Menopause

The knowledge distillation-assisted multimodal model for osteoporosis screening.

BACKGROUND AND OBJECTIVE: Osteoporosis is characterized by reduced bone mass and deterioration of bone structure, yet screening rates prior to fractures remain low. Given its high prevalence and severe consequences, developing an effective osteoporosis screening model is highly significant. However, constructing these screening models presents two main challenges. First, selecting representative s...

A labeled dataset for osteoporosis screening based on electromagnetic attenuation.

Resting-State Functional MRI Reveals Altered Seed-Based Connectivity in Diabetic Osteoporosis Patients.

BACKGROUND: Diabetic osteoporosis (DOP) can cause abnormal brain neural activity, but its mechanism is still unclear. This study aims to further explo...

Enhancing ERα-targeted compound efficacy in breast cancer threapy with ExplainableAI and GeneticAlgorithm.

Breast cancer remains a major cause of mortality among women globally, driving the need for advanced therapeutic solutions. This study presents a nove...

Oxidative balance score and menopausal status: insights from epidemiological analysis and machine learning models.

BACKGROUND: Unhealthy lifestyle habits, such as smoking, can impact oxidative stress. During oxidative stress, unnaturalized free radicals can damage ...

Uncemented hip arthroplasty and denosumab: increased postoperative dipeptide concentrations and identification of potential new bone turnover biomarkers.

Denosumab is a potent antagonist of RANKL and is widely used to treat severe postmenopausal osteoporosis. Using high-resolution mass spectrometry (HRM...

Non-orthogonal kV imaging guided patient position verification in non-coplanar radiation therapy with dataset-free implicit neural representation.

BACKGROUND: Cone-beam CT (CBCT) is crucial for patient alignment and target verification in radiation therapy (RT). However, for non-coplanar beams, p...

Deciphering the Immunomodulatory Function of GSN Inflammatory Cancer-Associated Fibroblasts in Renal Cell Carcinoma Immunotherapy: Insights From Pan-Cancer Single-Cell Landscape and Spatial Transcriptomics Analysis.

The heterogeneity of cancer-associated fibroblasts (CAFs) could affect the response to immune checkpoint inhibitor (ICI) therapy. However, limited stu...

In utero heat stress compromises whole-body growth and mammary development from postweaning through puberty.

Late-gestation in utero heat stress derails organ development and growth, leading to reduced first-lactation milk yield. Yet, carry-over effects of in...

Arylacetamides exhibit antiproliferative effects on non-transformed mammalian and vegetal cells and toxicity on crustaceans and fish embryos.

Non-clinical steps for development, validation and biosafety of new medicines and products comprises studies on cells, proteins, and animals. Herein, ...

Branding a New Technological Outlook for Future Orthopaedics.

Orthopedics is undergoing a transformative shift driven by personalized medical technologies that enhance precision, efficiency, and patient outcomes....

The Role of Computed Tomography and Artificial Intelligence in Evaluating the Comorbidities of Chronic Obstructive Pulmonary Disease: A One-Stop CT Scanning for Lung Cancer Screening.

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Comorbidities in patients with COPD significantly ...

Replacing non-biomedical concepts improves embedding of biomedical concepts.

Embeddings are semantically meaningful representations of words in a vector space, commonly used to enhance downstream machine learning applications. ...

Entity replacement strategy for temporal knowledge graph query relaxation.

The temporal knowledge graph (TKG) query enables the retrieval of candidate answer lists by addressing questions that involve temporal constraints, re...

Deep Learning-enhanced Opportunistic Osteoporosis Screening in Ultralow-Voltage (80 kV) Chest CT: A Preliminary Study.

RATIONALE AND OBJECTIVES: To explore the feasibility of deep learning (DL)-enhanced, fully automated bone mineral density (BMD) measurement using the ...

Application of multivalent aptamers in tumor diagnosis, analysis and therapy (Review).

Cancer remains one of the leading causes of mortality worldwide, making early diagnosis and precise treatment crucial for enhancing patient survival r...

Artificial intelligence-based modeling of biogas production in a combined microbial electrolysis cell-anaerobic digestion system using artificial neural networks and adaptive neuro-fuzzy inference system.

Accurate prediction of biogas production is essential for optimizing process performance, enhancing system stability, and enabling efficient resource ...

From Nuclear Receptors to GPCRs: a Deep Transfer Learning Approach for Enhanced Environmental Estrogen Recognition.

Environmental estrogens (EEs), as typical endocrine-disrupting chemicals (EDCs), can bind to classic estrogen receptors (ERs) to induce genomic effect...

Using artificial intelligence-based software for an unbiased discrimination of immune cell subtypes in the fracture hematoma and bone marrow of non-osteoporotic and osteoporotic mice.

It is well established that the early inflammatory response following fracture is essential for initiating subsequent bone regeneration. An imbalance ...

Therapeutic potential of enzymes, neurosteroids, and synthetic steroids in neurodegenerative disorders: A critical review.

Neurodegenerative disorders present a significant challenge to healthcare systems, mainly due to the limited availability of effective treatment optio...