Hematology

Multiple Myeloma

Latest AI and machine learning research in multiple myeloma for healthcare professionals.

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BAF complexes maintain accessibility at stimulus-responsive chromatin and are required for transcriptional stimulus responses

Background Gene expression changes in response to developmental and environmental cues rely on cis-regulatory sequence elements (cREs). BRG1/BRM-Associated Factors (BAF) chromatin remodeling complexes maintain chromatin accessibility at many cREs, enabling binding by transcription factors (TFs). However, cREs exhibit a broad range of sensitivity to loss of BAF function, and the basis of this varia...

Unveiling the role of oxidative stress in ANCA-associated glomerulonephritis through integrated machine learning and bioinformatics analyses.

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease often leading to rapidly progressive glomerulonephritis. Oxidative stress plays a critical role in the development and progression of ANCA-associated glomerulonephritis (AAGN), but the underlying mechanisms remain poorly understood. Targeting genes related to oxidative stress may provide novel ...

Dec 1 2025 40369957
Revisiting the role of steroidal therapeutics in the 21st century: an update on FDA approved steroidal drugs (2000-2024).

Steroids are biologically active polycyclic compounds that have garnered significant scientific attention due to their distinct physiochemical propert...

May 8 2025 40352672
Gamma/hadron separation in the TAIGA experiment with neural network methods

In this work, the ability of rare VHE gamma ray selection with neural network methods is investigated in the case when cosmic radiation flux strongl...

RPEGENE-Net: A Multi-Resolution Deep Learning Framework for Predicting Gene Expression from Microscopy Images of Retinal Pigment Epithelium (RPE) Cells

To develop a deep learning framework, RPEGENE-Net, capable of predicting gene expression profiles of retinal pigment epithelium (RPE) cells using live...

Screening of Oyster Peptides for Anti-Muscle Atrophy Based on Machine Learning and Computer Simulation: Guided by Antioxidant Pathways

Muscle atrophy poses a serious threat to human health, with its primary pathogenic mechanisms closely linked to oxidative stress. This study focuses o...

Quantitative analysis of the dexamethasone side effect on human-derived young and aged skeletal muscle by myotube and nuclei segmentation using deep learning.

MOTIVATION: Skeletal muscle cells (skMCs) combine together to create long, multi-nucleated structures called myotubes. By studying the size, length, a...

Dec 26 2024 39752317
PBAC: A pathway-based attention convolution neural network for predicting clinical drug treatment responses.

Precise and personalized drug application is crucial in the clinical treatment of complex diseases. Although neural networks offer a new approach to i...

May 1 2024 38683133
Utilizing dehydroepiandrosterone sulfate and its ratio for detecting mild autonomous cortisol excess in patients with adrenal incidentaloma.

Subclinical Cushing syndrome is a condition of mild autonomous cortisol excess (MACE) that lacks typical features of Cushing syndrome but is associate...

Oct 1 2023 38313163
Stability and compatibility of methotrexate and dexamethasone in 0.9% sodium chloride for intrathecal injection.

The stability of a mixture of methotrexate and dexamethasone sodium phosphate in 0.9% sodium chloride for intrathecal (IT) injection was assessed. To ...

Nov 1 2020 33867319
Hydro-Ethanolic Extract of Ameliorates Total and Differential WBC, Lung Pathology and Oxidative Biomarkers in Asthmatic Rats.

The effects of ( ; PO) on total and differential WBC count, and oxidant/antioxidant biomarkers in bronchoalveolar lavage fluid (BALF) as well as on l...

Jan 1 2019 32184860
Dexamethasone Versus Ketamine in the Interscalene Block in Patients Undergoing Arthroscopic Shoulder Surgery: A Randomized Double-Blinded Study.

OBJECTIVE: Arthroscopic shoulder surgery (ASS) is often followed by severe pain. Interscalene brachial plexus block (ISB) was used to relieve such pai...

Dec 1 2018 30922018
Comparative Evaluation of Ropivacaine and Ropivacaine with Dexamethasone in Transverse Abdominis Plane Block for Lower Abdominal Surgeries: A Prospective, Randomized, Double-Blinded Study.

CONTEXT: Dexamethasone as an adjunct to ropivacaine has shown promising results in prolonging the duration of analgesia in transverse abdominis plane ...

Jan 1 2018 30662134
Anti-inflammatory Effect of Amitriptyline on Ulcerative Colitis in Normal and Reserpine-Induced Depressed Rats.

Depressive disorders are more common among persons with chronic diseases such as inflammatory bowel disease and anti-inflammatory effect of some antid...

Jan 1 2016 28228811
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