Inflammatory Bowel Disease

Familial colorectal cancer: risk factors, screening strategies and personalized medicine.

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with approximately 25-30 % of cases exhibiting a familial component driven by germline mutations in DNA mismatch repair genes (Lynch syndrome) or the APC gene (familial adenomatous polyposis). Despite advances in screening and early detection, significant challenges persist in identifying at-risk individuals, op...

Machine learning and metabolic signatures of drowning: A pathway to uncovering cause of death in aquatic environments.

The postmortem diagnosis of drowning is challenging due to the nonspecific and transient nature of classical autopsy findings. This study aimed to investigate whether postmortem metabolomics can differentiate drowning from other causes of death, offering a potential biochemical tool to support forensic diagnosis in water-related deaths. A total of 503 drowning cases and four control groups were in...

CT-derived sarcopenia and myosteatosis predict treatment escalation in hospitalized patients with inflammatory Bowel disease.

BACKGROUND: Sarcopenia and myosteatosis reflect muscle quantity and quality and are linked to adverse outcomes in chronic diseases. Their role in pred...

Noninvasive diagnosis of colorectal adenoma: The emerging potential of blood-based biomarkers.

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the second leading cause of cancer-related death globally. Most CRCs arise fro...

Optimal management of oligometastatic prostate cancer: current state and future directions.

PURPOSE: Oligometastatic prostate cancer (oligoPCa) represents a clinical state of limited metastatic spread in which metastasis-directed therapy (MDT...

Artificial intelligence-supported polyp detection (CADe) at colonoscopy reduces the detection of high grade dysplasia and invasive cancer.

Immunotherapy in Triple-Negative Breast Cancer: From Molecular Mechanisms to Precision Medicine-Overcoming Resistance and Optimizing Clinical Outcomes.

Triple-negative breast cancer (TNBC) is the most violent type of breast cancer, in which estrogen receptors (ER), progesterone receptors (PR), and hum...

Machine Learning Prediction of Recurrence in Pediatric Thyroid Cancer: Malignant Endocrine Tumors Cohort Analysis Using XGBoost and SHAP.

CONTEXT: Pediatric differentiated thyroid carcinoma (DTC) often presents with advanced disease but generally has excellent long-term survival. However...

Outer Retinal Erosion and Outer Retinal Pinching at the Origin of Subretinal Fluid in Central Serous Chorioretinopathy.

PURPOSE: To characterize early outer retinal changes at the site of origin of subretinal fluid (SRF) in central serous chorioretinopathy (CSCR). To in...

NPHS2 Revisited Through 208 Cases and Podocin Complex Modeling.

INTRODUCTION: Steroid-resistant nephrotic syndrome (SRNS) is the leading cause of chronic glomerular disease in individuals under 25 years of age. Bia...

The optimal conditioning intensity of stem cell transplantation for acute myeloid leukemia in complete remission.

UNLABELLED: This study aimed to identify patient groups in which myeloablative conditioning (MAC) or reduced-intensity conditioning (RIC) regimens ind...

Exploring an Intermediate Colorectal Cancer Screening Test Based on Stool Proteomics and Machine Learning for Optimizing the Selection of Patients for Colonoscopy Identified from FIT.

The fecal immunochemical test (FIT) for detecting fecal occult blood, used alone or in combination with other stool biomarkers, has been demonstrated ...

Identifying Transdiagnostic Predictors of Depression Across Psychoses: Informing Stratified Antidepressant Treatments.

INTRODUCTION: Depression frequently co-occurs with psychosis and is associated with poor outcomes. Early identification of patients at risk of persist...

[AI and clinical reasoning : between promises and the risks of "deskilling"].

The rise of AI in healthcare offers major potential for diagnosis and learning but also exposes to a worrying risk of "deskilling." Recent data from c...

Letter Regarding "Artificial Intelligence Model for Automated Identification of Bowel Preparation for Colonoscopy (AI-PREPOO): A Multicenter Study".

Artificial intelligence enhances screening efficiency for inflammatory bowel disease clinical trials: a prospective study.

An LLM-based AI tool significantly improved identification of potentially eligible patients and screening efficiency for IBD clinical trials, outperfo...

Contemporary Management of Radiation Necrosis: Insights and Avenues.

Radiation necrosis (RN) remains a challenging complication of upfront radiation therapy for both brain metastases and primary tumors. Despite developm...

An odyssey of monoclonal gammopathies: focusing on precursors and the progression from MGUS and SMM to multiple Myeloma, with a brief overview of novel therapeutic strategies.

Monoclonal gammopathies span a continuum from monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) to overt...

Serum metabolomic signatures of relapse recovery in early multiple sclerosis.

BACKGROUND: Relapses in relapsing-remitting multiple sclerosis (RRMS) are acute neuroinflammatory events that shape long-term disease trajectory. Yet,...

AI-Enhanced Vibrational Capsule for Minimally Invasive Detection of Abnormal Bowel Tissue.

Colorectal cancer remains one of the leading causes of cancer mortality, and its prognosis is strongly dependent on early detection. Conventional diag...