Infectious Disease

Latest AI and machine learning research in infectious disease for healthcare professionals.

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Clinical and Cross-Domain Validation of an LLM-Guided, Literature-Based Gene Prioritization Framework

Background: We previously published a literature based pipeline for sepsis gene prioritization (PS3 and candidate genes) using an LLM enabled retrieval and judging framework. Here, we extend that work to ask whether these prioritized genes show independent clinical validity and whether the same strategy generalizes to a "drug/obesity/infection" setting. Methods: Using the original LLM guided workf...

AI-Powered Acoustic Surveillance for Early Detection of Calf Respiratory Disease

Effective management of Bovine Respiratory Disease Complex (BRDC) requires timely, non-invasive diagnostic tools to protect calf health and welfare. Among early clinical signs, coughing stands out as both frequent and informative. To explore its potential for early BRDC detection, we deployed an artificial intelligence driven acoustic monitoring system that recorded over 2730 hours of audio during...

Quantifying the oxygen preferences of bacterial communities using a metagenome-based approach

Oxygen is a primary driver of the distribution and activity of microbial life. Since oxygen levels are often difficult to measure in situ, one potenti...

Technical Acquisition Parameters Dominate Demographic Factors in Chest X-ray AI Performance Disparities: A Multi-Dataset External Validation Study

Artificial intelligence systems for chest radiograph interpretation are increasingly deployed in clinical practice, yet current fairness frameworks em...

AMPBAN: A Deep Learning Framework Integrating Protein Sequence and Structural Features for Antimicrobial Peptide Prediction

The escalating crisis of antimicrobial resistance poses a devastating and immediate threat to human life. Antimicrobial peptides (AMPs) are a promisin...

Neural Spectral Prediction for Structure Elucidation with Tandem Mass Spectrometry

Structural elucidation using untargeted tandem mass spectrometry (MS/MS) has played a critical role in advancing scientific discovery. However, differ...

Computational Discovery of CRISPR-Cas13b Guide RNAs for Broad-Spectrum Dengue Virus Targeting

Dengue (DENV), an RNA virus, remains a significant global health threat, particularly in developing regions, with no widely effective antiviral therap...

UniRoute: Unified Routing Mixture-of-Experts for Modality-Adaptive Remote Sensing Change Detection

Current remote sensing change detection (CD) methods mainly rely on specialized models, which limits the scalability toward modality-adaptive Earth ob...

Jan 21 2026 2601.14797v1
Transformer based Multi-task Fusion Network for Food Spoilage Detection and Shelf life Forecasting

Food wastage is one of the critical challenges in the agricultural supply chain, and accurate and effective spoilage detection can help to reduce it. ...

Jan 20 2026 2601.13665v1
Attention-Based Offline Reinforcement Learning and Clustering for Interpretable Sepsis Treatment

Sepsis remains one of the leading causes of mortality in intensive care units, where timely and accurate treatment decisions can significantly impact ...

Jan 20 2026 2601.14228v1
COLLEMBOT: AI-Based Counting of Collembola for OECD 232 Tests

Ecotoxicological tests with soil organisms, such as the collembolan Folsomia candida, are essential for assessing chemical risks in terrestrial ecosys...

GEOGRAPHIC DOMAIN SHIFT PRECIPITATES DIVERGENT FAILURE MODES IN DEEP LEARNING BASED TUBERCULOSIS SCREENING: A MULTI-NATIONAL EXTERNAL VALIDATION STUDY

Background: Deep learning algorithms for tuberculosis (TB) screening frequently achieve radiologist-level performance during internal evaluation, yet ...

AVP-Pro: An Adaptive Multi-Modal Fusion and Contrastive Learning Approach for Comprehensive Two-Stage Antiviral Peptide Identification

The accurate identification of antiviral peptides (AVPs) is crucial for novel drug development. However, existing methods still have limitations in ca...

Jan 16 2026 2601.11028v1
Representation-Aware Unlearning via Activation Signatures: From Suppression to Knowledge-Signature Erasure

Selective knowledge erasure from LLMs is critical for GDPR compliance and model safety, yet current unlearning methods conflate behavioral suppression...

Jan 15 2026 2601.10566v1
Achieving Expert-Level Clinical Infection Detection with LLMs from Clinical Documents: Validation in Complex Patient Cases with Cirrhosis

BackgroundSystemic infections are a leading cause of hospitalization and death among patients with cirrhosis. Timely and accurate infection identifica...

Label-free detection of individual virus-infected cells using deep learning

Numerous applications in research and medicine rely on reliable identification and quantification of virus-infected cells. Current methods either appl...

HERMES: Holographic Equivariant neuRal network model for Mutational Effect and Stability prediction

Accurately predicting how amino acid substitutions alter protein function is a central challenge in biology, with applications from interpreting disea...

Explainable Deep Learning for Pediatric Pneumonia Detection in Chest X-Ray Images

Background: Pneumonia remains a leading cause of morbidity and mortality among children worldwide, emphasizing the need for accurate and efficient dia...

Jan 14 2026 2601.09814v1
Prediction of peripheral blood lymphocyte subpopulations after renal transplantation.

Immune monitoring is essential for maintaining immune homeostasis after renal transplantation (RT). Peripheral blood lymphocyte subpopulations (PBLSs)...

Dec 1 2025 40369954
Detection of S1 spike protein in CD16+ monocytes up to 245 days in SARS-CoV-2-negative post-COVID-19 vaccine syndrome (PCVS) individuals.

Despite over 13 billion SARS-CoV-2 vaccine doses administered globally, persistent post-vaccination symptoms, termed post-COVID-19 vaccine syndrome (P...

Dec 1 2025 40358138
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