Infectious Disease

Integrative transcriptomic and bioinformatic analyses predict candidate EMT-related genes in sepsis-associated acute lung injury.

Sepsis-associated acute lung injury (sepsis-ALI) is a complex pathological condition; its underlying mechanisms remain mostly obscure. Thus, in this study, we aimed to explore potential candidate molecular markers, infer the regulatory signaling pathways, and describe the immunological profiles of sepsis-ALI. We developed a comprehensive bioinformatics analytical workflow by combining human transc...

Entomological Surveillance and Arbovirus Screening in Mosquitoes from Central Morocco: First Detection of West Nile Virus in Culex pipiens from the Marrakech-Safi Region.

PURPOSE: Surveillance of arboviral vectors and screening for probable infection is very important for the planning of vector control programs, especially in countries where these activities are just beginning. In the present study, we conducted mosquito surveillance at 26 locations predicted to be at risk (according to our recently published study using Machine learning) in the Marrakech-Safi regi...

Reproducibility of AI-Generated Antibiotic Recommendations in Standardized Clinical Scenarios: A Proof-of-Concept Experimental Study.

BACKGROUND: Artificial intelligence (AI) tools are increasingly used to support antimicrobial prescribing, but most published literature focuses on ac...

Multifunctional Bioengineered Scaffolds and Adjunct Therapeutic Strategies for Diabetic Foot Ulcers.

Diabetic foot ulcers (DFUs) are chronic, non-healing wounds that affect up to 34% of diabetic patients. DFUs are complicated by infection in nearly 60...

A multidimensional risk prediction framework for malignant intestinal obstruction based on machine learning: computational model development and clinical validation.

Malignant intestinal obstruction (MIO) is a severe complication of advanced cancer. Traditional static assessment models struggle to capture its dynam...

Early cell-wall stress signatures enable 20-min ATR-FTIR discrimination of MRSA and MSSA.

Rapid identification of methicillin-resistant Staphylococcus aureus (MRSA) is crucial for early optimization of antibiotic treatment, but current rout...

The current state of demographic subgroup reporting for commercially available AI for radiology: a scoping review.

OBJECTIVE: Though subgroup performance reporting helps ensure the safety of artificial intelligence (AI) products, the extent of this reporting remain...

Radiomics-driven prediction of postoperative infection risk in maxillofacial fractures: multidimensional risk factor analysis and model construction based on absorbable plate fixation.

OBJECTIVES: This study proposes a predictive model that integrates radiological features with multidimensional clinical factors for the accurate predi...

Comprehensive molecular analyses of a circadian rhythm-related gene diagnostic model and immune infiltration using machine learning methods in sepsis-associated acute kidney injury.

BACKGROUND: This study aimed to explore hub circadian rhythm-related genes (CRRGs) associated with sepsis-associated acute kidney injury (saAKI) using...

Ranked placement of phage predation as a determinant of dehydration severity among cholera patients in Bangladesh.

Virulent bacteriophages (phages) can kill bacterial prey, potentially reducing burden of infection. In cholera, a high phage to Vibrio cholerae ratio ...

Hierarchical Amplification-Interlinked CRISPR-Cas14a Luminescent Biosensor Coupled with Portable Photonic Crystal Biochip-Boosted Time-Delayed Signaling for the Diagnosis of Pediatric Mycoplasma pneumoniae Pneumonia.

Mycoplasma pneumoniae pneumonia (MPP) is a respiratory infection that readily propagates within pediatric populations, and thus, the development of a ...

Infections in Burn Patients: Pathophysiology, Prevention, and Contemporary Therapeutic Strategies in the Era of Antimicrobial Resistance.

Burn injuries are associated with significant morbidity and mortality, largely driven by infectious complications. Disruption of the skin barrier, sys...

Mass cytometry reveals complex neutrophil heterogeneity in patients with severe sepsis.

RATIONALE: Sepsis is a state of life-threatening organ dysfunction in the setting of infection. It is biologically heterogeneous, as evidenced by whol...

Global density and biomass of arbuscular mycorrhizal fungal networks.

Arbuscular mycorrhizal fungi form symbioses with ~70% of plant species, building hyphal networks that exchange nutrients for host-derived carbon. Thes...

Operationalizing One Health Surveillance for Tropical Fungal Diseases: Practical Implications of Bioinformatics for Clinical and Epidemiological Practice.

Fungal infections are an increasing global public health concern yet remain underprioritized because of persistent challenges in diagnosis, treatment,...

A decade of progress towards the elimination of hepatitis C: from the National Strategic Plan to Artificial Intelligence.

Oral and Maxillofacial Surgery research hotspots and emerging trends in 2025: A targeted bibliometric analysis.

OBJECTIVES: To perform a targeted bibliometric analysis of the Oral and Maxillofacial Surgery (OMFS) literature from 2025 to map its current intellect...

Identification of Novel Diagnostic Biomarkers and Host-Directed Drug Screening for Mycobacterium avium Infection: A Multi-Omics and Artificial Intelligence Study.

OBJECTIVE: The rising incidence of Mycobacterium avium (MAV) infection poses significant challenges due to diagnostic delays and refractory treatment....

High-throughput analysis of multimodal monitoring data: the role of machine learning in early warning systems for high-risk neonates.

The neonatal intensive care unit (NICU) generates vast amounts of high-throughput, multimodal monitoring data, offering unprecedented potential for id...

Biofilm-mediated antibiotic tolerance in bacterial pathogens: Integrated molecular networks and novel therapeutic avenues.

The stable structure of biofilms and the characteristics of the bacteria within them make biofilms an important barrier for bacteria to resist externa...