Infectious Disease

Drug repurposing against viral infections (2020-2025): clinical trials, computational strategies, and therapeutic interventions.

Metagenomic analysis of the gut microbiota in Cryptosporidium-infected Tibetan sheep.

Cryptosporidium are important causative parasitic protozoa that cause gastrointestinal discomfort an...

Biotechnology advances and the parasitology paradigm: From genomes to multi-omics and translation.

Parasitic diseases impose a substantial and often underestimated burden on human and animal health, ...

Optimising pandemic response through vaccination strategies using neural networks.

Epidemic risk assessment poses inherent challenges, with traditional approaches often failing to bal...

Temporal Learning with Dynamic Range (TLDR) for modeling recurrent exposure and treatment outcomes.

The temporal sequence of clinical events is crucial in outcomes research, yet standard machine learn...

Enzyme-constrained genome-scale model of Yarrowia lipolytica predicts growth-phase specific metabolic engineering targets.

The oleaginous yeast Yarrowia lipolytica has been gaining increasing importance as an industrial bio...

Antimicrobial discovery from underexplored environments: unlocking specialized metabolism.

The discovery of antibiotics transformed modern medicine and extended the average human lifespan by ...

Integrated single-cell and bulk transcriptomic analysis identifies epithelial cell-related biomarkers and immune subtypes in focal segmental glomerulosclerosis.

BACKGROUND: Focal segmental glomerulosclerosis (FSGS) is a major cause of nephrotic syndrome and chr...

Nanogels for the targeted delivery of antibiotic and antimicrobial drugs.

Nanoparticle-based drug delivery systems represent a promising platform for advancing biomedical the...

The plastisphere as a nexus for antimicrobial resistance: micro(nano)plastics in pathogen colonization, gene transfer, and global health risks.

Microplastics (MPs) and nanoplastics (NPs) have emerged as pervasive vectors of antimicrobial resist...

Reclaiming the writing process using AI: a scaffolded writing assignment that promotes critical thinking, reflection, and accountability.

As the educational landscape changes with the widespread use of generative artificial intelligence (...

The Impact of Evaluation Strategy on Sepsis Prediction Model Performance Metrics in Intensive Care Data: Retrospective Cohort Study.

BACKGROUND: The prediction of the onset of sepsis, a life-threatening condition resulting from a dys...

Differential Factors Associated With the Presence of Persistent Symptoms in Individuals Diagnosed With Long COVID: Protocol for a Longitudinal Matched Case-Control Study.

BACKGROUND: Long COVID (postacute sequelae of SARS-CoV-2 infection) is a heterogeneous condition wit...

Quaternized polysaccharides: A focused review on molecular engineering, antimicrobial mechanisms, and advanced applications.

The escalating threat of antibiotic resistance has intensified the search for sustainable antimicrob...

Biogeochemical and genomic drivers of groundwater DNRA: predictability of ammonium accumulation risk.

Widespread ammonium (NH4+-N) contamination in groundwater, with local concentrations exceeding 20 mg...

Severe COVID-19 in the Republic of Korea: Epidemiology, Risk Factors, Therapeutics, and Prognostic Models From Nationwide Data.

Severe coronavirus disease 2019 (COVID-19) has posed ongoing clinical and public health challenges w...

Artificial Intelligence in hepatology: A position paper by the Italian Association for the Study of the Liver.

Artificial Intelligence (AI) is transforming medicine, providing unprecedented opportunities to enha...

The role of digital tools and artificial intelligence in supporting antimicrobial stewardship: Study protocol for a systematic review.

INTRODUCTION: Since the post-antibiotic era, there has been significant difficulty in treating infec...

D-LIM: A neural network for interpretable gene-gene interactions.

Recent advances in gene editing can produce large genotype-fitness maps for targeted genes, yet pred...

Artificial Intelligence Applications in COVID-19-Associated Coagulopathy: Lessons Learned.

Coronavirus disease 2019 (COVID-19)-associated coagulopathy (CAC) is a thromboinflammatory syndrome ...

Stage-dependent gut microbiome and functional signatures across the liver disease spectrum: an integrative multicohort study.

BACKGROUND: The gut-liver axis plays a critical role in liver disease progression; however, how gut ...