Lung Cancer

A multi-omics analysis integrating mendelian randomization, brain functional connectivity, and transcriptomics to explore risk-associated features in non-small cell lung cancer.

BACKGROUND: NSCLC remains one of the leading causes of death from cancer worldwide. Although brain metastases are indeed common and also a significant issue in some cases, what actually causes different patients with NSCLC to develop this condition or not has yet to be clarified by us so as to have a better understanding of the risk. METHODS: By integrating multi-omics data, we investigated biolog...

Thermal signatures in breast cancer: Deciphering latent biomarkers through deep learning and explainable AI.

Breast cancer, characterized by its aggressive pro-gression and high mortality rates, continues to be among the most common types of cancer. While early detection significantly improves survival outcomes, the current standard diagnostic tool, mammography, presents limitations including high costs and radiation exposure. Thermography emerges as a promising alternative, offering a non-invasive and c...

Deep Learning-Enhanced Biomarker Interpretation on Cytology Cell Blocks - Foundations and Emerging Opportunities in Spatial Pathobiology.

Cytology cell block specimens are essential diagnostic materials in patients with advanced-stage malignancy and often represent the only available sub...

Signature-aware deep learning reveals distinct driver gene programs and mutational processes in glioblastoma and colon adenocarcinoma.

The precise identification of cancer driver mutations is essential for precision oncology; however, it remains a significant challenge because of the ...

Identification of Gene Signatures Differentiating Cancer from Normal Tissues Across Histological Classifications of Gastric Adenocarcinoma via Machine Learning Methods.

Gastric adenocarcinoma is a significant global health concern. Among the myriad histologic classification methods for this cancer, the Lauren classifi...

Diagnostic Imaging Pathways in Peripheral Artery Disease: A Comparative Review of Duplex Ultrasound Through Computed Tomography Angiography.

Peripheral artery disease (PAD) is a major global health challenge, affecting more than 200 million people worldwide and an estimated 8 to 12 million ...

Artificial intelligence model for cardiovascular disease risk prediction in breast cancer patients using electronic health records and computed tomography scans.

BACKGROUND AND PURPOSE: Cardiovascular disease (CVD) is the leading cause of death globally [1] as well as the leading cause of death among cancer sur...

A machine learning model integrating circulating Temra cell transcriptional profiles to predict immunotherapy efficacy.

BACKGROUND: While immunotherapy has transformed treatment paradigms for cancer, durable response rates remain below 30%. Currently available biomarker...

Subclassification of Small Cell Lung Cancer Based on Gene Expression Signatures and Machine Learning.

Small-cell lung cancer (SCLC) is frequently subdivided into four molecular subtypes according to the activity of key transcription factors (TFs) NEURO...

Experiences of Medical Imaging and Radiation Sciences students regarding an assessment based on an artificial intelligence-generated research concept paper.

INTRODUCTION: Artificial intelligence (AI) can complete tasks that once required human cognitive effort. As a result, assessments that traditionally m...

Research on Lung Cancer Classification Based on Multidimensional Hematological Indicators and Machine Learning Models.

Accurate subtyping of lung cancer is crucial for developing personalized treatment plans and improving patient outcomes. This study established machin...

Metabolic factor-based machine learning model for mortality prediction in acute hepatitis E: Development and validation from a dual-center cohort.

BACKGROUND: Hepatitis E virus (HEV) infection remains a major cause of liver failure with high short-term mortality, yet predictive models incorporati...

Assessment of GFR Estimation Methods in Patients With Obesity.

CONTEXT: Obesity is an independent risk factor for chronic kidney disease, and accurate estimation of the glomerular filtration rate (GFR) is crucial....

Identifying a better-prognosis pancreatic cancer from its benign inflammatory mimic: a machine learning approach with contrast-enhanced ultrasound for early intervention.

PURPOSE: Hypervascular pancreatic ductal adenocarcinoma (PDAC) and mass-forming pancreatitis (MFP) represent a classic diagnostic mimicry on contrast-...

Topologically distinct 2D and 3D intratumoral heterogeneity scores for preoperatively predicting invasiveness in stage I lung adenocarcinoma: A multicenter study.

This multicenter study aims to enhance the preoperative prediction of pathological invasiveness in clinical stage I lung adenocarcinoma (LUAD) by deve...

Driver gene mutations and clinical features predict bone metastasis risk in NSCLC: a logistic regression model.

Bone metastasis affects approximately 40% of patients with non-small cell lung cancer (NSCLC), significantly impacting patient survival and prognosis....

Non-invasive prediction of Ki-67 expression in gastric cancer using AI-based dual-energy CT: a multicenter study.

OBJECTIVE: To develop and validate a machine learning model based on quantitative parameters of dual-energy CT (DECT) virtual monoenergetic images (VM...

Flow rate determination in a two-phase system using radioactive particle tracking and deep learning.

In the oil industry, accurate flow rate determination and control in pipelines are critical for ensuring operational efficiency. However, most convent...

Non-invasive screening for ovarian cancer by combining serum SERS with interpretable machine learning models.

Early identification of malignant ovarian tumors is critical for informing treatment decisions and enhancing patients' quality of life. As the third m...

Neoadjuvant Radiation is Causally Linked to Increased Operative Time and Perioperative Blood Transfusion in Pancreatic Ductal Adenocarcinoma.

INTRODUCTION: Blood transfusion in patients undergoing surgical resection for pancreatic ductal adenocarcinoma (PDAC) is associated with worse outcome...