Latest AI and machine learning research in kidney transplantation for healthcare professionals.
BACKGROUND: Sunitinib resistance remains a major clinical challenge in renal cell carcinoma, and the underlying molecular mechanisms are incompletely understood. SP5, a member of the specificity protein transcription factor family, has been implicated in tumor progression, but its role in sunitinib resistance and angiogenesis in RCC is unclear. METHODS: We integrated bulk RNA-seq datasets (GSE1721...
BACKGROUND: Suspected invasive pulmonary aspergillosis (IPA) is increasingly treated in intensive care, including in patients without classical immunosuppression. Whether current research definitions (European Organization for Research and Treatment of Cancer [EORTC]/Mycoses Study Group Education and Research Consortium (MSGERC), Invasive Fungal Diseases in Adult Patients in ICU [FUNDICU]) classif...
The Cardiovascular-Kidney-Metabolic (CKM) syndrome reframes cardiovascular, kidney, and metabolic disease as an integrated continuum, yet its manageme...
Brain cancer is one of the most challenging malignancies and a major contributor to worldwide morbidity and mortality. Glioblastoma, the most aggressi...
Prognostication in end-stage kidney disease is fundamental to person-centered care and shared decision-making. This review summarizes the current evid...
BACKGROUND: Chronic kidney disease (CKD) is projected to become one of the leading causes of premature mortality worldwide by 2050. Simultaneously, ad...
Synergizing radiotherapy (RT) with immune checkpoint inhibitors has emerged as a promising strategy for solid tumors. RT acts as a potent immunomodula...
BACKGROUND: Hyperphosphataemia is a common metabolic complication of CKD and is associated with poor health outcomes. Dietary intervention is a key st...
Thymic epithelial tumors (TETs) are rare and heterogeneous malignancies whose aggressive epithelial states and microenvironmental organization remain ...
The adrenomedullin receptor signaling pathway plays a crucial role in tumor progression, yet its comprehensive implication in hepatocellular carcinoma...
Keratinocyte carcinoma (KC) places a considerable and growing burden on healthcare systems. Given the KC population's heterogeneity, tailored clinical...
BACKGROUND: Antibody-mediated rejection (AMR) is the main driver of late kidney allograft loss. Anti-HLA donor-specific antibodies (DSA) are strongly ...
Cancer immunotherapy has transformed the treatment landscape across multiple malignancies; however, durable responses remain limited to a subset of pa...
Tumor immunotherapy has emerged as a transformative strategy for cancer treatment. However, its clinical efficacy remains limited by the immunosuppres...
Peritoneal dialysis (PD) represents one of the major modalities for home-based renal replacement therapy, offering autonomy and flexibility to patient...
Chordoma is a rare and aggressive malignant bone tumor of the axial skeleton that has historically challenged clinicians due to its complex anatomical...
Cancer is no longer viewed solely as a consequence of tumor-intrinsic genetic alterations but rather as a disease sustained by a complex and evolving ...
BACKGROUND: Mortality prediction models for patients with non-dialysis chronic kidney disease (CKD) remain limited despite their clinical importance. ...
INTRODUCTION: Infection is a common and potentially fatal complication during the treatment of hematological diseases, particularly in the context of ...