Transplantation

Liver Transplantation

Latest AI and machine learning research in liver transplantation for healthcare professionals.

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An improved method for predicting interactions between virus and human proteins.

The interaction of virus proteins with host proteins plays a key role in viral infection and consequent pathogenesis. Many computational methods have been proposed to predict protein-protein interactions (PPIs), but most of the computational methods are intended for PPIs within a species rather than PPIs across different species such as virus-host PPIs. We developed a method that represents key fe...

Jul 10 2016 27397631

Development and characterization of methoxy poly(ethylene oxide)--poly(ε-caprolactone) (PEO--PCL) micelles as vehicles for the solubilization and delivery of tacrolimus.

Tacrolimus is a potent immunosuppressant; however, it suffers from several problems such as poor water solubility (4-12 μg/mL), low and variable oral bioavailability in patients, and narrow therapeutic window that could not be solved by the currently available formulation (Prograf®). Moreover, Prograf® contains HCO-60 (PEGylated castor oil) as a surfactant, which is reported to cause several side...

Jul 1 2016 28344477
Ombitasvir, paritaprevir, and ritonavir plus ribavirin in adults with hepatitis C virus genotype 4 infection and cirrhosis (AGATE-I): a multicentre, phase 3, randomised open-label trial.

BACKGROUND: Hepatitis C virus (HCV) genotype 4 infection is most commonly reported in sub-Saharan Africa and the Middle East; however, prevalence is i...

Jun 16 2016 28404108
Application of a Combined Model with Autoregressive Integrated Moving Average (ARIMA) and Generalized Regression Neural Network (GRNN) in Forecasting Hepatitis Incidence in Heng County, China.

BACKGROUND: Hepatitis is a serious public health problem with increasing cases and property damage in Heng County. It is necessary to develop a model ...

Jun 3 2016 27258555
Integrative Analysis of Proteomic, Glycomic, and Metabolomic Data for Biomarker Discovery.

Studies associating changes in the levels of multiple biomolecules including proteins, glycans, glycoproteins, and metabolites with the onset of cance...

May 27 2016 27249841
Single-Port Laparoscopic Liver Resection: Largest Turkish Experience.

Single-port laparoscopic surgery has the advantage of a hidden scar and reduced abdominal wall trauma. Although single-port laparoscopic surgery is wi...

Jan 11 2016 28442836
Construction and characterization of recombinant adenovirus carrying a mouse TIGIT-GFP gene.

Recombinant adenovirus vector systems have been used extensively in protein research and gene therapy. However, the construction and characterization ...

Dec 29 2015 26782515
Reappraisal of the Immunogenicity and Safety of Three Hepatitis A Vaccines in Adolescents.

Although the overall incidence of hepatitis A in Korea has been decreasing, adolescents remain highly vulnerable to its outbreaks. This study was cond...

Dec 24 2015 26770041
The impact of paracentesis flow rate in patients with liver cirrhosis on the development of paracentesis induced circulatory dysfunction.

BACKGROUND/AIMS: Ascites is a dreadful complication of liver cirrhosis associated with short survival. Large volume paracentesis (LVP) is used to trea...

Dec 24 2015 26770925
Intrahepatic bile duct adenoma in a patient with chronic hepatitis B accompanied by elevation of alpha-fetoprotein.

A 51-year-old male patient with chronic hepatitis B was referred to our hospital due to a 1-cm liver nodule on ultrasonography. Alpha-fetoprotein (AFP...

Dec 24 2015 26770929
Evaluation of leflunomide for the treatment of BK viremia and biopsy proven BK nephropathy; a single center experience.

BACKGROUND: BK virus reactivation is a significant complication following renal transplantation that can result in graft failure. Reduction of immunos...

Dec 23 2015 27047808
Influence of vascular endothelial growth factor and alpha-fetoprotein on hepatocellular carcinoma.

We evaluated the influence of the vascular endothelial growth factor (VEGF) -C936T polymorphism on prognosis of hepatocellular carcinoma (HCC), cirrho...

Dec 21 2015 26782388
AHCC Activation and Selection of Human Lymphocytes via Genotypic and Phenotypic Changes to an Adherent Cell Type: A Possible Novel Mechanism of T Cell Activation.

Active Hexose Correlated Compound (AHCC) is a fermented mushroom extract and immune supplement that has been used to treat a wide range of health cond...

Dec 15 2015 26788109
Progressive Multifocal Leukoencephalopathy with Negative JC Virus PCR following Treatment of Follicular Lymphoma: Implications for Biologics in the Era of Targeted Cancer Therapy.

Anticancer therapy predisposes patients to infections by the immunosuppression that results from treatment. Although 85% of patients with progressive ...

Dec 15 2015 26788389
Distribution of Hepatitis C Virus Genotypes in Bahrain.

BACKGROUND: Approximately 170 million people are infected with Hepatitis C virus (HCV) worldwide, making it one of the world's major infectious diseas...

Dec 7 2015 26977163
Pulse Diagnosis Signals Analysis of Fatty Liver Disease and Cirrhosis Patients by Using Machine Learning.

OBJECTIVE: . To compare the signals of pulse diagnosis of fatty liver disease (FLD) patients and cirrhosis patients.

Nov 28 2015 27088124
Optimized combination therapies with adefovir dipivoxil (ADV) and lamivudine, telbivudine, or entecavir may be effective for chronic hepatitis B patients with a suboptimal response to ADV monotherapy.

OBJECTIVE: To identify high risk factors in chronic hepatitis B (CHB) patients for suboptimal response to adefovir dipivoxil (ADV) monotherapy, and to...

Nov 15 2015 26885037
Persistence of Anti-HBs Among Palestinian Medical Students After 18 - 22 Years of Vaccination: A Cross-Sectional Study.

BACKGROUND: Hepatitis B infection is a global public health problem affecting various sectors in the society. Vaccination is the first line measure to...

Nov 7 2015 26834785
Machine Learning for Treatment Assignment: Improving Individualized Risk Attribution.

Clinical studies model the average treatment effect (ATE), but apply this population-level effect to future individuals. Due to recent developments of...

Nov 5 2015 26958271
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