Leukemia

Characteristics of Computed Tomography Images for Patients with Acute Liver Injury Caused by Sepsis under Deep Learning Algorithm.

This study was aimed at exploring the application of image segmentation based on full convolutional neural network (FCN) in liver computed tomography (CT) image segmentation and analyzing the clinical features of acute liver injury caused by sepsis. The Sigmoid function, encoder-decoder, and weighted cross entropy loss function were introduced and optimized based on FCN. The Dice value, precision,...

Base-resolution prediction of transcription factor binding signals by a deep learning framework.

Transcription factors (TFs) play an important role in regulating gene expression, thus the identification of the sites bound by them has become a fundamental step for molecular and cellular biology. In this paper, we developed a deep learning framework leveraging existing fully convolutional neural networks (FCN) to predict TF-DNA binding signals at the base-resolution level (named as FCNsignal). ...

Identification of Pharmacophoric Fragments of DYRK1A Inhibitors Using Machine Learning Classification Models.

Dual-specific tyrosine phosphorylation regulated kinase 1 (DYRK1A) has been regarded as a potential therapeutic target of neurodegenerative diseases, ...

Automatic Segmentation of Magnetic Resonance Images of Severe Patients with Advanced Liver Cancer and the Molecular Mechanism of Emodin-Induced Apoptosis of HepG2 Cells under the Deep Learning.

To improve the accuracy of clinical diagnosis of severe patients with advanced liver cancer and enhance the effect of chemotherapy treatment, the U-Ne...

Application of High Throughput Technologies in the Development of Acute Myeloid Leukemia Therapy: Challenges and Progress.

Acute myeloid leukemia (AML) is a complex hematological malignancy characterized by extensive heterogeneity in genetics, response to therapy and long-...

Two-dimensional CNN-based distinction of human emotions from EEG channels selected by multi-objective evolutionary algorithm.

In this study we explore how different levels of emotional intensity (Arousal) and pleasantness (Valence) are reflected in electroencephalographic (EE...

Anti-Fatigue and Exercise Performance Improvement Effect of Extract in Mice.

(GT) is a native perennial plant growing across the coastline areas in Taiwan. The current study aimed to examine the efficacy of GT extract in ameli...

Optimizing a Deep Residual Neural Network with Genetic Algorithm for Acute Lymphoblastic Leukemia Classification.

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer worldwide, and it is characterized by the production of immature malignant cell...

Deep learning identifies Acute Promyelocytic Leukemia in bone marrow smears.

BACKGROUND: Acute promyelocytic leukemia (APL) is considered a hematologic emergency due to high risk of bleeding and fatal hemorrhages being a major ...

Multi-Method Diagnosis of Blood Microscopic Sample for Early Detection of Acute Lymphoblastic Leukemia Based on Deep Learning and Hybrid Techniques.

Leukemia is one of the most dangerous types of malignancies affecting the bone marrow or blood in all age groups, both in children and adults. The mos...

Experimental Research on the Antitumor Effect of Human Gastric Cancer Cells Transplanted in Nude Mice Based on Deep Learning Combined with Spleen-Invigorating Chinese Medicine.

Gastric cancer is still the fifth most common malignant tumor in the world and has the fourth highest mortality rate in the world. Gastric cancer is d...

Deep learning of quantitative ultrasound multi-parametric images at pre-treatment to predict breast cancer response to chemotherapy.

In this study, a novel deep learning-based methodology was investigated to predict breast cancer response to neo-adjuvant chemotherapy (NAC) using the...

Quantitative features to assist in the diagnostic assessment of chronic lymphocytic leukemia progression.

The use of artificial intelligence methods in the image-based diagnostic assessment of hematological diseases is a growing trend in recent years. In t...

A Transfer-Learning-Based Deep Convolutional Neural Network for Predicting Leukemia-Related Phosphorylation Sites from Protein Primary Sequences.

As one of the most important post-translational modifications (PTMs), phosphorylation refers to the binding of a phosphate group with amino acid resid...

Dynamic Bayesian networks for prediction of health status and treatment effect in patients with chronic lymphocytic leukemia.

Chronic lymphocytic leukemia (CLL) is the most common blood cancer in adults. The course of CLL and patients' response to treatment are varied. This v...

Deep learning-based AI model for signet-ring cell carcinoma diagnosis and chemotherapy response prediction in gastric cancer.

PURPOSE: We aimed to develop a noninvasive artificial intelligence (AI) model to diagnose signet-ring cell carcinoma (SRCC) of gastric cancer (GC) and...

The Effect of Robot-Mediated Virtual Reality Gaming on Upper Limb Spasticity Poststroke: A Randomized-Controlled Trial.

Stroke is a common reason for motor disability and is often associated with spasticity and poor motor function of the upper limbs involved. Spasticit...

Account of Deep Learning-Based Ultrasonic Image Feature in the Diagnosis of Severe Sepsis Complicated with Acute Kidney Injury.

This study was aimed at analyzing the diagnostic value of convolutional neural network models on account of deep learning for severe sepsis complicate...

Network biology and artificial intelligence drive the understanding of the multidrug resistance phenotype in cancer.

Globally with over 10 million deaths per year, cancer is the most transversal disease across countries, cultures, and ethnicities, affecting both deve...

WBC-AMNet: Automatic classification of WBC images using deep feature fusion network based on focalized attention mechanism.

The recognition and classification of White Blood Cell (WBC) play a remarkable role in blood-related diseases (i.e., leukemia, infections) diagnosis. ...