Inflammatory Bowel Disease

Current Advances in Spatial Pathology of Nasal Polyps: Challenges, Opportunities for Artificial Intelligence, and Future Directions.

Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by inflammatory heterogeneity, ep...

Targeting Airway Remodeling in Severe Asthma: Is There a Window of Opportunity for Biologic Therapy Predicting Effects Using Causal Artificial Intelligence?

Airway remodeling is increasingly recognized as a major determinant of asthma progression, fixed air...

A novel inflammatory bowel disease registry powered by artificial intelligence and natural language processing.

Despite substantial recent progress in inflammatory bowel disease (IBD) therapies, there remains a l...

Epigenetic markers expand genetic risk estimation in acute myeloid leukemia.

Gene mutations and chromosome abnormalities are important components of prognostication in acute mye...

Baseline prediction of two-year prevention and remission of anxiety, depression, and eating disorders in college students receiving a digital guided self-help intervention: derivation and external validation of a machine learning algorithm across 26 population-based cohorts.

INTRODUCTION: We examined whether machine learning identified baseline variables that predicted two-...

Associations between sex steroid hormones and female malignancies: A cross-sectional analysis of NHANES data.

Sex steroid hormones, including estradiol (E2), estrone (E1), follicle-stimulating hormone (FSH), an...

Dissecting multimodal predictors of psychosis risk and remission in youth at ultra‑high risk of developing psychosis: An exploratory study.

Early identification of individuals at risk of developing psychosis enables timely intervention and ...

AI-assisted second forward-view examination of the right colon significantly improves the adenoma detection rate: a multicenter randomized controlled trial.

BACKGROUND: Adenomas in the right colon are likely to be missed during colonoscopy because of anatom...

AI-derived Histopathological Signatures Are Associated With Response to Mepolizumab in Chronic Rhinosinusitis With Nasal Polyps.

BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disease ...

Beyond ICD-10 Codes: A Multi-class Machine-Learning Approach to Identify True IBD Cases in Electronic Medical Records.

PURPOSE: The adoption of electronic medical records (EMRs) has expanded research opportunities. Inte...

Asymmetric cross-reactivity of nuclear receptors reveals an evolutionary buffer between estrogen and androgen signaling.

Nuclear receptor ligand interaction landscapes remain incompletely characterized, particularly at th...

Keeping the endoscopist in the loop: can artificial intelligence improve colonoscopy without deskilling endoscopists?

Microbiome-Driven Precision Medicine in Asthma: Roles of Targeted Therapies and Artificial Intelligence.

OBJECTIVE: To evaluate the current evidence regarding airway and gut microbiome alterations in asthm...

Radiotherapy and immunotherapy in cancer treatment: mechanisms of clinical synergy.

Synergizing radiotherapy (RT) with immune checkpoint inhibitors has emerged as a promising strategy ...

GPCR Biology-Informed Drug Discovery in Asthma.

Advances in GPCR biology and drug-discovery technology are simultaneously reshaping what can be targ...

Self-supervised monocular depth estimation for colonoscopy using normal-guided cross-attention.

PURPOSE: Reliable 3D reconstruction of colonoscopic scenes can facilitate navigation and enhance les...

VIGIL: Vision-Language Guided Multiple Instance Learning Framework for Ulcerative Colitis Histological Healing Prediction.

OBJECTIVE: Ulcerative colitis (UC) is characterized by chronic inflammation with alternating remissi...

LIMK1 and PKM as Integratively Identified Transcriptomic Signatures in Inflammatory Bowel Disease.

Inflammatory bowel disease (IBD) involves complex immunometabolic dysregulation. Mitochondria-associ...

β-Cyclodextrin-Functionalized Mycobacterium smegmatis Porin A for Steroid Discrimination and Gut Metabolite Monitoring.

Steroid metabolites like estradiol (E2) and bile acids (BAs) play pivotal roles in human metabolism ...

Rapid Resolution of Hypoxemia is Common and Associated with Lower Mortality Among Intubated Patients with Acute Hypoxemic Respiratory Failure.

ObjectiveTo evaluate the prevalence, clinical trajectory, and biologic phenotype of patients with ra...

Artificial intelligence in dermatologic pharmacokinetics: quantitative modeling, clinical translation, and optimization of precision therapeutics.

INTRODUCTION: Dermatology is rapidly transitioning from broad-spectrum therapies toward biologics, n...