Inflammatory Bowel Disease

Machine Learning Analysis of Serum Metabolomics for Multi-Disease Classification and Proteome-Metabolome Pathway Insights in T2D, IBD, and CRC.

Type 2 diabetes (T2D), inflammatory bowel disease (IBD), and colorectal cancer (CRC) share overlapping metabolic alterations that hinder early, disease-specific diagnosis. Using publicly available serum metabolomics data sets (T2D: ST003390; IBD: ST003312; CRC: ST000284), a standardized workflow combining random forest-based imputation, log transformation, Pareto scaling, and ComBat batch correcti...

IL11⁺ fibroblasts are implicated in non-response to anti-TNFα via fibrosis in inflammatory bowel disease.

Inflammatory bowel disease (IBD) is frequently accompanied by intestinal fibrosis, with non-response (NR) to long-term anti-tumor necrosis factor α (anti-TNFα) therapy occurring in approximately 23-46% of patients. Integrated analysis of single-cell and bulk RNA sequencing datasets revealed an expansion of IL11⁺ fibroblasts in inflamed intestine and their significant enrichment in non-responders. ...

Calculation and evaluation of the effective withdrawal time of colonoscopy on the basis of internimage.

Flexible IMU Sensor Array For 3D Colonoscope Shape Reconstruction and AI-Based Loop Detection.

Looping during colonoscopy procedures is a major cause of patient discomfort and increases the risk of complications. With the rising incidence of col...

Delineating Pediatric Adrenocortical Tumors by GC-MS Urinary Steroid Metabolome Analysis: Observations From the MET Study.

INTRODUCTION: Adrenocortical tumors (ACTs) comprise adrenocortical adenomas (ACAs) and adrenocortical carcinomas (ACCs); the latter are highly aggress...

Graves' disease: a new era of pathophysiology-guided therapeutics.

Graves' disease (GD) is an autoimmune entity that had an unchanged treatment paradigm for more than half a century with radioactive iodine, antithyroi...

Colorectal cancer detection using noncontrast CT and deep learning: a multicenter and international cohort study.

BACKGROUND: Colorectal cancer (CRC) is a leading cause of cancer deaths, with early screening vital to reduce mortality. While methods such as colonos...

From Time-Limited Therapy to Treatment-Free Observation: The Evolving Role of MRD in CLL Management.

The integration of measurable residual disease (MRD) into the management of chronic lymphocytic leukemia (CLL) has emerged as a major advance in risk ...

Personalizing treatment of pancreatitis-associated chronic pain: the need for an integrated omics approach.

BACKGROUND: Chronic pancreatitis (CP) is a progressive inflammatory disorder characterized by debilitating chronic pain and substantial healthcare bur...

Overcoming barriers to delivery of biologics by novel approaches and, advanced delivery systems.

Biologics is emerging as fastest growing field of drug development offering specificity and high therapeutic potential. However, their therapeutic eff...

Inflammatory bowel disease burden in China and the United States from 1990-2023 and prediction to 2050.

BACKGROUND: Inflammatory bowel disease (IBD) shows divergent epidemiological trends in China and the United States, necessitating country-specific for...

Artificial allosteric protein switches with machine-learning-designed receptors.

Protein allostery underlies most information and energy processing in biology and the development of artificial allosteric proteins is a key objective...

Identification and Validation of Transcriptomic Signatures in Inflammatory Bowel Disease with Metabolic Syndrome via Bioinformatics and Machine Learning.

BACKGROUND: Inflammatory bowel disease (IBD) is a chronic, nonspecific inflammatory disorder affecting the gastrointestinal tract. The condition's pat...

Imaging Immune Heterogeneity in Nasopharyngeal Carcinoma: A Multidimensional Radiomics Perspective.

RATIONALE AND OBJECTIVES: Nasopharyngeal carcinoma (NPC) is characterized by a distinctive virologic and immunologic profile, in which Epstein-Barr vi...

Using Large Language Models to Determine Reasons for Missed Colon Cancer Screening Follow-Up.

BACKGROUND: Identifying reasons for missed preventive care, such as follow-up colonoscopy after an abnormal stool-based colon cancer screening test, i...

Trusted polyp segmentation via multi-scale evidence ensemble in colonoscopy images.

PURPOSE: Accurate and reliable polyp segmentation is essential for early colorectal cancer detection. Although recent methods employing multi-scale fe...

Relationships between periodontitis and inflammatory bowel disease: Screening and functional analysis of endoplasmic reticulum stress-related biomarkers.

This study aimed to explore the relationship between periodontitis (PD) and inflammatory bowel disease (IBD), focusing on changes in the expression of...

Imaging and genomics in stroke.

Imaging after ischemic and hemorrhagic stroke may allow measurement of key phenotypes of injury and recovery for which targeted therapies are still la...

Baseline pain, fatigue, and sleep quality predict 12-week pain improvement in inflammatory arthritis: retrospective real-world analysis of a digital health application cohort.

UNLABELLED: Despite advances in pharmacotherapy, many patients with inflammatory arthritis (IA) experience residual pain even in remission. Digital he...

Volatomics-based biomarkers for non-invasive diagnosis and monitoring of inflammatory bowel disease.

BACKGROUND: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic disorder that markedly impairs quality of...