Latest AI and machine learning research in menopause for healthcare professionals.
Clonal haematopoiesis (CH) becomes ubiquitous as humans age. The role of somatic driver mutations in its development has been studied widely, but little is known about CH without identified genetic drivers, also known as "CH with unknown drivers" (CH-UD). A fundamental unresolved question is whether CH-UD is driven by undiscovered somatic genetic drivers or by other cell-heritable traits. Here, to...
Drug repurposing offers a cost-effective strategy to accelerate therapeutic discovery, but most computational approaches fail to model noncoding genetic variation. Because over 90% of genome-wide association study (GWAS) risk variants reside in noncoding regions, linking regulatory variation to therapeutic hypotheses remains a major challenge. Here, we developed an integrative deep learning framew...
Ovarian cancer is the most lethal gynecologic malignancy: around 60% of patients are diagnosed at an advanced stage, with an associated 5-year surviva...
Menopause affects over one billion women worldwide, yet remains poorly characterized at scale. We apply an ICD-10-based phenotyping algorithm to elect...
Muon has emerged as a strong competitor to AdamW for language model pre-training, yet its behavior at scale is sensitive to weight decay. Recent work ...
Biomarkers in sweat and saliva offer a promising avenue for non-invasive health monitoring. Electrochemical sensors have the potential to measure such...
Chimeric Antigen Receptor T-cell (CAR-T) therapy, where genetically engineered patient T cells target tumor antigens, has transformed care for hematol...
Adverse drug effects remain a major barrier to safe and effective cancer therapy, underscoring the need for tools that predict treatment-related toxic...
Multi-modal retrieval-augmented generation (MRAG) systems retrieve visual evidence from large image corpora to ground the responses of large multi-mod...
Background: Radiographic detection of caries lesions adjacent to restorations is challenging due to limitations of two-dimensional imaging and difficu...
Large language models (LLMs) are increasingly utilized in clinical reasoning and risk assessment. However, their interpretive reliability in critical ...
Instruction-based image editing (IIE) aims to modify images according to textual instructions while preserving irrelevant content. Despite recent adva...
Background: Osteoporosis and osteopenia are often undiagnosed until fragility fractures occur. Dual-energy X-ray absorptiometry (DXA) is the reference...
Nighttime image dehazing faces a more complex degradation pattern than its daytime counterpart, as haze scattering couples with low illumination, non-...
Thermal imaging is crucial for night vision but fundamentally hampered by the ghosting effect, a loss of detailed texture in cluttered photon streams....
Breast cancer is a highly heterogeneous disease with diverse molecular profiles. The PAM50 gene signature is widely recognized as a standard for class...
Background: Current risk assessment tools for guiding direct oral anticoagulant (DOAC) therapy for patients with atrial fibrillation (AF) based on cli...
Contactless fingerprint recognition enables hygienic and convenient biometric authentication but poses new challenges for spoof detection due to the a...
Targets supported by human genetic associations are more than twice as likely to progress from clinical development to approval. Genome-wide associati...
Identifying predictive biomarkers of immunotherapeutic response in melanoma remains an outstanding challenge. Existing transcriptomic and proteomic pr...