Inflammatory Bowel Disease

AI in Healthcare: How Relevant to Medical Risk Selection?

The role of artificial intelligence (AI) in biologic discovery, and in the practice of medicine is rapidly increasing. AI-assisted analyses of large databases are leading to impressive biologic discoveries and AI-diagnostics are beginning to change clinical practice. With time, AI-generated content will become a substantive component of electronic health records. By extension, more risk-relevant i...

Update on Non-Biological and RNA-Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules.

In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way-through the clinical use of monoclonal antibodies-a deeper understanding of how inflammatory a...

Machine Learning Models for Posttransplant Lymphoproliferative Disorder (PTLD) Risk Prediction in Thoracic Transplantation.

Posttransplant lymphoproliferative disorder (PTLD) is the second most common malignancy in thoracic transplant recipients and is associated with poor ...

Pharmacological Nuances and Epigenetic Precision: Critical Additions to Plasma Protein-Targeted IBD Research.

Auditory and Vestibular Recovery in Otosclerosis Surgery: Clinical Efficacy and Predictive Modeling of Intraoperative Corticosteroid Use.

OBJECTIVE: To evaluate the effect of intraoperative local corticosteroid application on hearing, tinnitus, and dizziness outcomes after stapes surgery...

Prediction of remission in cushing's disease using artificial intelligence: A systematic review and meta-analysis.

Controversies in Computer-Assisted Detection in Colonoscopy.

BACKGROUND: Artificial intelligence (AI) applications in endoscopy, particularly computer-aided detection (CADe), have shown consistent benefit in ran...

Optimizing vedolizumab therapy in ulcerative colitis: A critical synthesis of trial evidence and the emerging role of artificial intelligence.

BACKGROUND: Vedolizumab, a monoclonal antibody targeting the α4β7 integrin, offers gut-selective immunosuppression and represents a cornerstone biolog...

Effectiveness of AI-enhanced colonoscopy: A case-control study using real world evidence in a young screening age population.

BACKGROUND: Computer aided detection (CADe) colonoscopy has been shown in randomized controlled trials to improve detection of adenomatous colorectal ...

Contrasting land-use sources of microplastic and endocrine-disrupting compound pollution in a major coastal river network.

Environmental monitoring in coastal megacities prioritizes land-based microplastics (MPs) and endocrine-disrupting compounds (EDCs) as key threats to ...

Predicting Treatment Outcomes in Patients With Psoriatic Arthritis or Axial Spondyloarthritis: An Artificial Intelligence-Driven Approach.

OBJECTIVE: To develop machine learning (ML) models to predict the probability at baseline of achieving low disease activity (LDA) and high health-rela...

Machine Learning-based Prediction of Mortality Among Malnourished Patients Hospitalized With Inflammatory Bowel Disease.

BACKGROUND: Malnourished patients hospitalized with inflammatory bowel disease (IBD) have a high risk of morbidity and mortality. Risk stratification ...

Pubertal Hormones and the Early Adolescent Female Brain: A Multimodality Brain MRI Study.

Puberty is a critical developmental process that is associated with changes in pubertal (or steroid) hormone levels, which are believed to influence a...

Impact of Artificial Intelligence for Detection of Precancerous Colonic Lesions in a Fecal Immunochemical Blood Test-Based Organized Screening Program in Italy: A Randomized Control Trial.

BACKGROUND: The fecal immunochemical test (FIT) is widely implemented as a first-line tool in organized colorectal cancer (CRC) screening programs, in...

Changing the container closure system of lyophilized products: Real or perceived risk to process efficiency and product quality?

The container-closure system (CCS), specifically the glass vial, plays a pivotal role in heat transfer during lyophilization, thereby influencing proc...

State of the art in soft eversion robots for colonoscopy: a review.

This review explores the current state of eversion robotics in the context of colonoscopy, given the need for less invasive, more patient-friendly scr...

Radiomics++: Review of Habitat Imaging Analysis for Decoding Tumor Heterogeneity.

Tumors display genomic and phenotypic heterogeneity, which holds prognostic significance and may influence therapy response. Radiographic imaging moda...

[Diagnosis and treatment of colorectal cancer in the era of artificial intelligence: review and prospect].

In recent years, artificial intelligence (AI) has achieved groundbreaking progress in the field of medicine, particularly in the diagnosis and treatme...

Prediction of 12-Week Remission in Patients With Depressive Disorder Using Reasoning-Based Large Language Models: Model Development and Validation Study.

BACKGROUND: Depressive disorder affects over 300 million people globally, with only 30% to 40% of patients achieving remission with initial antidepres...

Endocrine and metabolic determinants of cardiometabolic risk in mild autonomous cortisol secretion.

BACKGROUND: Benign adrenal tumours, found in 1-7% of adults, can be non-functioning (NFAT) or show mild autonomous cortisol secretion (MACS), i.e., bi...