Infectious Disease

Reducing patient mortality, length of stay and readmissions through machine learning-based sepsis prediction in the emergency department, intensive care unit and hospital floor units.

INTRODUCTION: Sepsis management is a challenge for hospitals nationwide, as severe sepsis carries high mortality rates and costs the US healthcare system billions of dollars each year. It has been shown that early intervention for patients with severe sepsis and septic shock is associated with higher rates of survival. The Cape Regional Medical Center (CRMC) aimed to improve sepsis-related patient...

First Ever Use of Proton Stereotactic Body Radiation Therapy Delivered with Curative Intent to Bilateral Synchronous Primary Renal Cell Carcinomas.

Limited therapeutic options exist for inoperable bilateral kidney tumors. We report the first ever use of proton therapy to treat primary renal cell carcinoma (RCC) and the first report of proton stereotactic body radiation therapy (SBRT) for RCC in an inoperable patient with synchronous RCCs treated with proton SBRT. The patient is a 47-year-old 450-pound female with multiple medical comorbiditie...

Identification of immune signatures predictive of clinical protection from malaria.

Antibodies are thought to play an essential role in naturally acquired immunity to malaria. Prospective cohort studies have frequently shown how conti...

Antimicrobial effect of a combination of herb extract and organic acid against spores.

The sporicidal activities of the herbs were investigated to screen for novel antimicrobial substances against spores. The bacterial inactivation effe...

Occurrence and characteristics of extended-spectrum β-lactamase- and carbapenemase- producing bacteria from hospital effluents in Singapore.

One of the most important resistance mechanisms in Gram-negative bacteria today is the production of enzymes causing resistance to cephalosporin and c...

Synthesis and antifungal activity of novel oxazolidin-2-one-linked 1,2,3-triazole derivatives.

Novel oxazolidin-2-one-linked 1,2,3-triazole derivatives () were synthesized by straightforward and versatile azide-enolate (3 + 2) cycloaddition. The...

Neutrophil gelatinase-associated lipocalin level is a prognostic factor for survival in rat and human chronic liver diseases.

Chronic liver disease patients often have complications, such as hepatocellular carcinoma (HCC) and acute bacterial infection. Model for end-stage liv...

Developing a dengue forecast model using machine learning: A case study in China.

BACKGROUND: In China, dengue remains an important public health issue with expanded areas and increased incidence recently. Accurate and timely foreca...

The synthesis, biological evaluation and structure-activity relationship of 2-phenylaminomethylene-cyclohexane-1,3-diones as specific anti-tuberculosis agents.

The present study utilised whole cell based phenotypic screening of thousands of diverse small molecules against H37Rv () and identified the cyclohex...

Study the influence of culture conditions on rennin production by using solid-state fermentations.

Investigations were conducted on the production of Rennin enzyme from the fungi 3420 NRRL using Solid-State fermentation. Wheat bran was used as a su...

Ab-initio conformational epitope structure prediction using genetic algorithm and SVM for vaccine design.

BACKGROUND AND OBJECTIVE: T-cell epitope structure identification is a significant challenging immunoinformatic problem within epitope-based vaccine d...

Autonomous dynamic obstacle avoidance for bacteria-powered microrobots (BPMs) with modified vector field histogram.

In order to broaden the use of microrobots in practical fields, autonomous control algorithms such as obstacle avoidance must be further developed. Ho...

Analysis of radical scavenging active components in the fermented mycelia of .

The rates of 1,1-diphenyl-2-picryhydrazyl (DPPH)-free radical scavenging and hydroxyl radical eliminating were employed as indexes to qualitatively an...

Multiobjective differential evolution-based multifactor dimensionality reduction for detecting gene-gene interactions.

Epistasis within disease-related genes (gene-gene interactions) was determined through contingency table measures based on multifactor dimensionality ...

Self-Taught Learning Based on Sparse Autoencoder for E-Nose in Wound Infection Detection.

For an electronic nose (E-nose) in wound infection distinguishing, traditional learning methods have always needed large quantities of labeled wound i...

Teixobactin analogues reveal enduracididine to be non-essential for highly potent antibacterial activity and lipid II binding.

Teixobactin is a highly promising antibacterial depsipeptide consisting of four d-amino acids and a rare l--enduracididine amino acid. l--Enduracididi...

HashGO: hashing gene ontology for protein function prediction.

Gene ontology (GO) is a standardized and controlled vocabulary of terms that describe the molecular functions, biological roles and cellular locations...

Patchy promiscuity: machine learning applied to predict the host specificity of and .

and are bacterial species that colonize different animal hosts with sub-types that can cause life-threatening infections in humans. Source attributi...

Dose-Dependent Effects of Common Antibiotics Used to Treat on Biofilm Formation.

BACKGROUND & OBJECTIVE: especially methicillin-resistant (MRSA), represent serious nosocomial and community infections. Biofilm formation as an impo...

Upgrade Combination Response Is Limited by Prolonged Nucelos(t)ide Analogue Therapy in HBeAg-positive Chronic Hepatitis B: A Real-life Study.

Few previous studies have reported on a combination response (hepatitis B virus (HBV) DNA undetected, alanine aminotransferase normalization and hepa...