sensitive to ZEN, ...

Translational applications of artificial intelligence and machine learning for mosquito-borne disease control in low- and middle-income countries.

OBJECTIVES: To synthesize evidence on the application of artificial intelligence (AI) and machine learning (ML) for mosquito-borne disease (MBD) contr...

Protocols for genomic epidemiology and source attribution of enteric bacteria causing diarrhoeal disease across Africa.

INTRODUCTION: Enteric bacterial pathogens are a major cause of diarrhoeal disease in low-income and middle-income countries, with complex transmission...

Investigating the feasibility and acceptability of the TeleRehabilitation of balance clinical and economic Decision Support System (TeleRehaB DSS) in adults at risk of falls: study protocol for a multicentre clinical trial.

INTRODUCTION: Falls are a significant concern for older adults, particularly those with neurological, vestibular, cognitive and post-viral conditions,...

Diagnosis of Small Focal Liver Lesions (≤2 cm): A Deep Learning Approach Based on B-Mode Ultrasound and Contrast-Enhanced Ultrasound.

BACKGROUND: To develop and validate a deep learning (DL) model based on feature fusion with B-mode ultrasound (BMUS) and contrast enhanced ultrasound ...

A novel Hybrid Vision Transformer with dense attention capsule network (HVT-DACapNet) model for cotton plant disease detection.

Image processing plays a vital role in precision agriculture by enabling automated disease detection and crop health monitoring. This research present...

A fractional ABC model for hepatitisB virus transmission with forecasting of epidemic trends using neural networks.

This paper develops a fractional-order HBV epidemic model using the Atangana-Baleanu-Caputo (ABC) fractional derivative with a nonsingular Mittag-Leff...

Resolvability parameters in molecular graphs of antimalarial drugs.

Chemical graph theory facilitates the understanding of the complex structure of molecules. Researchers can achieve a thorough understanding of the phy...

Dynamic gut microbiota shift in chronic liver disease progression: machine learning models and the E/Er ratio as a predictive biomarker.

BACKGROUND: Chronic liver disease (CLD) and its progression to compensated cirrhosis (CC), decompensated cirrhosis (DC), and acute-on-chronic liver fa...

Identification of T-cell exhaustion-related biomarkers in aortic dissection via integrated multi-omics analysis and mendelian randomization.

BACKGROUND: Aortic dissection (AD) is a life-threatening cardiovascular emergency characterized by high acute mortality. While immune dysregulation is...

Bioinformatics classification of the MgtE Mg 2 + channel and de novo protein design for the stabilization of its novel subclass.

MgtE channels play crucial roles in Mg 2 + homeostasis and are implicated in bacterial survival under antibiotic exposure. Previous structural and bio...

Efficient inference of non-polyreactive antibody variants dependent on local fine-tuning.

Antibody polyreactivity, which is characterized by broad, low-affinity off-target binding, is an undesirable drug property associated with rapid clear...

Smart Systems, Saved Lives: Using AI to Identify Deteriorating Sepsis Patients in Adult Critical Care.

Sepsis remains one of the leading causes of mortality in adult critical care, representing a dysregulated host response to infection. Despite advances...