Liver Transplantation

Plant Biofactories for Vaccination: Progress in Edible Vaccine Technologies as a Sustainable Approach to Global Immunization.

Globally, the pathogen-driven enteric diseases remain a leading cause of morbidity and mortality, disproportionately affecting populations in low-income regions. While significant strides have been made in vaccine research, challenges such as high production costs, complex manufacturing processes, and inefficient distribution continue to hinder global vaccine accessibility. To overcome these chall...

Integrative profiling of senescence-associated cells and genes identifies UGT1A7 as a prognostic and therapeutic target in Lung squamous cell carcinoma.

Lung Squamous Cell Carcinoma (LUSC), a common subtype of non-small cell lung cancer, primarily occurs in elderly individuals and is closely linked to senescence-related biological processes. Meanwhile, senescence reshapes the tumor microenvironment by promoting immune suppression and angiogenesis, and its underlying mechanisms remain unclear. Here, we identified three senescence-related molecular ...

Virus infections and cancers: from mechanisms to therapeutics.

Viral infections are a major contributor to global cancer incidence and mortality. However, integrative reviews that connect viral classification, car...

Astragalus polysaccharide-based thermoresponsive hydrogel loaded with β-elemene nanoemulsion in combination with anti-PD-L1 therapy for triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is classified as an immunologically cold tumor, which markedly weakens the therapeutic efficacy of immune checkpo...

Integrative transcriptomics, machine learning, and molecular docking derive a DAM-like macrophage signature for risk stratification and therapeutic nomination in glioblastoma.

Glioblastoma presents a significant challenge for drug development due to its complex immunosuppressive microenvironment. Identifying candidate therap...

Spatial transcriptome and single-cell reveal the role of sorbitol metabolism in hepatocellular carcinoma progression and tumor microenvironment.

BACKGROUND: Metabolic reprogramming represents a hallmark feature of hepatocellular carcinoma (HCC). As a crucial branch of the polyol pathway, the bi...

Development and validation of a machine learning model to preoperatively predict very early recurrence in patients with hepatitis B virus-related hepatocellular carcinoma.

Very early recurrence (within one year) after curative hepatectomy significantly impairs long-term survival in patients with hepatitis B virus (HBV)-r...

Advances in Antiviral Drug Development Targeting Viral Proteases.

Viral proteases are critical targets in antiviral drug development due to their essential role in the viral lifecycle and high conservation across vir...

Machine Learning-Assisted SERS Quantification of Sialylated Alpha-Fetoprotein: From Single-Cell Analysis to Hepatocellular Carcinoma Risk Assessment.

Sialylated alpha-fetoprotein (sAFP) is a very potential marker for the pathogenesis exploration and clinical assessment of hepatocellular carcinoma (H...

TREM2 in glioma: Reprogramming the immune microenvironment from mechanistic understanding to clinical translation (Review).

The poor prognosis of high‑grade gliomas, such as glioblastoma, is largely driven by a notably immunosuppressive tumor microenvironment (TME), wherein...

Sex Hormone Receptors, HBV Integrations and Their Prognostic Predictive Value Among Hepatocellular Carcinoma Patients.

Hepatocellular carcinoma (HCC) related to hepatitis B virus (HBV) infection predominantly affects males, yet few studies have investigated the associa...

Multi-omics and metabolic flux modeling reveal that macrophage CYP27A1-derived 26-hydroxycholesterol drives immunosuppression and cancer malignancy.

Emerging evidence indicates that aberrant cholesterol metabolism in macrophages plays a role in tumorigenesis, however, how specific metabolites relea...

Hepatitis B virus spreading via Beddington-DeAngelis incidence function and feed-forward neural network with optimal control.

Using an appropriate mathematical model, this study aims to examine the transmission dynamics and optimal control of hepatitis B virus spreading, empl...

Leveraging multimodal cancer immunotherapy to amplify the efficacy of oncolytic viruses.

Oncolytic viruses (OVs) represent a versatile platform for cancer immunotherapy, capable of selectively infecting and lysing tumor cells while trigger...

Integrative multi-omics and machine learning reveal PLAUR as a Pan-Cancer prognostic biomarker and potential therapeutic target.

Tumor heterogeneity remains a major barrier to effective cancer therapy, driving the need for novel biomarkers and targeted strategies. A bibliometric...

Machine learning phenotypes and heterogeneous albumin effects in cirrhotic AKI: a causal inference study.

Current guidelines recommend albumin infusion as a first-line treatment for acute kidney injury (AKI) in patients with cirrhosis. However, recent larg...

A salivary protein panel for detecting malignant transformation of oral leukoplakia.

Oral leukoplakia (OLK) is the most common oral potentially malignant disorder and carries a lifetime risk of transformation to oral squamous cell carc...

Preclinical and Virtual Models of Mucosal Melanoma: Bridging Translational Gaps in a Rare and Lethal Cancer.

Mucosal melanoma (MM) is a rare and lethal subtype of melanoma, disproportionately affecting Asian populations and exhibiting distinct clinicopatholog...

Advances and prospects in cell therapy for cancer: explorations from T cells to stem cells.

The increasing global burden of cancer necessitates innovative therapeutic strategies. Cell therapy represents a major breakthrough in oncology, evolv...

Metabolic reprogramming of myeloid cells in cancer: from lactate-NAMPT axis to AI-guided therapeutics.

Myeloid cells-including macrophages, monocytes, neutrophils and dendritic cells-are metabolically plastic sentinels that shape the tumor microenvironm...