Infectious Disease

Latest AI and machine learning research in infectious disease for healthcare professionals.

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Pre-trained convolutional neural networks as feature extractors for tuberculosis detection.

It is estimated that in 2015, approximately 1.8 million people infected by tuberculosis died, most of them in developing countries. Many of those deaths could have been prevented if the disease had been detected at an earlier stage, but the most advanced diagnosis methods are still cost prohibitive for mass adoption. One of the most popular tuberculosis diagnosis methods is the analysis of frontal...

Aug 4 2017 28800442

Bow-tie signaling in c-di-GMP: Machine learning in a simple biochemical network.

Bacteria of many species rely on a simple molecule, the intracellular secondary messenger c-di-GMP (Bis-(3'-5')-cyclic dimeric guanosine monophosphate), to make a vital choice: whether to stay in one place and form a biofilm, or to leave it in search of better conditions. The c-di-GMP network has a bow-tie shaped architecture that integrates many signals from the outside world-the input stimuli-in...

Aug 2 2017 28767643
Small-Molecule Inhibitors of the NusB-NusE Protein-Protein Interaction with Antibiotic Activity.

The NusB-NusE protein-protein interaction (PPI) is critical to the formation of stable antitermination complexes required for stable RNA transcription...

Jul 25 2017 30023707
Physical and chemical stability of ceftaroline in an elastomeric infusion device.

BACKGROUND: Severe infections such as endocarditis and osteomyelitis require long-term treatment with parenteral antibiotics and hence prolonged hospi...

Jul 24 2017 31157080
Antiphospholipid Antibodies and Heart Valve Disease in Systemic Lupus Erythematosus.

Evaluation of antiphospholipid antibodies (aPL) and correlation with heart valve abnormalities among patients with systemic lupus erythematosus (SLE)....

Jul 20 2017 29549933
Biological activities of plant extracts from and : An antimalarial, antitrypanosomal and cytotoxity evaluation.

The cytotoxic, antiplasmodial, and antitrypanosomal activities of two medicinal plants traditionally used in Cameroon were evaluated. Wood of Roxb. e...

Jul 20 2017 29379367
Machine-learning-based classification of real-time tissue elastography for hepatic fibrosis in patients with chronic hepatitis B.

Hepatic fibrosis is a common middle stage of the pathological processes of chronic liver diseases. Clinical intervention during the early stages of he...

Jul 20 2017 28779596
Investigations into the physical and chemical stability of concentrated co-trimoxazole intravenous infusions.

OBJECTIVES: High dose of intravenous sulfamethoxazole and trimethoprim (co-trimoxazole) is often used in immunocompromised patients for the treatment ...

Jul 19 2017 31157078
Mapping quorum sensing onto neural networks to understand collective decision making in heterogeneous microbial communities.

Microbial communities frequently communicate via quorum sensing (QS), where cells produce, secrete, and respond to a threshold level of an autoinducer...

Jul 19 2017 28656904
Computerized detection of leukocytes in microscopic leukorrhea images.

PURPOSE: Detection of leukocytes is critical for the routine leukorrhea exam, which is widely used in gynecological examinations. An elevated vaginal ...

Jul 18 2017 28555888
Virtual-screening workflow tutorials and prospective results from the Teach-Discover-Treat competition 2014 against malaria.

The first challenge in the 2014 competition launched by the Teach-Discover-Treat (TDT) initiative asked for the development of a tutorial for ligand-b...

Jul 17 2017 28928948
Unsupervised Extraction of Stable Expression Signatures from Public Compendia with an Ensemble of Neural Networks.

Cross-experiment comparisons in public data compendia are challenged by unmatched conditions and technical noise. The ADAGE method, which performs uns...

Jul 12 2017 28711280
The antioxidant and antimicrobial activity of essential oils against spp. isolated from fish.

Natural products of plant origin, which include essential oils (EO) could be used as a growth inhibitor of pathogenic and spoilage microflora in food....

Jul 11 2017 30166897
Silver nanopaticles synthesized using the seed extract of L. and their antimicrobial mechanism and anticancer properties.

BACKGROUND: Synthesis of silver nanoparticles (AgNPs) through biological route plays an important role in their applications in the medical field, esp...

Jul 8 2017 30622419
Machine learning-enabled discovery and design of membrane-active peptides.

Antimicrobial peptides are a class of membrane-active peptides that form a critical component of innate host immunity and possess a diversity of seque...

Jul 8 2017 28728899
Leveraging machine learning-based approaches to assess human papillomavirus vaccination sentiment trends with Twitter data.

BACKGROUND: As one of the serious public health issues, vaccination refusal has been attracting more and more attention, especially for newly approved...

Jul 5 2017 28699569
A statistical framework for biomedical literature mining.

In systems biology, it is of great interest to identify new genes that were not previously reported to be associated with biological pathways related ...

Jul 4 2017 28675924
Impairment of Thyroid Function in Critically Ill Patients in the Intensive Care Units.

Unexplained hypotension in the intensive care unit is commonly attributed to volume depletion, cardiorespiratory failure, sepsis, or relative adrenal ...

Jul 1 2017 29549931
Safety, efficacy, and pharmacokinetics of single-tablet elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in virologically suppressed, HIV-infected children: a single-arm, open-label trial.

BACKGROUND: No once-daily single-tablet regimen is available for HIV-infected children under 12 years. The single-tablet, fixed-dose combination of el...

Jun 29 2017 30169223
Projections as visual aids for classification system design.

Dimensionality reduction is a compelling alternative for high-dimensional data visualization. This method provides insight into high-dimensional featu...

Jun 27 2017 30263012
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