Menopause

Effects of targeting highly expressed in cancer protein 1 (Hec1) inhibitor INH 1 in breast cancer cell lines In Vitro.

In the present study, the in vitro antiproliferative effect of targeting highly expressed cancer protein 1 (Hec1) inhibitor INH1 was investigated in estrogen receptor-positive MCF-7 cell line originating from an in situ carcinoma and triple negative MDA-MB-231 cell line originating from metastatic carcinoma. Cell viability, xCELLigence RTCA DP instrument CI values, MI, BrdU proliferation assay, an...

Select or adjust? How information from early treatment stages boosts the prediction of non-response in internet-based depression treatment.

BACKGROUND: Internet-based interventions produce comparable effectiveness rates as face-to-face therapy in treating depression. Still, more than half of patients do not respond to treatment. Machine learning (ML) methods could help to overcome these low response rates by predicting therapy outcomes on an individual level and tailoring treatment accordingly. Few studies implemented ML algorithms in...

Asprosin is a Reliable Predictor of Osteoporosis in Type 2 Diabetic Postmenopausal Women: A Case-Control Study.

The study evaluates Asprosin's value in diabetic postmenopausal women, examining its reliability as a predictor for osteoporosis (OP) in the second ty...

Deep Learning-Guided Dosimetry for Mitigating Local Failure of Patients With Non-Small Cell Lung Cancer Receiving Stereotactic Body Radiation Therapy.

PURPOSE: Non-small cell lung cancer (NSCLC) stereotactic body radiation therapy with 50 Gy/5 fractions is sometimes considered controversial, as the n...

Deep learning-enabled breast cancer endocrine response determination from H&E staining based on ESR1 signaling activity.

Estrogen receptor (ER) positivity by immunohistochemistry has long been a main selection criterium for breast cancer patients to be treated with endoc...

Optimization of operational parameters using RSM, ANN, and SVM in membrane integrated with rotating biological contactor.

Membrane fouling is a critical bottleneck to the widespread adoption of membrane separation processes. It diminishes the membrane permeability and res...

An in-depth survey on Deep Learning-based Motor Imagery Electroencephalogram (EEG) classification.

Electroencephalogram (EEG)-based Brain-Computer Interfaces (BCIs) build a communication path between human brain and external devices. Among EEG-based...

DeepHLAPred: a deep learning-based method for non-classical HLA binder prediction.

Human leukocyte antigen (HLA) is closely involved in regulating the human immune system. Despite great advance in detecting classical HLA Class I bind...

Hot topics in allergen immunotherapy, 2023: Current status and future perspective.

The importance of allergen immunotherapy (AIT) is multifaceted, encompassing both clinical and quality-of-life improvements and cost-effectiveness in ...

Large-scale pancreatic cancer detection via non-contrast CT and deep learning.

Pancreatic ductal adenocarcinoma (PDAC), the most deadly solid malignancy, is typically detected late and at an inoperable stage. Early or incidental ...

iHBPs-VWDC: variable-length window-based dynamic connectivity approach for identifying hormone-binding proteins.

Hormone-binding proteins (HBPs) are soluble carrier proteins that play a vital role in the growth and development of living organisms. Identifying HBP...

Efficacy of an automated technology at detecting early postpartum estrus events: Can we detect resumption of cyclicity?

The objective of this observational study was to evaluate the efficacy of a neck-mounted automated activity monitor (AAM) at detecting early postpartu...

Fusion of electronic health records and radiographic images for a multimodal deep learning prediction model of atypical femur fractures.

Atypical femur fractures (AFF) represent a very rare type of fracture that can be difficult to discriminate radiologically from normal femur fractures...

A machine learning approach to identify important variables for distinguishing between fallers and non-fallers in older women.

Falls are a significant ongoing public health concern for older adults. At present, few studies have concurrently explored the influence of multiple m...

Unveiling Osteoporosis Through Radiomics Analysis of Hip CT Imaging.

RATIONALE AND OBJECTIVES: This study aims to investigate the use of radiomics analysis of hip CT imaging to unveil osteoporosis.

Comparative Analysis of Audio Processing Techniques on Doppler Radar Signature of Human Walking Motion Using CNN Models.

Artificial intelligence (AI) radar technology offers several advantages over other technologies, including low cost, privacy assurance, high accuracy,...

Automated vertebral bone mineral density measurement with phantomless internal calibration in chest LDCT scans using deep learning.

OBJECTIVE: To develop and evaluate a fully automated method based on deep learning and phantomless internal calibration for bone mineral density (BMD)...

Cholesterol Levels, Hormone Replacement Therapy, and Incident Dementia among Older Adult Women.

Previous studies revealed that hormone replacement therapy (HRT) probably has a protective effect for preventing dementia in post-menopausal women. Ho...

A Concentric Tube Steerable Drilling Robot for Minimally Invasive Spinal Fixation of Osteoporotic Vertebrae.

Spinal fixation with rigid pedicle screws have shown to be an effective treatment for many patients. However, this surgical option has been proved to ...

A 48-Year-Old Man With a Hip Fracture and Skin Rash: A Case Report.

BACKGROUND/OBJECTIVE: Patients with systemic mastocytosis are at high risk of developing osteoporosis and fractures. Herein, we report a case of hip f...