Endocrinology

Menopause

Latest AI and machine learning research in menopause for healthcare professionals.

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Estimating bone marrow adiposity from head MRI and identifying its genetic architecture

Bone marrow adiposity changes radically through the lifespan, but this phenomenon is poorly characterised and understood in humans. Large datasets of magnetic resonance imaging (MRI) scans of the head have been collected to study the human brain, but also contain unexploited information about other organs. We developed an artificial neural network that localises calvarial bone marrow in T1-weighte...

Using Deep Learning Models of Gene Regulation to Guide Drug Prioritization

Drug repurposing offers a cost-effective strategy to accelerate therapeutic discovery, but most computational approaches fail to model noncoding genetic variation. Because over 90% of genome-wide association study (GWAS) risk variants reside in noncoding regions, linking regulatory variation to therapeutic hypotheses remains a major challenge. Here, we developed an integrative deep learning framew...

Predicting Response to Neoadjuvant Chemotherapy in Ovarian Cancer from CT Baseline Using Multi-Loss Deep Learning

Ovarian cancer is the most lethal gynecologic malignancy: around 60% of patients are diagnosed at an advanced stage, with an associated 5-year surviva...

May 14 2026 2605.14991v1
Characterization of menopause onset and associated disease risks using large-scale electronic health records

Menopause affects over one billion women worldwide, yet remains poorly characterized at scale. We apply an ICD-10-based phenotyping algorithm to elect...

Muown: Row-Norm Control for Muon Optimization

Muon has emerged as a strong competitor to AdamW for language model pre-training, yet its behavior at scale is sensitive to weight decay. Recent work ...

May 11 2026 2605.10797v1
Machine Learning-Driven Multiplexed Biomarker Detection with Polymer-Enhanced Electrochemical Sensors

Biomarkers in sweat and saliva offer a promising avenue for non-invasive health monitoring. Electrochemical sensors have the potential to measure such...

Extracting adverse event nature, severity, timelines and resulting interventions from clinical notes of patients receiving CAR-T therapy using large language models.

Chimeric Antigen Receptor T-cell (CAR-T) therapy, where genetically engineered patient T cells target tumor antigens, has transformed care for hematol...

Identity-Decoupled Anonymization for Visual Evidence in Multi-modal Retrieval-Augmented Generation

Multi-modal retrieval-augmented generation (MRAG) systems retrieve visual evidence from large image corpora to ground the responses of large multi-mod...

Apr 26 2026 2604.23584v1
AI-Based Clinical Decision Support Systems for Secondary Caries on Bitewings: A Multi-Algorithm Comparison

Background: Radiographic detection of caries lesions adjacent to restorations is challenging due to limitations of two-dimensional imaging and difficu...

Reliability Auditing for Downstream LLM tasks in Psychiatry: LLM-Generated Hospitalization Risk Scores

Large language models (LLMs) are increasingly utilized in clinical reasoning and risk assessment. However, their interpretive reliability in critical ...

Apr 23 2026 2604.22063v1
Rethinking Where to Edit: Task-Aware Localization for Instruction-Based Image Editing

Instruction-based image editing (IIE) aims to modify images according to textual instructions while preserving irrelevant content. Despite recent adva...

Apr 22 2026 2604.20258v1
Opportunistic Bone-Loss Screening from Routine Knee Radiographs Using a Multi-Task Deep Learning Framework with Sensitivity-Constrained Threshold Optimization

Background: Osteoporosis and osteopenia are often undiagnosed until fragility fractures occur. Dual-energy X-ray absorptiometry (DXA) is the reference...

Apr 22 2026 2604.20268v1
CLIP-Guided Data Augmentation for Night-Time Image Dehazing

Nighttime image dehazing faces a more complex degradation pattern than its daytime counterpart, as haze scattering couples with low illumination, non-...

Apr 7 2026 2604.05500v1
Universal computational thermal imaging overcoming the ghosting effect

Thermal imaging is crucial for night vision but fundamentally hampered by the ghosting effect, a loss of detailed texture in cluttered photon streams....

Apr 2 2026 2604.01542v1
A deep learning pipeline for PAM50 subtype classification using histopathology images and multi-objective patch selection

Breast cancer is a highly heterogeneous disease with diverse molecular profiles. The PAM50 gene signature is widely recognized as a standard for class...

Apr 2 2026 2604.01798v1
AI-driven selection of patients with non-valvular atrial fibrillation for oral anticoagulation therapy: a multi-cohort validation and impact evaluation study

Background: Current risk assessment tools for guiding direct oral anticoagulant (DOAC) therapy for patients with atrial fibrillation (AF) based on cli...

Illumination-Aware Contactless Fingerprint Spoof Detection via Paired Flash-Non-Flash Imaging

Contactless fingerprint recognition enables hygienic and convenient biometric authentication but poses new challenges for spoof detection due to the a...

Mar 18 2026 2603.17679v1
A DNA foundation model predicts osteoporosis risk genes without proximity bias

Targets supported by human genetic associations are more than twice as likely to progress from clinical development to approval. Genome-wide associati...

Transformer-Based Multi-Region Segmentation and Radiomic Analysis of HR-pQCT Imaging for Osteoporosis Classification

Osteoporosis is a skeletal disease typically diagnosed using dual-energy X-ray absorptiometry (DXA), which quantifies areal bone mineral density but o...

Mar 10 2026 2603.09137v2
Transformer-Based Multi-Region Segmentation and Radiomic Analysis of HR-pQCT Imaging

Osteoporosis is a skeletal disease typically diagnosed using dual-energy X-ray absorptiometry (DXA), which quantifies areal bone mineral density but o...

Mar 10 2026 2603.09137v1
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