Infectious Disease

Deterioration of immunization resilience: A Bayesian machine learning assessment of the 2025-2026 measles outbreak in Mexico.

OBJECTIVE: The 2025 measles outbreak in Mexico (5741 cases) marked a severe decline in immunization ...

Parsimonious and explainable biomarker-based severity score for hospitalised patients with COVID-19-related respiratory infections: development, validation and XAI benchmarking.

BACKGROUND: Severity scoring systems are increasingly important tools for stratifying hospitalised p...

Integration of transcriptomic data identifies CD163 as a key link between chronic rhinosinusitis with nasal polyps and COVID-19.

BACKGROUND: Emerging evidence has highlighted a potential link between chronic rhinosinusitis with n...

CRISPR-Cas system: recent advancements in prompt diagnosis of high-risk HPV genotypes in cervical cancer.

INTRODUCTION: The CRISPR/Cas system has emerged as a highly versatile platform for diagnosing infect...

Data-Driven Bioprocess Optimization: Lipase Production by Aspergillus Niger ATCC 1004 in COCOA and Palm Oil Byproducts Based Solid State Fermentation.

mRNA vaccines in cancer immunotherapy: current progress and perspectives in solid tumors and hematologic malignancies.

The unprecedented success of mRNA vaccines during the COVID-19 pandemic has accelerated the developm...

Deep-Learning Algorithm Diagnostic Support for Usual Interstitial Pneumonia Pattern Recognition in Fibrotic Interstitial Lung Disease.

BACKGROUND AND OBJECTIVE: High resolution computed tomography (HRCT) scan diagnostic classification ...

Bulk Microarray and Single-Cell Transcriptomic Analyses Reveal Bacterial Lipopolysaccharide-Related Biomarkers in Sepsis.

Sepsis, a life-threatening condition triggered by dysregulated host response to infection, poses sig...

The Evaluation of Machine Learning Models Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF-MS) Spectra for the Prediction of Antibiotic Resistance in Klebsiella pneumoniae.

Antimicrobial resistance in Klebsiella pneumoniae poses a major clinical challenge, driving developm...

A metabolite-augmented FIB-4 machine learning panel achieves superior liver fibrosis staging in chronic liver disease.

Accurate, non-invasive liver fibrosis detection is essential for chronic liver disease management, p...

DIGITAL SOLUTIONS FOR TUBERCULOSIS SURVEILLANCE AND CONTROL IN PRIMARY HEALTH CARE: A SCOPING REVIEW.

Digital solutions are essential for eliminating tuberculosis as a public health problem. They can be...

Short-chain fatty acid-producing microbes differentiate non-infectious and infectious neutropenic fever in leukemia.

UNLABELLED: Neutropenic fever (NF) is often the first sign of infection in patients with hematologic...

Optimizing Machine Learning-Based Diagnosis of Neurosyphilis in HIV-Negative Patients: A Multicenter, Real-World Comparison of International Diagnostic Criteria.

AbstractNeurosyphilis continues to rise globally, yet diagnosis remains challenging, often requiring...

Machine learning-guided rational engineering of ACE2-derived peptides for broad-spectrum neutralization of SARS-CoV-2 variants.

The dynamic mutational landscape of SARS-CoV-2, especially within the spike glycoprotein's RBD, cont...

Federated Learning Framework for Privacy-Preserving Explainable AI-Driven Clinical Decision-Making.

The application of artificial intelligence (AI) in clinical diagnostics has shown substantial potent...

Complex-valued proximal neural network method for solving complex-valued mixed variational inequalities.

This paper proposes a complex-valued proximal neural network (CPNN) method for solving complex-value...

Machine learning and probabilistic approaches for forecasting infectious disease transmission and cases.

OBJECTIVES: Forecasting the effective reproductive number (Rt) and infection case counts is critical...

The oral-gut microbiome axis in diabetes mellitus: a systematic review and emerging clinical perspectives.

Emerging evidence suggests that diabetes mellitus (DM) is not only a metabolic disorder but also a m...

Transformer-based super-resolution lung CT images improve visualization of multiple diseases.

OBJECTIVES: To assess the Transformer-based Swin2SR model for super-resolution (SR) enhancement of l...

Revisiting the NETs-CYBB-p38 MAPK axis in bronchiectasis: The underlying oxidative injury mechanism.

BACKGROUND: Bronchiectasis is a chronic neutrophilic respiratory disease frequently complicated by P...

Rational Design of Broad-Spectrum Non-Nucleoside Reverse Transcriptase Inhibitors via Pharmacophore-Oriented Generative Artificial Intelligence.

Guided by the pharmacophore-oriented molecular generation platform PhoreGen, we employed rilpivirine...