Rheumatology

Lupus

Latest AI and machine learning research in lupus for healthcare professionals.

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Antimicrobial efficacy of Syzygium antisepticum plant extract against Staphylococcus aureus and methicillin-resistant S. aureus and its application potential with cooked chicken.

For the past decades, there has been a growing demand for natural antimicrobials in the food industry. Plant extracts have attracted strong research interests due to their wide-spectrum antimicrobial activities, but only a limited number have been investigated thoroughly. The present study aimed at identifying a novel anti-staphylococcal plant extract, to validate its activity in a food model, and...

Dec 5 2017 29407395

Modeling Anti-HIV-1 HSPC-Based Gene Therapy in Humanized Mice Previously Infected with HIV-1.

Investigations of anti-HIV-1 human hematopoietic stem/progenitor cell (HSPC)-based gene therapy have been performed by HIV-1 challenge after the engraftment of gene-modified HSPCs in humanized mouse models. However, the clinical application of gene therapy is to treat HIV-1-infected patients. Here, we developed a new method to investigate an anti-HIV-1 HSPC-based gene therapy in humanized mice pre...

Dec 1 2017 29322065
Rapid and sensitive method for simultaneous determination of first-line anti-tuberculosis drugs in human plasma by HPLC-MS/MS: Application to therapeutic drug monitoring.

First-line anti-tuberculosis drugs are playing vital roles for curbing rapid spread of tuberculosis. Multidrug therapies are commonly applied in clini...

Nov 24 2017 29559118
Preservative effect of Camellia sinensis (L.) Kuntze seed extract in soy sauce and its mutagenicity.

The purpose of this study was to investigate the applicability of green tea seed (GTS) extract as a natural preservative in food. Food preservative ab...

Nov 23 2017 29433297
An Assay Using Localized Surface Plasmon Resonance and Gold Nanorods Functionalized with Aptamers to Sense the Cytochrome-c Released from Apoptotic Cancer Cells for Anti-Cancer Drug Effect Determination.

To determine the degree of cancer cell killing after treatment with chemotherapeutic drugs, we have developed a sensitive platform using localized sur...

Nov 22 2017 30400530
Enhancement of antibody-dependent cellular cytotoxicity of cetuximab by a chimeric protein encompassing interleukin-15.

Enhancement of antibody-dependent cellular cytotoxicity (ADCC) may potentiate the antitumor efficacy of tumor-targeted monoclonal antibodies. Increasi...

Nov 13 2017 29308327
OCT-based deep learning algorithm for the evaluation of treatment indication with anti-vascular endothelial growth factor medications.

PURPOSE: Intravitreal injections with anti-vascular endothelial growth factor (anti-VEGF) medications have become the standard of care for their respe...

Nov 10 2017 29127485
Novel T-C@AgNPs mediated biocidal mechanism against biofilm associated methicillin-resistant (Bap-MRSA) 090, cytotoxicity and its molecular docking studies.

is a commonly found pathogen that can cause food-spoilage and life threatening infections. However, the potential molecular effects of natural active...

Oct 31 2017 30108735
Lupus pneumonitis presenting with high titre of anti-Ro antibody.

Lupus pneumonitis carries high mortality and is a rare manifestation of systemic lupus erythematosus (SLE). However, it is difficult to diagnose and i...

Oct 27 2017 29321925
Co-stimulation of the fc receptor and interleukin-12 receptor on human natural killer cells leads to increased expression of cd25.

Natural killer (NK) cells serve a critical role in the immune response against microbes and developing tumors. We have demonstrated that NK cells prod...

Oct 16 2017 29308301
Anti- Effects of Methanol Extracts of , and .

OBJECTIVES: The currently available agents for use against toxoplasmosis have serious limitations. Thus, the aim of the present study was to investiga...

Sep 30 2017 30087799
Pharmacokinetics, bioavailability, tissue distribution and excretion of tangeretin in rat.

Tangeretin, 4',5,6,7,8-pentamethoxyflavone, is one of the major polymethoxyflavones (PMFs) existing in citrus fruits, particularly in the peels of swe...

Sep 22 2017 29567257
Interstitial inflammation and interstitial fibrosis and tubular atrophy predict renal survival in lupus nephritis.

BACKGROUND: This study examines the effect of interstitial inflammation and interstitial fibrosis and tubular atrophy on renal survival in lupus nephr...

Aug 31 2017 29644061
Clopidogrel-Induced Insulin Autoimmune Syndrome: A Newly Recognized Cause of Hypoglycemia in a Patient Without Diabetes.

Insulin autoimmune syndrome (IAS), defined as hyperinsulinemic hypoglycemia with high titers of anti-insulin antibodies, is frequently reported in Jap...

Aug 28 2017 29264578
Word2Vec inversion and traditional text classifiers for phenotyping lupus.

BACKGROUND: Identifying patients with certain clinical criteria based on manual chart review of doctors' notes is a daunting task given the massive am...

Aug 22 2017 28830409
Effects of Oleo Gum Resin of L. on Senescence in Human Dermal Fibroblasts: - Asafoetida reverses senescence in fibroblasts.

OBJECTIVES: Based on data from Chinese and Indian traditional herbal medicines, gum resin of (sometimes referred to asafetida or asafoetida) has seve...

Jul 30 2017 30087798
Antiphospholipid Antibodies and Heart Valve Disease in Systemic Lupus Erythematosus.

Evaluation of antiphospholipid antibodies (aPL) and correlation with heart valve abnormalities among patients with systemic lupus erythematosus (SLE)....

Jul 20 2017 29549933
Virtual-screening workflow tutorials and prospective results from the Teach-Discover-Treat competition 2014 against malaria.

The first challenge in the 2014 competition launched by the Teach-Discover-Treat (TDT) initiative asked for the development of a tutorial for ligand-b...

Jul 17 2017 28928948
Evaluating the impact of vitreomacular adhesion on anti-VEGF therapy for retinal vein occlusion using machine learning.

Vitreomacular adhesion (VMA) represents a prognostic biomarker in the management of exudative macular disease using anti-vascular endothelial growth f...

Jun 7 2017 28592811
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