Inflammatory Bowel Disease

The effectiveness of adding on or switching antiseizure medications after the first fails to control focal epilepsy: A systematic review of randomized controlled trials.

Focal epilepsy constitutes 60-70% of epilepsy, and up to half of patients do not achieve seizure freedom with their first antiseizure medication (ASM). When the first ASM fails, evidence guiding whether to switch or add-on another ASM and which ASMs to use is limited. This review synthesized evidence from randomized controlled trials (RCTs) on the comparative effectiveness of subsequent ASMs after...

AI-enabled lyophilization of advanced biologics: process intelligence, quality assessment, and formulation opportunities.

Lyophilization is a key stabilization strategy for advanced biologics, including protein therapeutics, nucleic-acid-based products, extracellular vesicles, and other highly labile biopharmaceutical systems. However, the development of lyophilized biologic products remains constrained by the intrinsic complexity of coupled heat and mass transfer, limited real-time process observability, formulation...

Epitope-Specific IgE Profiles are Predictive of Desensitization and Remission in the IMPACT Trial.

BACKGROUND: Results from the IMPACT trial suggest that initiation of peanut oral immunotherapy (pnOIT) before age 4 years can increase chances of achi...

[Sarcoidosis-associated uveitis: Current status and future prospects].

Sarcoidosis-related uveitis is the most common manifestation of ocular sarcoidosis. It can occur at any age but preferentially affects adults aged 30 ...

Real-World Evidence-Based Study on Treatment-Free Remission in Chronic Myeloid Leukemia.

BACKGROUND: Treatment-free remission (TFR) has become a treatment goal for chronic myeloid leukemia (CML). This study aimed to define precise conditio...

Rethinking aging biomarkers in HIV: from measures to meaning.

PURPOSE OF REVIEW: People with HIV (PWH) on effective antiretroviral therapy continue to experience a disproportionate burden of age-related comorbidi...

The VISION-AI Trial: protocol for a pragmatic randomized controlled non-inferiority trial comparing artificial intelligence-guided colonoscopy to pancolonic chromoendoscopy for neoplasia detection in adults with colorectal inflammatory bowel disease.

BACKGROUND: Current guidelines recommend pancolonic chromoendoscopy (pCE) over white light endoscopy (WLE) alone for colorectal neoplasia (CRN) detect...

Artificial intelligence-assisted detection and optical differentiation of colorectal lesions in Lynch syndrome surveillance (CADLY2): a multicentre, open-label, randomised controlled superiority trial.

BACKGROUND: Artificial intelligence (AI)-based computer-aided detection (CADe) systems improve adenoma detection in average-risk colorectal cancer scr...

Human-artificial intelligence adaptation in colonoscopy: beyond deskilling and upskilling.

An efficient framework for real-time colorectal polyp detection using local outlier factor-based preprocessing and YOLOv11n.

Timely and accurate detection of colorectal polyps plays an important role in the prevention and early diagnosis of colorectal cancer. Despite the adv...

Circulating multi-omic signature of disease severity and cholangiocarcinoma in primary sclerosing cholangitis.

BACKGROUND: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease often associated with inflammatory bowel disease (IBD) that ca...

Current and Novel Biomarkers for Diagnosis and Subtyping of Primary Aldosteronism.

Primary aldosteronism is a common and potentially curable cause of secondary hypertension, yet it remains substantially underdiagnosed. Current diagno...

Use of an AI Image Recognition-Based Smartphone App in Personalized Bowel Preparation Before Colonoscopy: Prospective Randomized Controlled Trial.

BACKGROUND: Sufficient bowel preparation is critical for increasing the quality of colonoscopy. However, current bowel preparation guidelines have lim...

Infection risk in rheumatoid arthritis patients treated with biologic and targeted synthetic DMARDs: prediction models and use of machine learning.

Infection risk is an important consideration during treatment decision-making in rheumatoid arthritis (RA), including at the initiation of biologics o...

Japan's contributions to hip joint preservation and reconstruction: from osteonecrosis and developmental dysplasia to precision arthroplasty.

PURPOSE: To review Japan's major contributions to hip joint preservation and reconstruction, spanning joint-preservingosteotomy, biomaterials innovati...

Toward disease-associated fecal microbiome signatures for domestic mammals.

Conserved fecal microbiome signatures of intestinal diseases across domestic mammals offer a non-invasive avenue to monitor animal health and advance ...

Disease-modifying antirheumatic drugs (DMARDs) for rheumatoid arthritis after failure of biologic or targeted synthetic therapy: a systematic review and network meta-analysis.

RATIONALE: After inadequate response to first-line biologic or targeted synthetic (b/ts) disease-modifying antirheumatic drug (DMARD) therapy in adult...

Artificial intelligence with mucosal exposure devices versus artificial intelligence alone in detection of colorectal adenomas: a systematic review and meta-analysis.

BACKGROUND AND AIMS: Both artificial intelligence (AI) and mucosal exposure devices (MEDs) have been shown to improve adenoma detection rate and reduc...

A scoping review on emerging biomarkers in inflammatory bowel disease: Towards precision medicine in diagnosis and therapeutic management.

BACKGROUND: Inflammatory Bowel Diseases (IBD) are chronic conditions presenting significant diagnostic and management challenges. Current invasive met...

Artificial Intelligence for Evidence Synthesis of Emerging Biologics to Improve Skeletal Health in Osteogenesis Imperfecta: Systematic Review and Meta-Analysis.

BACKGROUND: Osteogenesis imperfecta (OI) is a rare genetic disorder characterized by bone fragility and recurrent fractures. Emerging biologics demons...