Lung Cancer

Interpretable fusion deep learning on super-resolution MRI for perineural invasion prediction in pancreatic ductal adenocarcinoma: a multicenter study.

PURPOSE: To develop an interpretable fusion deep learning model based on super-resolution (SR) MRI for predicting preoperative perineural invasion (PNI) in pancreatic ductal adenocarcinoma (PDAC) and to evaluate its role in guiding postoperative prognostic and therapeutic decision-making. MATERIALS AND METHODS: In this multicenter retrospective study, we enrolled 714 eligible patients, allocating ...

Clinical practice, barriers to implementation, and priorities for equitable access of Stereotactic Body Radiation Therapy: An analysis of the global status by the ESTRO SBRT Focus Group.

BACKGROUND: Stereotactic Body Radiation Therapy (SBRT) has become an established treatment for several primary and metastatic malignancies; however, considerable heterogeneity remains in its definition, clinical indications, and technical delivery. METHODS: In May 2025, the SBRT Focus Group of the European Society for Radiotherapy and Oncology (ESTRO), in collaboration with International Stereotac...

Multimodality Artificial Intelligence for Involved-Site Radiation Therapy: Clinical Target Volume Delineation in High-Risk Pediatric Hodgkin Lymphoma.

PURPOSE: Clinical target volume (CTV) delineation for involved-site radiation therapy (ISRT) in Hodgkin lymphoma (HL) is time-consuming because of the...

FRET-SAM: SAM_Med2D-based automatic FRET two-hybrid analysis.

BACKGROUND AND OBJECTIVE: The fluorescence resonance energy transfer (FRET) two-hybrid assay enables quantification of the stoichiometry and binding a...

Circadian rhythm: An emerging force for colorectal cancer treatment.

The relationship between circadian rhythm disorder and the occurrence and progression of colorectal cancer (CRC) has received attention. The circadian...

Emerging nanoparticle-based therapies for pancreatic cancer: Current clinical landscape.

Pancreatic cancer, particularly ductal adenocarcinoma (PDAC) is one of the most aggressive and lethal subtypes due to late diagnosis, the absence of e...

Establishment of CT diagnostic reference levels (DRLs) in Tokyo.

OBJECTIVE: Diagnostic reference levels (DRLs) are essential for optimizing radiation dose in CT examinations. However, current DRLs may not reflect th...

Potential radiation dose reduction in computed tomography with deep learning reconstruction: a retrospective monocentric study.

PURPOSE: To evaluate whether deep learning reconstruction (DLR) can reduce the radiation dose in routine clinical computed tomography (CT) scans compa...

Attention-Guided Deep Learning of Chemical Exchange Saturation Transfer Magnetic Resonance Imaging to Differentiate Between Tumor Progression and Radiation Necrosis in Brain Metastasis.

PURPOSE: Stereotactic radiosurgery (SRS) is a standard treatment for brain metastases; however, it may lead to radiation necrosis (RN). RN can be virt...

Low-dose CBCT image reconstruction: a review.

Cone-beam computed tomography (CBCT) is a critical imaging modality in various medical fields, yet its repeated use poses radiation risks to patients....

Morphologic Evaluation of Hyperchromatic Crowded Groups Present in Cervical Thin Prep Cytology Tests as Identified by the Hologic Genius Digital Diagnostics System: A Descriptive Study.

BACKGROUND: Our descriptive study focused on morphologic characteristics of hyperchromatic crowded groups (HCGs) in ThinPrep cervical cytology tests w...

Machine learning models for predicting response to epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer brain metastases: a systematic review and meta-analysis.

BACKGROUND: Predicting clinical and radiological outcomes of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in patients with ...

Curcumin reprograms metabolic pathways and MAPK signaling to exert antidepressant effects.

BACKGROUND: Depression is a prevalent and debilitating mental disorder with limited treatment options. Curcumin, a natural compound with neuroprotecti...

3D Automated Segmentation of Bronchial Abnormalities on Ultrashort Echo Time MRI: A Quantitative MR Outcome in Cystic Fibrosis.

BACKGROUND: Cystic fibrosis (CF) monitoring relies on computed tomography (CT), but ultra-short echo time MRI (UTE-MRI) offers a radiation-free altern...

Development of a machine learning model for preoperative prediction of spread through air spaces in resectable non-small cell lung cancer: A single-center retrospective study.

Spread through air spaces (STAS) is a pathological feature associated with poor prognosis in non-small cell lung cancer (NSCLC). However, its diagnosi...

Automated quality assurance of imaging dose and protocol adherence in computed tomography radiotherapy planning using TotalSegmentator-based segmentation.

PURPOSE: Computed tomography (CT) scans are vital for radiotherapy planning, providing essential data for dose calculations. This study retrospectivel...

Three-dimensional surface scanning for registration in stereotactic neurosurgery: a cadaveric feasibility study.

OBJECTIVE: Achieving submillimetric accuracy in stereotactic neurosurgery remains critical for safely targeting deep brain structures. Current workflo...

An Explainable Deep Model for Risk Scoring and Accurate Radionecrosis Identification Following Brain Metastasis Stereotactic Radiosurgery.

PURPOSE: As survival improves for patients with brain metastases (BM), distinguishing local recurrence (LR) from radionecrosis (RN) is a growing neuro...

Artificial intelligence for TNM staging in NSCLC: a critical appraisal of segmentation utility in [1⁸F]FDG PET/CT.

PURPOSE: This study aims to investigate whether a diagnostic AI model can effectively support lesion detection and staging in non-small cell lung canc...

A Comparative, Multiobserver Analysis of Nodal Contouring Methods in Pelvic Online Cone Beam-Based Adaptive Radiation Therapy.

PURPOSE: In online cone beam computed tomography (CBCT)-based adaptive radiation therapy (ART), nodal recontouring ensures sufficient nodal coverage b...