Lupus

Reinforcement learning-based control of tumor growth under anti-angiogenic therapy.

BACKGROUND AND OBJECTIVES: In recent decades, cancer has become one of the most fatal and destructive diseases which is threatening humans life. Accordingly, different types of cancer treatment are studied with the main aim to have the best treatment with minimum side effects. Anti-angiogenic is a molecular targeted therapy which can be coupled with chemotherapy and radiotherapy. Although this met...

Hydroxytyrosol: The Phytochemical Responsible for Bioactivity of Traditionally used Olive Pits.

The fruits of L. is widely consumed as food, and olive pits are utilized in folk medicine to relieve gastric disturbances. In the present study, the possible anti-inflammatory, analgesic and antioxidant activities of aqueous extracts of black (BP) and green olive (GP) pit prepared at gastric fed state pH were evaluated Moreover, the bioactive compound, hydroxytyrosol (HT), was isolated from the ...

Synthesis of chitosan nanoparticles, chitosan-bulk, chitosan nanoparticles conjugated with glutaraldehyde with strong anti-cancer proliferative capabilities.

In recent years, natural and synthetic polymers have attracted much attention due to their great potentials in medical science. In the present study, ...

Synthesis, characterization, antimicrobial and antimetastatic activity of silver nanoparticles synthesized from Ficus ingens leaf.

Cancer incidence is still increasing due to inadequate responsive treatments. Inertness and biocompatibility of nanoparticles synthesized using plant ...

Anti-tumorigenic and Platinum-Sensitizing Effects of Apolipoprotein A1 and Apolipoprotein A1 Mimetic Peptides in Ovarian Cancer.

Apolipoprotein A1 (ApoA1) is remarkably decreased in serum and ovarian tissues of ovarian cancer patients. ApoA1 and ApoA1 mimetic peptides can seque...

Enhanced Anti-tumor of Pep-1 Modified Superparamagnetic Iron Oxide/PTX Loaded Polymer Nanoparticles.

Superparamagnetic iron-oxide nanoparticle (SPION) has gained tremendous attention for drug delivery applications due to their unique properties. In th...

Simulation program of a cytotoxic compounding robot for monoclonal antibodies and anti-infectious sterile drug preparation.

The aim of this study was to develop a specific simulation program for the validation of a cytotoxic compounding robot, KIRO® Oncology, for the prepar...

Estimating Prevalence, Demographics, and Costs of ME/CFS Using Large Scale Medical Claims Data and Machine Learning.

Techniques of data mining and machine learning were applied to a large database of medical and facility claims from commercially insured patients to d...

Fully automated detection of retinal disorders by image-based deep learning.

PURPOSE: With the aging population and the global diabetes epidemic, the prevalence of age-related macular degeneration (AMD) and diabetic macular ede...

Anti-proliferative Effect of a Novel Anti-oxidative Peptide in Hanwoo Beef on Human Colorectal Carcinoma Cells.

The present study aimed to characterise anti-oxidant peptides from water-soluble protein extracts of Hanwoo beef and evaluate their anti-proliferative...

Isolation of a Strain Producing Anti-staphylococcal Bacteriocin.

Bacteriocin is ribosomally synthesized by bacteria and inhibits closely related species. In this study we aimed at isolating lactic acid bacteria prod...

Antioxidant and Anti-Inflammatory Activity and Cytotoxicity of Ethanol Extracts from Cultivated with Mycelium.

In this study, in order to verify the use of mycelium as a new functional material, was cultivated with mycelium, and the biological activity of the...

Antiepileptic and anti-neuroinflammatory effects of red ginseng in an intrahippocampal kainic acid model of temporal lobe epilepsy demonstrated by electroencephalography.

BACKGROUND: Chronic inflammation can lower the seizure threshold and have influence on epileptogenesis. The components of red ginseng (RG) have anti-i...

BPA, BADGE and analogues: A new multi-analyte LC-ESI-MS/MS method for their determination and their in vitro (anti)estrogenic and (anti)androgenic properties.

Information on the occurrence and endocrine potencies of analogues of bisphenol A (BPA) and diglycidyl ester derivatives (BDGEs) of BPA and BPF is lim...

Multifunctional luminescent immuno-magnetic nanoparticles: toward fast, efficient, cell-friendly capture and recovery of circulating tumor cells.

Highly efficient isolation and recovery of viable circulating tumor cells (CTCs) from the blood of patients is an important precondition to address th...

Integrated machine learning pipeline for aberrant biomarker enrichment (i-mAB): characterizing clusters of differentiation within a compendium of systemic lupus erythematosus patients.

Clusters of differentiation () are cell surface biomarkers that denote key biological differences between cell types and disease state. CD-targeting t...

Biomarkers of erosive arthritis in systemic lupus erythematosus: Application of machine learning models.

OBJECTIVE: Limited evidences are available on biomarkers to recognize Systemic Lupus erythematosus (SLE) patients at risk to develop erosive arthritis...

CbpM and CbpG of Streptococcus Pneumoniae Elicit a High Protection in Mice Challenged with a Serotype 19F Pneumococcus.

Among many pneumococcal antigens, choline-binding proteins (CPBs) display a high immunogenicity in animal models. This study aims to determine the imm...

Novel electrochemical sensing platform based on a nanocomposite of PVA/PVP/RGO applied to IgG anti- Toxoplasma gondii antibodies quantitation.

This article describes the development of a new electrochemical platform composed by a polymer mixture and graphene oxide (GO). The working electrode ...

Antifungal, anti-oxidant activity and cytotoxicity of South African medicinal plants against mycotoxigenic fungi.

Fungal strains belonging to genus and are known to infect crops, resulting in threatened food security and less agricultural crop yields. The aim of...